Major trial aims to cure kids with lymphoma while reducing radiation

NCT ID NCT02684708

First seen Apr 21, 2026 · Last updated May 08, 2026 · Updated 2 times

Summary

This large international study tested whether we can safely use less radiation and adjust chemotherapy for children and teens with classical Hodgkin lymphoma without lowering cure rates. Over 2,900 newly diagnosed patients under 18 (and up to 25 in some countries) took part. The goal was to maintain high cure rates while reducing long-term side effects from treatment.

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Contacts and locations

Locations

  • CHUV - Centre Hospitalier Universitaire Vaudois = LS, Départment femme - meré - enfant, Service de pédiatrie, Unité d'hématologie-oncologie pédiatrique

    Lausanne, 1011, Switzerland

  • Clinic of Pediatric Oncology University Children's Hospital

    Bratislava, 83340, Slovakia

  • Department of Medical Oncology Oslo University Hospital

    Oslo, 0424, Norway

  • Department of Pediatric Hematology/Oncology (5054) The Child and Youth Clinic, University Hospital of Copenhagen

    Copenhagen, 2100, Denmark

  • Dpt. of Pediatric Hematology and Oncology, Faculty Hospital Motol

    Prague, 15006, Czechia

  • Head of Department of Pediatric Oncology and Hematology, Polish-American Pediatric Institute, Jagiellonian University Medical Faculty

    Krakow, 30-663, Poland

  • Justus Liebig University of Giessen

    Giessen, 35392, Germany

  • Our Lady's Children's Hospital, Crumlin

    Dublin, 12, Ireland

  • Paediatric haemato-oncology, University Hospitals of Leuven

    Leuven, 3000, Belgium

  • Pediatric Hematology & Oncology Children´s University Hospital

    Uppsala, 75185, Sweden

  • Pediatric Radiotherapy and Youth Area Unit C.R.O. - Centro di Riferimento Oncologico IRCCS

    Aviano, 33081, Italy

  • Princess Máxima Center for pediatric oncology

    Utrecht, 3508, Netherlands

  • Royal Children's Hospital and Monash Medical Centre Royal Children's Hospital

    Victoria Park, 3052, Australia

  • Sección de Onco-Hematología Pediátrica Hospital Universitario Virgen Macarena y Virgen del Rocío

    Seville, 41071, Spain

  • Service d'Oncohématologie, Hopital d'Ènfants Armand Trousseau

    Paris, 75571, France

  • St. Anna Kinderspital

    Vienna, 1090, Austria

  • Starship Blood and Cancer Centre, Starship Children's Hospital

    Auckland, 1142, New Zealand

  • Tel Aviv University Schneider Children's Medical Center of Israel The Rina Zaizov Pediatric Hematology Oncology Division

    Petah Tikva, 49202, Israel

  • University College London Hospitals

    London, NW1 2PG, United Kingdom

Conditions

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