New drug trial aims to tame debilitating sickle cell pain crises

NCT ID NCT06612268

Recruiting now Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether a new oral drug called etavopivat can reduce the number of painful blockages in blood vessels (called vaso-occlusive crises) in people aged 12 and older with sickle cell disease. Participants will be randomly assigned to receive either the study drug or a placebo for about two years. The study will also measure if the drug helps reduce organ damage, improve energy levels, and increase exercise tolerance.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

"AHEPA" University General Hospital of Thessaloniki
RECRUITING

Thessaloniki, 546 36, Greece
"AHEPA" University General Hospital of Thessaloniki
NOT_YET_RECRUITING

Thessaloniki, 546 36, Greece
"Laiko" General Hospital of Athens
RECRUITING

Athens, 115 26, Greece
A.O.U. Università Studi della Campania "Luigi Vanvitelli"
NOT_YET_RECRUITING

Naples, 80138, Italy
AP-HP-HOPITAL NECKER_Service d'hématologie
NOT_YET_RECRUITING

Paris, 75015, France
ARNAS Garibaldi Catania - Presidio Ospedaliero Garibaldi-Centro
RECRUITING

Catania, 95123, Italy
ASST Civili di Brescia
RECRUITING

Brescia, 25123, Italy
Acıbadem Adana Hastanesi-Hematoloji
RECRUITING

Adana, 01130, Turkey (Türkiye)
Addenbrooke's Hospital - Haemophilia and Thrombophilia
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Agogo Presbyterian Hospital, Ghana
COMPLETED

Agogo, 0000, Ghana
Ahero Clinical Trials Unit
NOT_YET_RECRUITING

Kisumu, 40101, Kenya
All India Institute of Medical Sciences (AIIMS), Raipur
RECRUITING

Raipur, Chhattisgarh, 492099, India
All India Institute of Medical Sciences_New Dehli
RECRUITING

New Delhi, 110029, India
American University of Beirut Medical Centre
NOT_YET_RECRUITING

Hamra, 11-0236, Lebanon
Amsterdam UMC Lokatie VUMC
RECRUITING

Amsterdam, 1081 HV, Netherlands
Ap-Hp-Hopital Avicenne
NOT_YET_RECRUITING

Bobigny, 93000, France
Ap-Hp-Hopital Henri Mondor
RECRUITING

Créteil, 94000, France
Ap-Hp-Hopital Robert Debre
RECRUITING

Paris, 75019, France
Arihant Multispeciality Hospital
RECRUITING

Nagpur, Maharashtra, 440026, India
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202, United States
Atrium Health-Wake Forest Bapt
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Azienda Ospedale Universita Padova
RECRUITING

Padua, 35128, Italy
Azienda Ospedaliera Ospedali Riuniti Villa Sofia - Cervello
RECRUITING

Palermo, 90146, Italy
Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma - Centro Ricerche Cliniche Di Verona S.r.l.
RECRUITING

Verona, Veneto, 37134, Italy
Azienda Ospedaliera Universitaria San Luigi Gonzaga
NOT_YET_RECRUITING

Orbassano, Torino, 10043, Italy
Azienda Ospedaliera Universitaria San Luigi Gonzaga - S.C.D.O. Microcitemie e malattie rare ematologiche
RECRUITING

Orbassano, Torino, 10043, Italy
Azienda Ospedaliero Universitaria Di Modena - UOC Pediatria ad indirizzo Oncoematologico
NOT_YET_RECRUITING

Modena, 41100, Italy
BC Children's Hospital
RECRUITING

Vancouver, British Columbia, V6H 3V4, Canada
Başkent Üniversitesi Adana-Hematoloji
RECRUITING

Adana, 01250, Turkey (Türkiye)
Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118-2393, United States
CHU - UVC Brugmann
NOT_YET_RECRUITING

Brussels, 1020, Belgium
CHU Saint-Pierre - UMC Sint-Pieter
RECRUITING

Brussels, 1000, Belgium
CHUM-Hosp de Univ Montreal
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon
RECRUITING

Grenoble, 38043, France
Centre Hospitalier Universitaire de Bordeaux-Hopital Pellegrin
RECRUITING

Bordeaux, 33000, France
Centre Hospitalier Universitaire de Rouen-Hopital Charles Nicolle
NOT_YET_RECRUITING

