New drug duo takes on standard chemo in major uterine cancer trial

NCT ID NCT03884101

Summary

This large, completed Phase 3 trial compared a new two-drug combination (pembrolizumab and lenvatinib) against standard chemotherapy for women with advanced or recurrent endometrial (uterine) cancer. The main goal was to see if the drug combination could help patients live longer without their cancer getting worse, and to improve overall survival. Participants who finished the main study could continue receiving one or both drugs in a follow-up extension study.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A.C. Camargo Cancer Center ( Site 2705)

    São Paulo, 01509-900, Brazil

  • AZ Delta ( Site 3206)

    Roeselare, West-Vlaanderen, 8800, Belgium

  • AZ Maria Middelares Gent ( Site 3202)

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Akdeniz Universitesi Tıp Fakultesi ( Site 1301)

    Antalya, 07070, Turkey (Türkiye)

  • Anhui Provincial Cancer Hospital ( Site 2509)

    Hefei, Anhui, 230001, China

  • Arizona Oncology Associates PC- HOPE ( Site 8005)

    Tucson, Arizona, 85711, United States

  • Asan Medical Center ( Site 1800)

    Seoul, 05505, South Korea

  • Azienda Ospedaliera per l Emergenza Cannizzaro ( Site 0807)

    Catania, 95126, Italy

  • BC Cancer-Kelowna - Sindi Ahluwalia Hawkins Centre ( Site 0402)

    Kelowna, British Columbia, V1Y 5L3, Canada

  • BC Cancer-Vancouver Center ( Site 0412)

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Baskent Universitesi Adana Uygulama ve Arastirma Hastanesi ( Site 1303)

    Adana, 01120, Turkey (Türkiye)

  • Baskent Universitesi Ankara Hastanesi ( Site 1300)

    Ankara, 06490, Turkey (Türkiye)

  • Beijing Cancer Hospital ( Site 2504)

    Beijing, Beijing Municipality, 100142, China

  • Beijing Obstetrics and Gynecology Hospital Capital Medical University ( Site 2505)

    Beijing, Beijing Municipality, 100032, China

  • Bialostockie Centrum Onkologii ( Site 1005)

    Bialystok, Podlaskie Voivodeship, 15-027, Poland

  • CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 0414)

    Montreal, Quebec, H1T 2M4, Canada

  • CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0417)

    Sherbrooke, Quebec, J1H 5N4, Canada

  • Caritas-Krankenhaus St. Josef Regensburg ( Site 0613)

    Regensburg, Bavaria, 93053, Germany

  • Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0411)

    Montreal, Quebec, H2X 3E4, Canada

  • Centro Estatal de Cancerologia de Chihuahua ( Site 3101)

    Chihuahua City, 31000, Mexico

  • Centro Oncologico Internacional. SEDNA ( Site 3106)

    Mexico City, 04700, Mexico

  • Centro Oncologico Riojano Integral ( Site 2605)

    La Rioja, 5300, Argentina

  • Centro de Investigacion Clinica Gramel ( Site 3107)

    Mexico City, 03720, Mexico

  • Centrum Onkologii Instytut im. MSC Oddział w Gliwicach ( Site 1017)

    Gliwice, Silesian Voivodeship, 44-102, Poland

  • Chaim Sheba Medical Center ( Site 0707)

    Ramat Gan, 5262000, Israel

  • Charite Universitaetsmedizin Berlin ( Site 0609)

    Berlin, 13353, Germany

  • China Medical University Hospital ( Site 1903)

    Taichung, 404, Taiwan

  • Chongqing Cancer Hospital ( Site 2513)

    Chongqing, Chongqing Municipality, 400030, China

  • Chris OBrien Lifehouse ( Site 1605)

    Camperdown, New South Wales, 2050, Australia

  • Churchill Hospital ( Site 1406)

    Oxford, Oxfordshire, OX3 7LE, United Kingdom

  • City Clinical Hosp.4 of DCC ( Site 1501)

    Dnipro, Dnipropetrovsk Oblast, 49102, Ukraine

  • Clinica de Pesquisas e Ctro de Estudos Onc. Ginecol. e Mamaria Ltda ( Site 2706)

    São Paulo, 01317-001, Brazil

  • Clinical oncology dispensary of Dnipro ( Site 1512)

    Dnipro, Dnipropetrovsk Oblast, 49055, Ukraine

  • Cliniques Universitaires Saint-Luc ( Site 3203)

    Brussels, Bruxelles-Capitale, Region de, 1200, Belgium

  • Communal non profit enterprise Regional Clinical Oncology Center ( Site 1509)

