New pill could ease lupus skin rashes in major trial

NCT ID NCT07355218

Recruiting now Disease control Sponsor: EMD Serono Research & Development Institute, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This study tests a drug called enpatoran for people with lupus who have active skin rashes or lesions. About 202 participants will take either enpatoran or a placebo twice daily for 24 weeks, alongside their usual treatments. The goal is to see if the drug can significantly improve skin symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Enpatoran (a drug taken as a tablet twice daily)
What this could lead to: If it works, this could offer a new treatment option for people with lupus-related skin rashes and lesions, potentially reducing their severity.
What could go wrong: This is an early Phase 3 trial with only 202 participants, so results may not apply to everyone. The drug may not prove more effective than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous lupus erythematosus discoid lupus erythematosus systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUTANEOUS LUPUS ERYTHEMATOSUS SYSTEMATIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

Accurate Clinical Research
RECRUITING

Humble, Texas, 77346, United States
Accurate Clinical Research Inc. - Lake Charles
RECRUITING

Lake Charles, Louisiana, 70605, United States
Arthritis and Osteoporosis Consultants of the Carolinas II, LLC
RECRUITING

Charlotte, North Carolina, 28207, United States
Bolanos Clinical Research
RECRUITING

Pembroke Pines, Florida, 33026, United States
Dawes Fretzin Clinical Research Group, LLC
RECRUITING

Indianapolis, Indiana, 46250, United States
GTL Medical And Research Group
RECRUITING

Miami, Florida, 33173, United States
Inland Rheumatology Clinical Trials, Inc.
RECRUITING

Upland, California, 91786, United States
North Texas Center for Clinical Research
RECRUITING

Frisco, Texas, 75034, United States
Oakland Hills Dermatology
RECRUITING

Auburn Hills, Michigan, 48326, United States
Omega Research Debary, LLC
RECRUITING

DeBary, Florida, 32713, United States
South Florida Rheumatology
RECRUITING

Hollywood, Florida, 33026, United States
The Medical Arts Health Research Group - 300128547
RECRUITING

Kelowna, British Columbia, V1Y 4Z5, Canada
Vantage Clinical Trials
RECRUITING

Tampa, Florida, 33603, United States

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