Rouen, 76031, France
Centre of Excellence for Sickle Cell Disease Research and Training, University of Abuja (CESRTA)
NOT_YET_RECRUITING

Abuja, Federal Capital Territory (fct), 90410, Nigeria
Centro de investigaciones clínicas, fudación valle del lili
NOT_YET_RECRUITING

Cali, Valle del Cauca Department, 760032, Colombia
Centro de investigaciones clínicas, fudación valle del lili
NOT_YET_RECRUITING

Cali, 760032, Colombia
Children's Healthcare Atlanta
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hosp-New Orleans
RECRUITING

New Orleans, Louisiana, 70118, United States
Children's Hospital Los Angeles - Endocrinology
RECRUITING

Los Angeles, California, 90027, United States
Children's Hosptl Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hsptl Of The Kings
RECRUITING

Norfolk, Virginia, 23507, United States
Children's Nebraska
RECRUITING

Omaha, Nebraska, 68114, United States
Childrens Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Childrens National Medical Ctr
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Childrens' Hospital of Athens "Agia Sofia"
RECRUITING

Athens, 115 27, Greece
Clinica de la Costa
RECRUITING

Barranquilla, Atlántico, 80020, Colombia
Clinical and Transl Res Center
COMPLETED

Aurora, Colorado, 80045, United States
Clínica IMAT Oncomedica Auna S.A.S.
NOT_YET_RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Clínica IMAT Oncomedica Auna S.A.S.
NOT_YET_RECRUITING

Montería, 230002, Colombia
Cohen Children's Medical Ctr
RECRUITING

Queens, New York, 11040, United States
Cure 4 the Kids Foundation
COMPLETED

Las Vegas, Nevada, 89135, United States
Duke Comprehen Sickle Cell
RECRUITING

Durham, North Carolina, 27710, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
East Carolina Univ-Greenville
RECRUITING

Greenville, North Carolina, 27834, United States
Erasmus MC
NOT_YET_RECRUITING

Rotterdam, 3015 GD, Netherlands
Fiona Stanley Hospital - Haemophilia and Haemostasis Centre
RECRUITING

Murdoch, Western Australia, 6150, Australia
Fondazione IRCCS San Gerardo dei Tintori
NOT_YET_RECRUITING

Monza, 20900, Italy
Foothills Med Ctr-Univ Calgary
RECRUITING

Calgary, Alberta, T2N 2T9, Canada
Fundação Hemocentro de Ribeirão Preto
RECRUITING

Ribeirão Preto, São, 14051-140, Brazil
Gauhati Medical College and Hospital
RECRUITING

Guwahati, Assam, 781032, India
Gertrude's Children's Hospital
NOT_YET_RECRUITING

Nairobi, Nairobi County, 00509, Kenya
Government Medical College, Kozhikode
RECRUITING

Kozhikode, Kerala, 673008, India
Government Medical College, Kozhikode
NOT_YET_RECRUITING

Kozhikode, Kerala, 673008, India
Guy's Hospital - Haematology
NOT_YET_RECRUITING

London, SE1 9RT, United Kingdom
HC da FMUSP Hospital das Clínicas São Paulo
RECRUITING

São Paulo, São Paulo, 05403-010, Brazil
HC da FMUSP Hospital das Clínicas São Paulo
NOT_YET_RECRUITING

São Paulo, São Paulo, 05403-010, Brazil
HOCC Haemato Oncology Care Centre
RECRUITING

Vadodara, Gujarat, 390020, India
HUB - Hôpital Erasme
RECRUITING

Brussels, 1070, Belgium
Hacettepe University Hematology
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hacettepe Üniversitesi Hastanesi- Hematoloji
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Haga Ziekenhuis
RECRUITING

The Hague, 2545AA, Netherlands
Harbor-UCLA Medical Center
RECRUITING

Torrance, California, 90502, United States
Hemocentro UNICAMP
RECRUITING

Distrito de Barão Geraldo - Campinas, São Paulo, 13083-878, Brazil
Hemorio-Fundarj
RECRUITING

