New drug cocktail shows promise for Tough-to-Treat endometrial cancer

NCT ID NCT07198074

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 25 times

Summary

This study tests whether adding a drug called bevacizumab to standard chemotherapy plus immunotherapy works better for advanced or recurrent endometrial cancer with specific genetic changes (pMMR and TP53 mutated). About 255 participants will receive one of three treatment combinations. The goal is to see which combination delays cancer growth and improves survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Abbott-Northwestern Hospital
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Minneapolis, Minnesota, 55407, United States

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Asplundh Cancer Pavilion
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Willow Grove, Pennsylvania, 19090, United States

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Augusta University Medical Center
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Augusta, Georgia, 30912, United States

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Benefis Sletten Cancer Institute
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Great Falls, Montana, 59405, United States

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Billings Clinic Cancer Center
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Billings, Montana, 59101, United States

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Bozeman Health Deaconess Hospital
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Bozeman, Montana, 59715, United States

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Camden Clark Medical Center
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Parkersburg, West Virginia, 26101, United States

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Cancer Care Specialists of Illinois - Decatur
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Decatur, Illinois, 62526, United States

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Cancer Center at Saint Joseph's
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Phoenix, Arizona, 85004, United States

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Case Western Reserve University
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Cleveland, Ohio, 44106, United States

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Columbus Oncology and Hematology Associates
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Dublin, Ohio, 43016, United States

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Columbus Oncology and Hematology Associates Inc
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Columbus, Ohio, 43214, United States

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Community Hospital of Anaconda
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Anaconda, Montana, 59711, United States

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Community Medical Center
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Missoula, Montana, 59804, United States

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CoxHealth South Hospital
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Springfield, Missouri, 65807, United States

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Dana-Farber Cancer Institute
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Boston, Massachusetts, 02215, United States

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Decatur Memorial Hospital
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Decatur, Illinois, 62526, United States

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Delaware Health Center-Grady Cancer Center
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Delaware, Ohio, 43015, United States

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Doctors Hospital
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Columbus, Ohio, 43228, United States

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Dublin Methodist Hospital
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Dublin, Ohio, 43016, United States

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Duluth Clinic Ashland
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Ashland, Wisconsin, 54806, United States

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East Jefferson General Hospital
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Metairie, Louisiana, 70006, United States

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Essentia Health - Deer River Clinic
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Deer River, Minnesota, 56636, United States

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Essentia Health Cancer Center
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Duluth, Minnesota, 55805, United States

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Essentia Health Cancer Center-South University Clinic
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Fargo, North Dakota, 58103, United States

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Essentia Health Hibbing Clinic
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Hibbing, Minnesota, 55746, United States

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Essentia Health Saint Joseph's Medical Center
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Brainerd, Minnesota, 56401, United States

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Essentia Health Saint Mary's Hospital - Superior
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Superior, Wisconsin, 54880, United States

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Essentia Health Sandstone
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Sandstone, Minnesota, 55072, United States

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Essentia Health Virginia Clinic
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Virginia, Minnesota, 55792, United States

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Essentia Health-Spooner Clinic
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Spooner, Wisconsin, 54801, United States

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Fred and Pamela Buffett Cancer Center - Kearney
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Kearney, Nebraska, 68845, United States

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Geauga Hospital
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Chardon, Ohio, 44024, United States

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Genesys Hurley Cancer Institute
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Flint, Michigan, 48503, United States

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Goshen Center for Cancer Care
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Goshen, Indiana, 46526, United States

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Grady Memorial Hospital
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Delaware, Ohio, 43015, United States

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Grant Medical Center
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Columbus, Ohio, 43215, United States

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Helen F Graham Cancer Center
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Newark, Delaware, 19713, United States

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Hurley Medical Center
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Flint, Michigan, 48503, United States

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Jefferson Torresdale Hospital
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Philadelphia, Pennsylvania, 19114, United States

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Johns Hopkins University/Sidney Kimmel Cancer Center
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Baltimore, Maryland, 21287, United States

