Could a cholesterol drug boost immunotherapy in lung cancer?

NCT ID NCT05144529

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether adding evolocumab (a cholesterol-lowering drug) to standard immunotherapy (nivolumab and ipilimumab) is safe and helps the immune system fight advanced non-small cell lung cancer. It included 19 people with newly diagnosed metastatic lung cancer who had not received prior treatment. The study was stopped early, so results are limited.

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Conditions

The condition(s) this trial relates to.

lung cancer metastatic malignant neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Duke Univ. Medical Center

    Durham, North Carolina, 27710, United States