Could a surgical anesthetic calm unbearable Liver-Related itching?
NCT ID NCT07760740
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial asks whether giving esketamine during surgery can reduce the intense itching caused by cholestasis, a condition where bile flow is blocked. About 100 patients undergoing hepatobiliary surgery will receive either esketamine or a placebo infusion. Researchers will track itching scores for the first three days after surgery to see if esketamine provides relief.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Esketamine, given as a continuous infusion during surgery
- What this could lead to
- If effective, esketamine could offer a new way to relieve severe itching in patients with cholestasis, improving comfort after surgery.
- What could go wrong
- This is a small, early-stage trial, and the effect on itching is uncertain. Esketamine may cause side effects like nausea or dizziness, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Tianjin Medical University General Hospital, Tianjin, 300052
Tianjin, China