New drug cocktail aims to wipe out esophageal cancer before surgery
NCT ID NCT07490002
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial is testing whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) and a targeted therapy (lenvatinib) to standard chemotherapy before surgery can improve outcomes for people with resectable esophageal squamous cell carcinoma. The main goal is to see how many patients have no cancer cells left in their surgical specimen (pathological complete response). The study will enroll 33 participants and is not yet recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
iparomlimab, tuvonralimab, lenvatinib, cisplatin/carboplatin, nab-paclitaxel
What this could lead to
If successful, this could lead to a more effective pre-surgery treatment for esophageal cancer, potentially increasing the chance of eliminating all cancer before surgery.
What could go wrong
This is a small, early-phase study (33 people) with no control group, so results may not be definitive. The drug combination may cause significant side effects and may not improve outcomes compared to standard care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••