    Kharkiv, Kharkivs’ka Oblast’, 61070, Ukraine

  • Complejo Hospitalario Universitario A Coruna. CHUAC ( Site 1202)

    A Coruña, La Coruna, 15006, Spain

  • Consultorio Dentro de la Torre Medica Dalinde Oncologia Medica ( Site 3108)

    Mexico City, 06760, Mexico

  • Cork University Hospital ( Site 1400)

    Cork, T12 YE02, Ireland

  • Cross Cancer Institute ( Site 0408)

    Edmonton, Alberta, T6G 1Z2, Canada

  • Cukurova Uni. Tip Fakultesi ( Site 1302)

    Adana, 01330, Turkey (Türkiye)

  • Edith Wolfson Medical Center ( Site 0703)

    Holon, Tell Abib, 5822012, Israel

  • Ehime University Hospital ( Site 2413)

    Tōon, Ehime, 791-0295, Japan

  • Epworth Freemasons Hospital ( Site 1609)

    Melbourne, Victoria, 3002, Australia

  • FSBI-FRCC of Special Types Med. Care and Technologies FMBA of Russia ( Site 1102)

    Moscow, Moscow, 115682, Russia

  • Faculdade de Medicina da Universidade Federal de Minas Gerais ( Site 2708)

    Belo Horizonte, Minas Gerais, 30130-100, Brazil

  • Fudan University Shanghai Cancer Center ( Site 2500)

    Shanghai, Shanghai Municipality, 200032, China

  • Gazi Universitesi Tip Fakultesi ( Site 1308)

    Ankara, 05600, Turkey (Türkiye)

  • Georgia Cancer Center at Augusta University ( Site 0222)

    Augusta, Georgia, 30912, United States

  • Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 1511)

    Kharkiv, Kharkivs’ka Oblast’, 61024, Ukraine

  • Guang Xi Tumour Hospital, Department of Chemotherapy ( Site 2517)

    Nanning, Guangxi, 530021, China

  • Gunma Prefectural Cancer Center ( Site 2404)

    Ōta, Gunma, 373-8550, Japan

  • HELIOS Dr. Horst Schmidt Kliniken Wiesbaden ( Site 0623)

    Wiesbaden, Hesse, 65199, Germany

  • Holy Name Medical Center ( Site 0235)

    Teaneck, New Jersey, 07666, United States

  • Hospital Aleman ( Site 2600)

    Buenos Aires, C1118AAT, Argentina

  • Hospital Araujo Jorge Associacao de Combate ao Cancer de Goias ( Site 2702)

    Goiânia, Goiás, 74605-070, Brazil

  • Hospital Clinico San Carlos ( Site 1209)

    Madrid, 28040, Spain

  • Hospital General Universitario de Valencia ( Site 1203)

    Valencia, Valenciana, Comunitat, 46014, Spain

  • Hospital Italiano de Buenos Aires ( Site 2603)

    Buenos Aires, C1199ABB, Argentina

  • Hospital Italiano de La Plata ( Site 2601)

    La Plata, Buenos Aires, B1900AXI, Argentina

  • Hospital Materno Infantil [Malaga, Spain] ( Site 1208)

    Málaga, 29011, Spain

  • Hospital San Lucas Cardiologica del Sureste ( Site 3103)

    Tuxtla Gutiérrez, Chiapas, 29090, Mexico

  • Hospital Universitario Reina Sofia ( Site 1207)

    Córdoba, 14004, Spain

  • Hospital de Base de Sao Jose de Rio Preto ( Site 2704)

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital de Caridade de Ijui ( Site 2712)

    Ijuí, Rio Grande do Sul, 98700-000, Brazil

  • Hubei Cancer Hospital ( Site 2510)

    Wuhan, Hubei, 430079, China

  • Hyogo Cancer Center ( Site 2414)

    Akashi, Hyōgo, 673-8558, Japan

  • I CAN Oncology SA de SV ( Site 3102)

    Monterrey, Nuevo León, 64710, Mexico

  • IDIM Instituto de Diagnostico e Investigaciones Metabolicas ( Site 2607)

    Caba, Buenos Aires, C1012AAR, Argentina

  • IRCCS Giovanni Paolo II. Ospedale Oncologico ( Site 0801)

    Bari, 70124, Italy

  • Institut Catala d Oncologia Badalona ( Site 1201)

    Badalona, Barcelona, 08916, Spain

  • Instituto Nacional do Cancer II ( Site 2707)