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Kootenai Clinic Cancer Services - Post Falls
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Post Falls, Idaho, 83854, United States

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Kootenai Clinic Cancer Services - Sandpoint
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Sandpoint, Idaho, 83864, United States

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Kootenai Health - Coeur d'Alene
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Coeur d'Alene, Idaho, 83814, United States

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LSU Healthcare Network / Metairie Multi-Specialty Clinic
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Metairie, Louisiana, 70006, United States

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Legacy Good Samaritan Hospital and Medical Center
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Portland, Oregon, 97210, United States

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Legacy Meridian Park Hospital
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Tualatin, Oregon, 97062, United States

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Legacy Salmon Creek Hospital
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Vancouver, Washington, 98686, United States

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Medical Oncology Hematology Consultants PA
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Newark, Delaware, 19713, United States

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Memorial Hospital of South Bend
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South Bend, Indiana, 46601, United States

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Memorial Sloan Kettering Basking Ridge
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Basking Ridge, New Jersey, 07920, United States

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Memorial Sloan Kettering Bergen
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Montvale, New Jersey, 07645, United States

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Memorial Sloan Kettering Cancer Center
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New York, New York, 10065, United States

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Memorial Sloan Kettering Commack
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Commack, New York, 11725, United States

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Memorial Sloan Kettering Monmouth
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Middletown, New Jersey, 07748, United States

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Memorial Sloan Kettering Nassau
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Uniondale, New York, 11553, United States

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Memorial Sloan Kettering Westchester
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Harrison, New York, 10604, United States

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Mercy Cancer Center - Carmichael
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Carmichael, California, 95608, United States

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Mercy Cancer Center - Elk Grove
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Elk Grove, California, 95758, United States

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Mercy Cancer Center - Rocklin
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Rocklin, California, 95765, United States

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Mercy Cancer Center - Sacramento
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Sacramento, California, 95816, United States

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Mercy Hospital
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Cedar Rapids, Iowa, 52403, United States

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Mercy Hospital Springfield
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Springfield, Missouri, 65804, United States

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Mercy San Juan Medical Center
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Carmichael, California, 95608, United States

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Montefiore Medical Center - Moses Campus
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The Bronx, New York, 10467, United States

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Montefiore Medical Center-Einstein Campus
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The Bronx, New York, 10461, United States

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Montefiore Medical Center-Weiler Hospital
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The Bronx, New York, 10461, United States

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Nebraska Medicine-Bellevue
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Bellevue, Nebraska, 68123, United States

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Nebraska Medicine-Village Pointe
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Omaha, Nebraska, 68118, United States

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Nebraska Methodist Hospital
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Omaha, Nebraska, 68114, United States

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Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States

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Northwestern Medicine Cancer Center Kishwaukee
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DeKalb, Illinois, 60115, United States

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Northwestern Medicine Cancer Center Warrenville
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Warrenville, Illinois, 60555, United States

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Northwestern Medicine Oak Brook
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Oak Brook, Illinois, 60523, United States

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Northwestern Medicine Orland Park
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Orland Park, Illinois, 60462, United States

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Northwestern University
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Chicago, Illinois, 60611, United States

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OSF Saint Francis Hospital and Medical Group
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Escanaba, Michigan, 49829, United States

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OSF Saint Francis Medical Center
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Peoria, Illinois, 61637, United States

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Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

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OhioHealth Mansfield Hospital
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Mansfield, Ohio, 44903, United States

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OhioHealth Marion General Hospital
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Marion, Ohio, 43302, United States

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OhioHealth O'Bleness Hospital
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Athens, Ohio, 45701, United States

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OhioHealth Pickerington Methodist Hospital
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Pickerington, Ohio, 43147, United States

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OhioHealth Westerville Medical Campus/Westerville Cancer Center
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Westerville, Ohio, 43082, United States

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Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States

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Park Nicollet Clinic - Saint Louis Park
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Saint Louis Park, Minnesota, 55416, United States

