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Immunotherapy showdown: can new drug combos extend lives in tough esophageal cancer?

NCT ID NCT03143153

Completed Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

Summary

This large study tested whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to standard chemotherapy could help people with advanced esophageal cancer live longer or delay cancer growth. It involved 970 adults whose cancer couldn't be removed by surgery and had either returned or spread. Researchers compared survival and time without disease progression between the new combinations and standard treatment alone.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Arizona Cancer Center

    Tucson, Arizona, 85724, United States

  • Hackensack Meridian Jersey Shore University Medical Center

    Neptune City, New Jersey, 07753, United States

  • Local Institution - 0006

    Nový Jičín, 741 01, Czechia

  • Local Institution - 0008

    Brno, 656 53, Czechia

  • Local Institution - 0010

    Murdoch, Western Australia, 6150, Australia

  • Local Institution - 0011

    Douglas, Queensland, 4814, Australia

  • Local Institution - 0016

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Local Institution - 0017

    Salvador, Estado de Bahia, 41950-640, Brazil

  • Local Institution - 0018

    São José do Rio Preto, São Paulo, 15090000, Brazil

  • Local Institution - 0019

    Barretos, São Paulo, 14780-070, Brazil

  • Local Institution - 0020

    São Paulo, São Paulo, 01246-000, Brazil

  • Local Institution - 0021

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Local Institution - 0022

    Warsaw, 02-781, Poland

  • Local Institution - 0024

    Lublin, 20-081, Poland

  • Local Institution - 0028

    Houston, Texas, 77030, United States

  • Local Institution - 0029

    Surrey, SM2 5PT, United Kingdom

  • Local Institution - 0031

    Manchester, Greater Manchester, M20 4BX, United Kingdom

  • Local Institution - 0032

    Marietta, Georgia, 30060, United States

  • Local Institution - 0033

    Singapore, Central Singapore, 168583, Singapore

  • Local Institution - 0034

    Singapore, 119228, Singapore

  • Local Institution - 0035

    Hong Kong, 0, Hong Kong

  • Local Institution - 0037

    Trois-Rivières, Quebec, G8Z 3R9, Canada

  • Local Institution - 0039

    Milan, 20133, Italy

  • Local Institution - 0048

    Buenos Aires, Buenos Aires, 1417, Argentina

  • Local Institution - 0050

    Capital Federal, Buenos Aires, 1264, Argentina

  • Local Institution - 0053

    Santiago, Santiago Metropolitan, 8320000, Chile

  • Local Institution - 0058

    Medellín, 050034, Colombia

  • Local Institution - 0059

    Bogotá, Bogota D.C., 0, Colombia

  • Local Institution - 0060

    Lima, Lima Province, 34, Peru

  • Local Institution - 0062

    Madrid, 28050, Spain

  • Local Institution - 0063

    Barcelona, 08035, Spain

  • Local Institution - 0066

    London, Greater London, SW3 6JJ, United Kingdom

  • Local Institution - 0069

    London, Greater London, NW1 2PG, United Kingdom

  • Local Institution - 0070

    Kowloon, Hong Kong

