New hope for kids with tough cancers: targeted drug trial shows promise
NCT ID NCT02650401
Summary
This study is testing a drug called entrectinib in children and adolescents with advanced solid tumors or brain cancers that have come back or not responded to other treatments. The main goals are to find the safest and most effective dose and to see if the drug helps shrink tumors, especially in patients whose cancers have specific genetic changes (NTRK or ROS1 gene fusions). The trial is for young patients who have no other satisfactory treatment options.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beijing Children's Hospital, Capital Medical University
Beijing, China
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Centre Leon Berard
Lyon, 69373, France
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Egleston Children's Hospital at Emory University Atlanta
Atlanta, Georgia, 30322, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Lombardy, 20133, Italy
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Hong Kong Children's Hospital
Hong Kong, 00000, Hong Kong
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Hospital Infantil Universitario Nino Jesus
Madrid, 28009, Spain
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Hôpital de la Timone, Oncologie Pédiatrique
Marseille, 13385, France
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Johns Hopkins University
Baltimore, Maryland, 21205, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Oregon Health & Science Uni
Portland, Oregon, 97239, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Royal Marsden Hospital (Sutton)
London, SW3 6JJ, United Kingdom
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Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP, United Kingdom
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St. Jude Children'S Research Hospital
Memphis, Tennessee, 38105, United States
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Texas Children's Cancer and Hematology Center
Houston, Texas, 77030, United States
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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UCSF Benioff Children's Hospital
San Francisco, California, 94158, United States
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Universitaetsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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University of California San Diego
La Jolla, California, 92093-0706, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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Washington University,St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
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Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 200082, China
Conditions
Explore the condition pages connected to this study.