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ProMedica Flower Hospital
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Sylvania, Ohio, 43560, United States

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Providence Portland Medical Center
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Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Riverside Methodist Hospital
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Columbus, Ohio, 43214, United States

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Rush MD Anderson Cancer Center
RECRUITING

Chicago, Illinois, 60612, United States

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Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States

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Rutgers New Jersey Medical School
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Newark, New Jersey, 07101, United States

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Saint Vincent Hospital Cancer Center Green Bay
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Green Bay, Wisconsin, 54301, United States

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Saint Vincent Hospital Cancer Center at Oconto Falls
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Oconto Falls, Wisconsin, 54154, United States

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Saint Vincent Hospital Cancer Center at Saint Mary's
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Green Bay, Wisconsin, 54303, United States

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Saint Vincent Hospital Cancer Center at Sheboygan
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Sheboygan, Wisconsin, 53081, United States

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Saint Vincent Hospital Cancer Center at Sturgeon Bay
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Sturgeon Bay, Wisconsin, 54235-1495, United States

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Sheboygan Physicians Group
RECRUITING

Sheboygan, Wisconsin, 53081, United States

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Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

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Southeastern Medical Oncology Center-Clinton
RECRUITING

Clinton, North Carolina, 28328, United States

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Southeastern Medical Oncology Center-Goldsboro
RECRUITING

Goldsboro, North Carolina, 27534, United States

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Southeastern Medical Oncology Center-Jacksonville
RECRUITING

Jacksonville, North Carolina, 28546, United States

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Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States

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Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States

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Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States

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Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States

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Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States

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Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States

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The Valley Hospital - Luckow Pavilion
RECRUITING

Paramus, New Jersey, 07652, United States

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Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States

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Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States

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Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States

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Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States

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Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States

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Trinity Health Saint Mary Mercy Livonia Hospital
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Livonia, Michigan, 48154, United States

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UH Seidman Cancer Center at Lake Health Mentor Campus
RECRUITING

Mentor, Ohio, 44060, United States

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UH Seidman Cancer Center at Saint John Medical Center
RECRUITING

Westlake, Ohio, 44145, United States

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UHHS-Chagrin Highlands Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States

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UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Cancer Center-Washington
RECRUITING

Washington, Pennsylvania, 15301, United States

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UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITING

Greensburg, Pennsylvania, 15601, United States

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UPMC Hillman Cancer Center Erie
RECRUITING

Erie, Pennsylvania, 16505, United States

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UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITING

Mechanicsburg, Pennsylvania, 17050, United States

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UPMC-Magee Womens Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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UPMC-Passavant Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15237, United States

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United Hospital Center
RECRUITING

Bridgeport, West Virginia, 26330, United States

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University Hospitals Parma Medical Center
RECRUITING

Parma, Ohio, 44129, United States

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University Medical Center New Orleans
RECRUITING

New Orleans, Louisiana, 70112, United States

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University of Alabama at Birmingham Cancer Center
RECRUITING

Birmingham, Alabama, 35233, United States

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University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States

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University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

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Contact Phone: •••-•••-•••• Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Valley Health System Ridgewood Campus
RECRUITING

Ridgewood, New Jersey, 07450, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
WVUH-Berkely Medical Center
RECRUITING

Martinsburg, West Virginia, 25401, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
West Jefferson Medical Center
RECRUITING

Marrero, Louisiana, 70072, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
West Virginia University Charleston Division
RECRUITING

Charleston, West Virginia, 25304, United States

Contact Phone: •••-•••-••••

Contact
West Virginia University Healthcare
RECRUITING

Morgantown, West Virginia, 26506, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Women and Infants Hospital
RECRUITING

Providence, Rhode Island, 02905, United States

Contact

Contact Phone: •••-•••-••••
Woodland Memorial Hospital
RECRUITING

Woodland, California, 95695, United States

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

ADVANCED ENDOMETRIAL CARCINOMA ADVANCED ENDOMETRIAL CARCINOMA RECURRENT ENDOMETRIAL CARCINOMA