    Rio de Janeiro, 20220-410, Brazil

  • Instituto Valenciano de Oncologia - IVO ( Site 1205)

    Valencia, Valenciana, Comunitat, 46009, Spain

  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 2606)

    Mar del Plata, Buenos Aires, B7600FZO, Argentina

  • Instituto do Cancer do Ceara ( Site 2703)

    Fortaleza, Ceará, 60430-230, Brazil

  • Instytut Centrum Zdrowia Matki Polki ( Site 1020)

    Lodz, Łódź Voivodeship, 93-338, Poland

  • Istituto Nazionale Tumori Fondazione Pascale ( Site 0808)

    Naples, 80131, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0800)

    Meldola, Emilia-Romagna, 47014, Italy

  • John Theurer Cancer Center at Hackensack University Med Ctr ( Site 0226)

    Hackensack, New Jersey, 07601, United States

  • Juravinski Cancer Centre ( Site 0406)

    Hamilton, Ontario, L8V 1C3, Canada

  • Keio University Hospital ( Site 2411)

    Tokyo, 160-8582, Japan

  • Khmelnitskiy Regional Onkology Dispensary ( Site 1513)

    Khmelnitskiy, Khmelnytskyi Oblast, 29009, Ukraine

  • Kingston Health Sciences Centre ( Site 0401)

    Kingston, Ontario, K7L 2V7, Canada

  • Krasnoyarsk Regional Clinical oncology dispensary ( Site 1118)

    Krasnoyarsk, Krasnoyarsk Krai, 660133, Russia

  • Kurume University Hospital ( Site 2403)

    Kurume, Fukuoka, 830-0011, Japan

  • Kyiv City Clinical Oncology Centre ( Site 1505)

    Kyiv, 03115, Ukraine

  • Kyorin University Hospital ( Site 2402)

    Mitaka, Tokyo, 181-8611, Japan

  • Legacy Salmon Creek Medical Center ( Site 0253)

    Vancouver, Washington, 98686, United States

  • Linkou Chang Gung Memorial Hospital ( Site 1901)

    Taoyuan District, 333, Taiwan

  • MI Odessa Regional Oncological Centre ( Site 1504)

    Odesa, Odesa Oblast, 65055, Ukraine

  • MI Precarpathian Clinical Oncology Center ( Site 1503)

    Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine

  • MSKCC-Bergen ( Site 0276)

    Montvale, New Jersey, 07645, United States

  • Maine Medical Partners ( Site 0217)

    Scarborough, Maine, 04074, United States

  • Mater Misericordiae Ltd ( Site 1608)

    South Brisbane, Queensland, 4101, Australia

  • McGill University Health Centre ( Site 0404)

    Montreal, Quebec, H4A 3J1, Canada

  • Medical Center Asklepion LLC ( Site 1514)

    Khodosovka, Kyivska Oblast, 08173, Ukraine

  • Medical Oncology Ospedale San Donato ( Site 0812)

    Arezzo, 52100, Italy

  • Medical Rehabilitation Center ( Site 1101)

    Moscow, Moscow, 125367, Russia

  • Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 1507)

    Kyiv, Kyivska Oblast, 03126, Ukraine

  • Medizinische Universitat Innsbruck ( Site 3302)

    Innsbruck, Tyrol, 6020, Austria

  • Medizinische Universitat Wien ( Site 3300)

    Vienna, Vienna, 1090, Austria

  • Meir Medical Center ( Site 0702)

    Kfar Saba, Central District, 4428132, Israel

  • Memorial Sloan Kettering Cancer Center ( Site 0246)

    New York, New York, 10022, United States

  • Memorial Sloan Kettering Cancer Center - Nassau ( Site 0275)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Cancer Center - West Harrison ( Site 0274)

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering Cancer Center- Monmouth ( Site 0273)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan-Kettering Cancer Center At Basking Ridge ( Site 0268)

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan-Kettering Cancer Center at Commack ( Site 0267)

    Commack, New York, 11725, United States

  • Minnesota Oncology Hematology, PA ( Site 8003)

    Minneapolis, Minnesota, 55404, United States

  • Monash Health ( Site 1606)

    Clayton, Victoria, 3168, Australia

  • Mount Vernon Cancer Centre ( Site 1409)

    Northwood, London, City of, HA6 2RN, United Kingdom

  • Nanjing Maternity and Child Health Care Hospital ( Site 2508)

    Nanjing, Jiangsu, 210011, China

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 1009)

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Institute of the MoH of Ukraine ( Site 1510)

