Can a scope in the stomach measure hidden liver pressure?
NCT ID NCT07782554
First seen Aug 24, 2026 · Last updated Aug 25, 2026 · Updated 1 time
Summary
This study looks at whether a new endoscopic ultrasound technique can directly measure the pressure in the portal vein, which carries blood to the liver. It focuses on people with cirrhosis who also have a blockage in the portal vein, a condition where standard pressure measurements may be inaccurate. Researchers will compare the new method's readings with the traditional approach and see how they relate to patient symptoms and outcomes. The goal is to see if this technique could provide a more reliable way to assess and manage this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Endoscopic ultrasound-guided portal pressure gradient measurement (EUS-PPG)
- What this could lead to
- If EUS-PPG proves reliable, it could offer a more accurate way to assess portal hypertension in patients where standard methods fall short, potentially guiding better treatment decisions.
- What could go wrong
- This is a small, retrospective study, so results may not apply broadly. The procedure is invasive and carries risks like bleeding or infection, and the correlation with standard measures may not be strong enough to change practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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59 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This study included patients with liver cirrhosis complicated by prehepatic portal hypertension due to portal venous obstruction. All patients had esophagogastric varices and underwent abdominal computed tomography, ultrasound elastography, hepatic venous pressure gradient measurement, and endoscopic ultrasound-guided portal pressure gradient measurement. The study evaluated the relationship between portal pressure measurements and clinical characteristics, including liver disease etiology, liver function grade, gastrointestinal bleeding, and hepatic encephalopathy.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Age ≥18 years; Confirmed diagnosis of cirrhosis complicated by portal venous obstructionbased on clinical, laboratory, and imaging findings; Written informed consent; Exclusion Criteria: Severe coagulopathy, defined as an International Normalized Ratio (INR) \>1.5; Severe thrombocytopenia, defined as a platelet count \<30 × 10\^9/L; Severe systemic comorbidities, including active sepsis, decompensated heart failure, or severe chronic obstructive pulmonary disease; Psychiatric or cognitive disorders that preclude cooperation with study procedures; Refusal to undergo hepatic venous pressure gradient (HVPG) or endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurement;
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China