  • Local Institution - 0071

    Mérida, Yucatán, 97138, Mexico

  • Local Institution - 0074

    Atlanta, Georgia, 30322, United States

  • Local Institution - 0076

    Craiova, 200347, Romania

  • Local Institution - 0079

    Cluj-Napoca, 400015, Romania

  • Local Institution - 0080

    Suceava, 720237, Romania

  • Local Institution - 0081

    Bucharest, 021389, Romania

  • Local Institution - 0082

    Montreal, Quebec, H3T 1E2, Canada

  • Local Institution - 0083

    Brno, 625 00, Czechia

  • Local Institution - 0084

    Padua, Padova, Italy

  • Local Institution - 0085

    Bergamo, 24127, Italy

  • Local Institution - 0086

    Rosario, Santa Fe Province, 2000, Argentina

  • Local Institution - 0087

    La Rioja, La Rioja Province, 5300, Argentina

  • Local Institution - 0088

    Saint Petersburg, 198255, Russia

  • Local Institution - 0089

    Moscow, 121309, Russia

  • Local Institution - 0090

    Tuxtla Gutiérrez, Chiapas, 29038, Mexico

  • Local Institution - 0092

    Callao, Provincia Constitucional del Callao, 02, Peru

  • Local Institution - 0093

    Lima, Lima Province, Lima 11, Peru

  • Local Institution - 0094

    Pereira, 660004, Colombia

  • Local Institution - 0095

    Moncton, New Brunswick, E1C 6Z8, Canada

  • Local Institution - 0096

    Ankara, 06100, Turkey (Türkiye)

  • Local Institution - 0098

    Sayama, Osaka, 589-8511, Japan

  • Local Institution - 0099

    Odense, 5000, Denmark

  • Local Institution - 0100

    Hiroshima, Hiroshima, 7348551, Japan

  • Local Institution - 0101

    Chiba, Chiba, 260-8717, Japan

  • Local Institution - 0102

    Mexico City, Mexico City, 14000, Mexico

  • Local Institution - 0103

    Fukushima, Fukushima, 9601295, Japan

  • Local Institution - 0104

    Hirosaki-shi, Aomori, 0368563, Japan

  • Local Institution - 0105

    Sagamihara-shi, Kanagawa, 2520375, Japan

  • Local Institution - 0106

    Bunkyo-ku, Tokyo, 1138519, Japan

  • Local Institution - 0107

    Suita, Osaka, 5650871, Japan

  • Local Institution - 0108

    Shizuoka, Shizuoka, 4208527, Japan

  • Local Institution - 0109

    Kawasaki-shi, Kanagawa, 216-8511, Japan

  • Local Institution - 0110

    Bunkyo-ku, Tokyo, 1138677, Japan

  • Local Institution - 0111

    Sapporo, Hokkaido, 060-8648, Japan

  • Local Institution - 0112

    Montpellier, 34090, France

  • Local Institution - 0113

    Rennes, 35042, France

  • Local Institution - 0114

    Caen, 14076, France

  • Local Institution - 0115

    Villejuif, 94800, France

  • Local Institution - 0116

    Lille, Nord, 59000, France

  • Local Institution - 0117

    Yokohama, Kanagawa, 2418515, Japan

  • Local Institution - 0118

    Kobe, Hyōgo, 6500047, Japan

  • Local Institution - 0119

    Matsuyama, Ehime, 7910280, Japan

  • Local Institution - 0120

    Kamigyō-ku, Kyoto, 602-8566, Japan

  • Local Institution - 0122

    Edrine, 22010, Turkey (Türkiye)

  • Local Institution - 0123

    Seoul, 120-752, South Korea

  • Local Institution - 0124

    Taipei, 100, Taiwan

  • Local Institution - 0125

    Diyarbakır, 21280, Turkey (Türkiye)