    Kyiv, Kyivska Oblast, 03022, Ukraine

  • National Defense Medical College Hospital ( Site 2418)

    Tokorozawa, Saitama, 359-8513, Japan

  • National Hospital Organization Hokkaido Cancer Center ( Site 2408)

    Sapporo, Hokkaido, 003-0804, Japan

  • National Hospital Organization Kyushu Cancer Center ( Site 2405)

    Fukuoka, 811-1395, Japan

  • National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1103)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • National Taiwan University Hospital ( Site 1904)

    Taipei, 10002, Taiwan

  • Niigata Cancer Center Hospital ( Site 2415)

    Niigata, 951-8566, Japan

  • Nippon Medical School Musashi Kosugi Hospital ( Site 2417)

    Kawasaki, Kanagawa, 211-8533, Japan

  • Northern Centre for Cancer Care ( Site 1408)

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Obstetrics and Gynecology Hosp. Fudan University ( Site 2503)

    Shanghai, Shanghai Municipality, 200090, China

  • Osaka International Cancer Institute ( Site 2409)

    Osaka, 541-8567, Japan

  • Ospedale Antonio Perrino ( Site 0806)

    Brindisi, 72100, Italy

  • Ospedale Policlinico S. Orsola-Malpighi ( Site 0803)

    Bologna, 40138, Italy

  • Ospedale dell Angelo ( Site 0810)

    Mestre, Venezia, 30174, Italy

  • Parc de Salut Mar ( Site 1200)

    Barcelona, 08003, Spain

  • Parkland Health & Hospital System ( Site 0272)

    Dallas, Texas, 75235, United States

  • Peking Union Medical College Hospital ( Site 2501)

    Beijing, Beijing Municipality, 100032, China

  • Policlinico Universitario Agostino Gemelli ( Site 0805)

    Rome, Roma, 00168, Italy

  • Prince of Wales Hospital [Australia] ( Site 1603)

    Randwick, New South Wales, 2031, Australia

  • Princess Margaret Cancer Centre ( Site 0409)

    Toronto, Ontario, M5G 2M9, Canada

  • Railway Hospital of OJSC ( Site 1122)

    Saint Petersburg, Sankt-Peterburg, 195271, Russia

  • Rambam Medical Center ( Site 0700)

    Haifa, 3525408, Israel

  • Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 2713)

    São Paulo, 01321-001, Brazil

  • Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1108)

    Kazan', Tatarstan, Respublika, 420029, Russia

  • Roger Maris Cancer Center ( Site 0277)

    Fargo, North Dakota, 58102, United States

  • Royal North Shore Hospital ( Site 1600)

    St Leonards, New South Wales, 2065, Australia

  • Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1100)

    Moscow, Moscow, 115478, Russia

  • SPb SBHI City Clinical Oncological Dispensary ( Site 1104)

    Saint Petersburg, Sankt-Peterburg, 198255, Russia

  • Saitama Cancer Center ( Site 2406)

    Kitaadachi-gun, Saitama, 362-0806, Japan

  • Saitama Medical University International Medical Center ( Site 2410)

    Hidaka, Saitama, 350-1298, Japan

  • Samara Regional Clinical Oncology Center ( Site 1117)

    Samara, Samara Oblast, 443031, Russia

  • Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie ( Site 1008)

    Lublin, Lower Silesian Voivodeship, 20-081, Poland

  • Samsung Medical Center ( Site 1803)

    Seoul, 06351, South Korea

  • Sanford Cancer Center Oncology Clinic ( Site 0205)

    Sioux Falls, South Dakota, 57104, United States

  • Seoul National University Bundang Hospital ( Site 1802)

    Seongnam-si, Kyonggi-do, 13620, South Korea

  • Seoul National University Hospital ( Site 1801)

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System ( Site 1804)

    Seoul, 03722, South Korea

  • Showa University Hospital ( Site 2419)

    Tokyo, 142-8666, Japan

  • Siberian State Medical University ( Site 1121)

    Tomsk, Tomsk Oblast, 634028, Russia

  • Sir Charles Gairdner Hospital ( Site 1604)

    Nedlands, Western Australia, 6009, Australia

  • Smilow Cancer Hospital at Yale New Haven ( Site 0202)

    New Haven, Connecticut, 06511, United States

  • St James Hospital ( Site 1401)

    Dublin, Dublin 8, Ireland

  • St. Marianna University School of Medicine Hospital ( Site 2416)

    Kawasaki, Kanagawa, 216-8511, Japan

  • St.Petersburg Clinical Hospital RAS ( Site 1124)