Rio de Janeiro, 20211-030, Brazil
Henry Ford Hospital_Detroit
COMPLETED

Detroit, Michigan, 48202, United States
Hippokration Hospital
RECRUITING

Athens, 11527, Greece
Hippokration Hospital
NOT_YET_RECRUITING

Athens, 11527, Greece
Hospices Civils de Lyon-Hopital Edouard Herriot
RECRUITING

Lyon, 69437, France
Hospital Gregorio Marañón
RECRUITING

Madrid, 28009, Spain
Hospital Nini
NOT_YET_RECRUITING

Tripoli, 1434, Lebanon
Hospital Pablo Tobon Uribe
NOT_YET_RECRUITING

Medellín, Antioquia, 50034, Colombia
Hospital Samaritano Higienópolis - Instituto de Conhecimento Ensino e Pesquisa (ICEP)
RECRUITING

São Paulo, 01229-001, Brazil
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hospital Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Vall d'Hebron
NOT_YET_RECRUITING

Barcelona, 08035, Spain
IMS and SUM Hospital
RECRUITING

Bhubaneswar, Odisha, 751003, India
Imperial College London
RECRUITING

London, W12 0NN, United Kingdom
Inova Health System
RECRUITING

Fairfax, Virginia, 22031, United States
Interfaith Medical Center
RECRUITING

Brooklyn, New York, 11238, United States
International Cancer Institute (ICI)
NOT_YET_RECRUITING

Eldoret, Uasin Gishu County, 8088-30100, Kenya
JSS Hospital, Mysore
RECRUITING

Mysuru, Karnataka, 570004, India
Jacobi Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Jinja Regional Referral Hospital
NOT_YET_RECRUITING

Jinja, Eastern Region, 0000, Uganda
Joint Clinical Research Centre (JCRC)
NOT_YET_RECRUITING

Kampala, Central Region (Wakiso District), 00000, Uganda
KEMRI CRDR Siaya Clinical Research Annex, Country Referral Hospital
NOT_YET_RECRUITING

Siaya, Siaya County, 40600, Kenya
King Abdulaziz Hospital-Al Ahsa-National Guard
RECRUITING

Al Ahsa, 36428, Saudi Arabia
King Faisal Specialist Hospital & Research Centre, Riyadh
RECRUITING

Riyadh, 12713, Saudi Arabia
King's College Hospital - Paediatric Research
RECRUITING

London, SE5 9RS, United Kingdom
Kings College Hospital - Haematology
RECRUITING

London, SE5 9RS, United Kingdom
Kintampo Health Research Centre (KHRC)
NOT_YET_RECRUITING

Kintampo, Bono East, 27WF+98M, Ghana
LHSC - Victoria Hospital
RECRUITING

London, Ontario, N6A5W9, Canada
Lagos University Teaching Hospital, Lagos
NOT_YET_RECRUITING

Lagos, 102215, Nigeria
Makerere University College of Health Sciences (MakCHS)
NOT_YET_RECRUITING

Kampala, Central Region, 00000, Uganda
Mary Bridge Children's Health
RECRUITING

Tacoma, Washington, 98405, United States
Mary Bridge Children's Health
NOT_YET_RECRUITING

Tacoma, Washington, 98405, United States
MedStar Hlth Res Institute
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Memorial Healthcare
RECRUITING

Hollywood, Florida, 33021, United States
Mersin University Medical Faculty Pediatric Hematology
NOT_YET_RECRUITING

Mersin, 33110, Turkey (Türkiye)
Mersin Üniversitesi Tip Fakültesi Hastanesi- Çiftlikköy Yerleşkesi- Hematoloji
RECRUITING

Mersin, 33110, Turkey (Türkiye)
Methodist University Hospital
RECRUITING

Memphis, Tennessee, 38104, United States
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
Montefiore Medical Ctr
RECRUITING

The Bronx, New York, 10467, United States
Montreal Children's Hospital
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
MultiHemo - Grupo Oncoclínicas
NOT_YET_RECRUITING

Recife, Pernambuco, 50070-460, Brazil
MultiHemo - Grupo Oncoclínicas
NOT_YET_RECRUITING

Recife, Pernambuco, 52070-460, Brazil
NIZAM'S Institute of Medical Sciences
RECRUITING

Hyderabad, Telangana, 500082, India
NYC Health+Hospitals
RECRUITING

Brooklyn, New York, 11203, United States
National Guard Hospital Dammam
RECRUITING

Dhahran, 34232, Saudi Arabia
Navrongo Health Research Centre
NOT_YET_RECRUITING

Navrongo, Upper East Region, UB-03821, Ghana
Nemours/AI duPont Hosp-Chld
RECRUITING

