New pill shows promise in reducing pain crises for sickle cell patients
NCT ID NCT05861453
First seen Nov 01, 2025 · Last updated May 07, 2026 · Updated 28 times
Summary
This study tested an oral medication called epeleuton in 35 adults with sickle cell disease. The goal was to see how the drug moves through the body, how it affects blood cells, and if it can reduce painful vaso-occlusive crises. Participants took the drug for 16 weeks, and researchers measured changes in crisis rates, blood markers, and quality of life.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta at Arthur M. Blank Hospital
Atlanta, Georgia, 30329, United States
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Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta at Hughes Spalding
Atlanta, Georgia, 30303, United States
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Emory University - Georgia Comprehensive Sickle Cell Center
Atlanta, Georgia, 30303, United States
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Jacobi Medical Center
The Bronx, New York, 10461, United States
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Kaiser Permanente Mid-Atlantic States
Largo, Maryland, 20774, United States
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Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Medstar Health
Washington D.C., District of Columbia, 20010, United States
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New England Sickle Cell Institute, UConn Health
Farmington, Connecticut, 06030-1163, United States
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Newark Beth Israel Medical Center
Newark, New Jersey, 07112, United States
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Robert Wood Johnson Medical School Rutgers
New Brunswick, New Jersey, 08901, United States
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Science 37
Morrisville, North Carolina, 27560, United States
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St Paul's Hospital Hematology/Oncology Research
Vancouver, British Columbia, V6E 1M7, Canada
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The Center for Cancer and Blood Disorders, A Division of American Oncology Partners, PA
Bethesda, Maryland, 20817, United States
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The Johns Hopkins University School of Medicine
Baltimore, Maryland, 21205, United States
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Toronto General Hospital
Toronto, Ontario, M5G 2C4, Canada
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UI Health Sickle Cell Center
Chicago, Illinois, 60612, United States
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UNC Health
Chapel Hill, North Carolina, 27517, United States
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University of Alabama at Birmingham (UAB)
Birmingham, Alabama, 35294, United States
Conditions
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