Can a single dose of esketamine stop itching in older surgery patients?
NCT ID NCT07597486
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a low dose of esketamine, given during knee replacement surgery, can reduce itching in elderly patients with senile pruritus. Two hundred participants will receive either esketamine or a placebo, and their itching will be measured over the following week. The goal is to see if this drug can provide relief without major side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Esketamine
- What this could lead to
- If it works, this could offer a new way to ease severe itching in older adults during and after surgery.
- What could go wrong
- This is a small, early-stage trial with only 200 participants. It may not show a clear benefit, and esketamine can cause side effects like dizziness or nausea.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tianjin Medical University General Hospital
Tianjin, 300052, China