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A common drug may prevent Anesthesia-Induced low blood pressure in High-Risk surgery patients

NCT ID NCT07722013

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This trial tests whether giving small, repeated doses of ephedrine during anesthesia induction can prevent dangerously low blood pressure in patients over 50 undergoing major abdominal surgery. Participants will receive either ephedrine or a placebo (saline) every five minutes for 20 minutes after anesthesia begins. The goal is to see if this simple preventive strategy reduces the need for emergency blood pressure support.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ephedrine given as intermittent boluses during anesthesia induction
What this could lead to
If effective, this simple preventive approach could reduce complications from low blood pressure during surgery in older or frail patients.
What could go wrong
This is a single-center trial with 124 participants, so results may not apply broadly. Ephedrine can raise heart rate and blood pressure, which may be risky for some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 124 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged \>50 years, * weight \>50 kg, * American Society of Anesthesiologists (ASA) Physical Status score of \> I, * undergoing major abdominal surgery Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 40%, heart block, significant uncontrolled arrhythmias, tight stenotic valvular lesions) * Acute cardiovascular pathologies: acute/decompensated heart failure, acute coronary syndrome * Uncontrolled hypertension (systolic blood pressure\>150 mmHg) * Preoperative HR more than 110 bpm despite proper fluid management and patients with renal impairment * Renal impairment * Patients on vasopressor infusion, * Allergy of any of the study drugs

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postinduction hypotension

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Kasr Alainy Hospital

    RECRUITING

    Cairo, 11562, Egypt

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