    Saint Petersburg, Sankt-Peterburg, 194017, Russia

  • Sunnybrook Research Institute ( Site 0410)

    Toronto, Ontario, M4N 3M5, Canada

  • Szpital Kliniczny im Ks Anny Mazowieckiej ( Site 1011)

    Warsaw, Masovian Voivodeship, 00-315, Poland

  • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie ( Site 1019)

    Krakow, Lesser Poland Voivodeship, 31-826, Poland

  • Taichung Veterans General Hospital ( Site 1902)

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital ( Site 1900)

    Taipei, 11217, Taiwan

  • Texas Oncology-The Woodlands ( Site 8000)

    The Woodlands, Texas, 77380, United States

  • The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0206)

    New York, New York, 10011, United States

  • The Cancer Institute Hospital of JFCR ( Site 2401)

    Tokyo, 135-8550, Japan

  • The Credit Valley Hospital ( Site 0403)

    Mississauga, Ontario, L5M 2N1, Canada

  • The Crown Princess Mary Cancer Centre - Westmead Hospital ( Site 1602)

    Westmead, New South Wales, 2145, Australia

  • The First Affiliated Hospital of Xinjiang Medical University ( Site 2515)

    Ürümqi, Xinjiang, 830054, China

  • The First Affiliated Hospital.Sun Yat-sen University ( Site 2507)

    Guangzhou, Guangdong, 510080, China

  • The James Cook University Hospital ( Site 1403)

    Middlesbrough, TS4 3BW, United Kingdom

  • The first affiliated Hospital of Xi an Jiaotong University ( Site 2502)

    Xi'an, Shaanxi, 710061, China

  • UCLA Hematology and Oncology Clinic (Westwood) ( Site 0233)

    Los Angeles, California, 90095, United States

  • UCLH NHS Foundation Trust ( Site 1405)

    London, London, City of, NW1 2PG, United Kingdom

  • UZ Leuven ( Site 3200)

    Leuven, Antwerpen, 3000, Belgium

  • UZA University Hospital Antwerp ( Site 3204)

    Edegem, Antwerpen, 2650, Belgium

  • Uludag Universitesi Tip Fakultesi ( Site 1307)

    Bursa, 16059, Turkey (Türkiye)

  • Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da Pucrs ( Site 2701)

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Universitaetsklinikum Essen ( Site 0616)

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitaetsklinikum Jena ( Site 0612)

    Jena, Thuringia, 07747, Germany

  • Universitaetsklinikum Muenster ( Site 0615)

    Münster, Baden-Wurttemberg, 48149, Germany

  • Universitaetsmedizin Mannheim. Klinik fuer Kinder und Jugendmedizin ( Site 0622)

    Mannheim, Baden-Wurttemberg, 68167, Germany

  • Universitatsklinik fuer Frauenheilkunde und Geburtshilfe ( Site 3301)

    Graz, Styria, 8036, Austria

  • University of Colorado Cancer Center ( Site 0204)

    Aurora, Colorado, 80045, United States

  • University of Miami Health System ( Site 0249)

    Miami, Florida, 33136, United States

  • University of North Carolina- Chapel Hill ( Site 0254)

    Chapel Hill, North Carolina, 27599, United States

  • University of Rochester ( Site 0238)

    Rochester, New York, 14642, United States

  • University of South Alabama, Mitchell Cancer Institute ( Site 0245)

    Mobile, Alabama, 36604, United States

  • University of Texas Southwestern Medical Center ( Site 0264)

    Dallas, Texas, 75390-9015, United States

  • University of the Ryukyus Hospital ( Site 2412)

    Nakagami-gun, Okinawa, 903-0215, Japan

  • Western General Hospital ( Site 1411)

    Edinburgh, Edinburgh, City of, EH4 2XU, United Kingdom

  • Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 1004)

    Poznan, Greater Poland Voivodeship, 61-866, Poland

  • Willamette Valley Cancer Institute and Research Center ( Site 8004)

    Eugene, Oregon, 97401, United States

  • Women s Hospital School of Medicine Zhejiang University ( Site 2511)

    Hangzhou, Zhejiang, 310006, China

  • Women's Cancer Care ( Site 0208)

    Covington, Louisiana, 70433, United States

  • Xiangya Hospital Central-South University ( Site 2512)

    Changsha, Hunan, 410008, China

  • Zhejiang Cancer Hospital ( Site 2506)

    Hangzhou, Zhejiang, 310022, China

Conditions

Explore the condition pages connected to this study.