Wilmington, Delaware, 19803, United States
Newark Beth Israel Medical Center
NOT_YET_RECRUITING

Newark, New Jersey, 07112-2027, United States
Nirmal Hospital Pvt. Ltd.
RECRUITING

Surat, Gujarat, 395002, India
Northwell Health
COMPLETED

Mount Kisco, New York, 10549, United States
Ohio State Univ Wexner Med Ctr
RECRUITING

Columbus, Ohio, 43203, United States
Phoenix Children's Hsptl
RECRUITING

Phoenix, Arizona, 85016, United States
Post Graduate Institute of Child Health
RECRUITING

Noida, Uttar Pradesh, 201303, India
Prince of Wales Hospital - Department of Haematology
RECRUITING

Randwick, New South Wales, 2031, Australia
RNT Medical College
NOT_YET_RECRUITING

Udaipur, Rajasthan, 313001, India
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
SSG Hospital, Baroda
RECRUITING

Vadodara, Gujarat, 390001, India
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC)
RECRUITING

Valledupar, Cesar Department, 200001, Colombia
Sociedad de Oncología y Hematología del Cesar SAS (SOHEC)
NOT_YET_RECRUITING

Antioquia, 4006, Colombia
St Christopher Hosp for Child
RECRUITING

Philadelphia, Pennsylvania, 19134, United States
St. Jude Children's Res Hosp
RECRUITING

Memphis, Tennessee, 38105, United States
Stanford University_Palo Alto
RECRUITING

Palo Alto, California, 94304, United States
Stollery Children's Hospital
NOT_YET_RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
Sultan Qaboos University Hospital
RECRUITING

Muscat, Sultanet of Oman/Muscat/Al Khoud, 123, Oman
The Royal Hospital
COMPLETED

Muscat, 111, Oman
UCLA Health
RECRUITING

Los Angeles, California, 90095, United States
UHN-Toronto General Hospital
COMPLETED

Toronto, Ontario, M5G 2C4, Canada
UMC Utrecht, Van Creveldkliniek
RECRUITING

Utrecht, 3584 CX, Netherlands
UT Health University of Texas
RECRUITING

Houston, Texas, 77030, United States
UZ Antwerpen - UZA - Haematology
NOT_YET_RECRUITING

Edegem, 2650, Belgium
UZ Antwerpen - UZA - Kinderhemato-Oncologie
RECRUITING

Edegem, 2650, Belgium
UZ Leuven - Kindergeneeskunde
RECRUITING

Leuven, 3000, Belgium
Uni of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
Univ Hosp Cleveland Med Ctr
RECRUITING

Cleveland, Ohio, 44106, United States
Univ of OK Health Sciences Ctr
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
Univer Of Illinois at Chicago
RECRUITING

Chicago, Illinois, 60612, United States
Univer South Alabama Ped/Onc
RECRUITING

Mobile, Alabama, 36604, United States
University College Hospital Paediatric Haematology and Oncology Unit, Ibadan
NOT_YET_RECRUITING

Ibadan, Oyo State, 0000, Nigeria
University General Hospital Of Ioannina
RECRUITING

Ioannina, 45500, Greece
University General Hospital Of Ioannina
NOT_YET_RECRUITING

Ioannina, 45500, Greece
University Of California Irvine
COMPLETED

Orange, California, 92868, United States
University of Alberta_Edmonton
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Nigeria Teaching Hospital (UNTH)
NOT_YET_RECRUITING

Ituku-Ozalla, Enugu State, 400001, Nigeria
University of Toronto
NOT_YET_RECRUITING

Toronto, Ontario, M5G1X8, Canada
VM Medical Park Mersin Hastanesi- Kardiyoloji
RECRUITING

Mersin, 33200, Turkey (Türkiye)
Valley Children's Hospital
RECRUITING

Madera, California, 93636, United States
Virginia Comm Univ Medical Ctr
RECRUITING

Richmond, Virginia, 23298, United States
Washington University-St.Louis
RECRUITING

St Louis, Missouri, 63110, United States
Whittington Hospital
RECRUITING

London, N19 5NF, United Kingdom
Zydus Medical College & Hospital
RECRUITING

Dohad, Gujarat, 389151, India
Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi- Hematoloji
RECRUITING

Adana, 01250, Turkey (Türkiye)

Conditions

Explore the condition pages connected to this study.

SICKLE CELL DISEASE