  • Local Institution - 0126

    Koto-ku, Tokyo, 1358550, Japan

  • Local Institution - 0127

    Isehara, Kanagawa, 259-1193, Japan

  • Local Institution - 0128

    Chuo-ku, Tokyo, 1048560, Japan

  • Local Institution - 0129

    Seongnam-si, Kyǒnggi-do, 13620, South Korea

  • Local Institution - 0130

    Seoul, 05505, South Korea

  • Local Institution - 0131

    Seoul, 08308, South Korea

  • Local Institution - 0132

    Taichung, 40447, Taiwan

  • Local Institution - 0133

    Kaohsiung City, 833, Taiwan

  • Local Institution - 0134

    Taipei, 11217, Taiwan

  • Local Institution - 0135

    Kurashiki-shi, Okayama-ken, 7010192, Japan

  • Local Institution - 0136

    Chuo-ku, Tokyo, 1040045, Japan

  • Local Institution - 0137

    Okayama, Okayama-ken, 7008558, Japan

  • Local Institution - 0138

    Osaka, Osaka, 5418567, Japan

  • Local Institution - 0139

    Takatsuki, Osaka, 569-8686, Japan

  • Local Institution - 0140

    Shinagawa-ku, Tokyo, 142-8666, Japan

  • Local Institution - 0141

    Kumamoto, Kumamoto, 8608556, Japan

  • Local Institution - 0142

    Fukuoka, Fukuoka, 8128582, Japan

  • Local Institution - 0143

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Local Institution - 0144

    Sendai, Miyagi, 9808575, Japan

  • Local Institution - 0145

    Kyoto, Kyoto, 606-8507, Japan

  • Local Institution - 0146

    Niigata, Niigata, 9518566, Japan

  • Local Institution - 0147

    Yokohama, Kanagawa, 2360004, Japan

  • Local Institution - 0148

    Shimotsuga-gun, Tochigi, 321-0293, Japan

  • Local Institution - 0149

    Daejeon, 35015, South Korea

  • Local Institution - 0150

    Daegu, 41404, South Korea

  • Local Institution - 0151

    Seoul, 07345, South Korea

  • Local Institution - 0152

    Akita, Akita, 010-8543, Japan

  • Local Institution - 0153

    Chiba, Chiba, 2608670, Japan

  • Local Institution - 0154

    Gifu, Gifu, 5011194, Japan

  • Local Institution - 0155

    Shinjuku-ku, Tokyo, 1628666, Japan

  • Local Institution - 0156

    Minato-ku, Tokyo, 1058470, Japan

  • Local Institution - 0157

    Ulsan, 44033, South Korea

  • Local Institution - 0158

    Changhua County, Changhua, 50006, Taiwan

  • Local Institution - 0159

    Taoyuan District, 333, Taiwan

  • Local Institution - 0160

    Tainan, 71004, Taiwan

  • Local Institution - 0161

    Tainan, TNN, 704, Taiwan

  • Local Institution - 0162

    Taipei, 10449, Taiwan

  • Local Institution - 0163

    Kaohsiung County, 0, Taiwan

  • Local Institution - 0164

    Keelung, 204, Taiwan

  • Local Institution - 0165

    Seoul, Seoul-teukbyeolsi [Seoul], 02841, South Korea

  • Local Institution - 0166

    Busan, 49241, South Korea

  • Local Institution - 0167

    Kaohsiung City, 807, Taiwan

  • Local Institution - 0168

    Seoul, 06591, South Korea

  • Local Institution - 0169

    Matsuyama, Ehime, 7900024, Japan

  • Local Institution - 0170

    Akashi-shi, Hyōgo, 6738558, Japan

  • Local Institution - 0171

    Kanazawa, Ishikawa-ken, 920-8530, Japan

  • Local Institution - 0172

    Kobe, Hyōgo, 6500017, Japan

  • Local Institution - 0173

    Kashiwa-shi, Chiba, 2778577, Japan

  • Local Institution - 0174

    Fukuoka, Fukuoka, 8111395, Japan

  • Local Institution - 0175

    Kitaadachi-gun, Saitama, 3620806, Japan

  • Local Institution - 0176

    Ōta, Gunma, 3738550, Japan

  • Local Institution - 0177

    Seoul, 06351, South Korea

  • Local Institution - 0178

    Wakayama, Wakayama, 641-8510, Japan

  • Local Institution - 0179

    Beijing, Beijing Municipality, 100071, China

  • Local Institution - 0180

    Changchun, Jilin, 130021, China

  • Local Institution - 0182

    Beijing, Beijing Municipality, 100032, China

  • Local Institution - 0183

    Xi'an, Shan3xi, 710038, China

  • Local Institution - 0184

    Hangzhou, Zhejiang, 310003, China

  • Local Institution - 0185

    Harbin, Heilongjiang, 155040, China

  • Local Institution - 0186

    Miami, Florida, 33176, United States

  • Local Institution - 0188

    Denver, Colorado, 80218, United States

  • Local Institution - 0190

    Roanoke, Virginia, 24014, United States

  • Local Institution - 0191

    Mobile, Alabama, 36608, United States

  • Local Institution - 0193

    Zhengzhou, Henan, 0, China

  • Local Institution - 0194

    Zhengzhou, Henan, 450052, China

  • Local Institution - 0195

    Zhengzhou, Henan, 450008, China

  • Local Institution - 0196

    Shinjuku-Ku, Tokyo, 1608582, Japan

  • Local Institution - 0197

    Hefei, Anhui, 230061, China

  • Local Institution - 0199

    Shantou, Guangdong, 515041, China

  • Local Institution - 0200

    Shanghai, Shanghai Municipality, 200032, China

  • Local Institution - 0201

    Nanjing, Jiangsu, 210000, China

  • Local Institution - 0203

    Morgantown, West Virginia, 26506-9162, United States

  • Local Institution - 0207

    Hefei, Anhui, 230022, China

  • Local Institution - 0210

    Dallas, Texas, 75246, United States

  • Local Institution - 0212

    Changsha, Hunan, 410008, China

  • Local Institution - 0214

    Santiago, Santiago Metropolitan, Chile

  • Local Institution - 0215

    Shanghai, Shanghai Municipality, 200030, China

  • Local Institution - 0216

    Beijing, Beijing Municipality, 100853, China

  • Local Institution - 0217

    Fuzhou, Fujian, 350014, China

  • Local Institution - 0219

    Fuzhou, Fujian, 350025, China

  • Local Institution - 0220

    Shenyang, 110042, China

  • Local Institution - 0221

    Hirakata, Osaka, 573-1191, Japan

  • Local Institution - 0222

    Montreal, Quebec, H4A 3J1, Canada

  • Local Institution - 0224

    Montería, 230001, Colombia

  • Local Institution - 0225

    Tampa, Florida, 33612, United States

  • Local Institution - 0226

    Jaú, São Paulo, 17210-080, Brazil

  • Local Institution - 0227

    Ipatinga, Minas Gerais, 35160-158, Brazil

  • Local Institution - 0228

    Rio de Janeiro, Rio de Janeiro, 22793-080, Brazil

  • Local Institution - 0229

    Kagoshima, Kagoshima-ken, 8908520, Japan

  • Local Institution - 0230

    Hidaka-shi, Saitama, 3501298, Japan

  • Local Institution - 0231

    Toyama, Toyama, 9300194, Japan

  • Local Institution - 0232

    Tamworth, New South Wales, 2340, Australia

  • Local Institution - 0234

    San Luis Potosí City, San Luis Potosí, 78200, Mexico

  • Local Institution - 0235

    Seoul, 01812, South Korea

  • Local Institution - 0236

    Jeonju, 54907, South Korea

  • Local Institution - 0237

    London, EC1A 7BE, United Kingdom

  • Local Institution - 0238

    Ube-shi, Yamaguchi, 7558505, Japan

  • Local Institution - 0240

    Pisa, 56126, Italy

  • Local Institution - 0241

    Salzburg, 5020, Austria

  • Local Institution - 0242

    Toulouse, 31059, France

  • Local Institution - 0243

    Porto, Porto District, 4200-072, Portugal

  • Local Institution - 0245

    Ōta-ku, Tokyo, 1438541, Japan

  • Local Institution - 0247

    Linhai, Zhejiang, 317000, China

  • Local Institution - 0248

    Xi'an, 0, China

  • Local Institution - 0249

    Changsha, Hunan, 410000, China

  • Northwest Cancer Specialists, P.C.

    Portland, Oregon, 97227, United States

  • Oncology Associates Of Oregon, Pc

    Eugene, Oregon, 97401, United States

  • University Of Miami Sylvester Comprehensive Cancer Center

    Miami, Florida, 33136, United States

  • Usc/Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

Conditions

Explore the condition pages connected to this study.

VARIOUS ADVANCED CANCER