New hope for melanoma brain metastases: Two-Step treatment trial launches
NCT ID NCT06887088
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing a two-step treatment for people with BRAF-mutated melanoma that has spread to the brain and is causing symptoms. First, participants take two targeted pills (encorafenib and binimetinib) for about two months. Then, they receive two immunotherapy drugs (cemiplimab and fianlimab) intravenously every three weeks for up to two years. The goal is to see if this approach can keep brain tumors from growing for at least six months in more patients than historical treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- encorafenib, binimetinib, cemiplimab, and fianlimab
- What this could lead to
- If successful, this could offer a new treatment option for people with BRAF-mutated melanoma that has spread to the brain and is causing symptoms.
- What could go wrong
- This is a small, early-phase trial with only 33 participants and no comparison group. The treatment may not work better than existing options, and side effects from the drug combination could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinico Universitario Virgen de la Arrixaca
RECRUITINGMurcia, Murcia, 30120, Spain
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Complejo Hospitalario Universitario A Coruña
RECRUITINGA Coruña, A Coruña, 15006, Spain
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Hospital Clinico San Carlos
RECRUITINGMadrid, Madrid, 28040, Spain
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Hospital Clínic de Barcelona
RECRUITINGBarcelona, Barcelona, 08036, Spain
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Hospital Clínico Universitario Valencia.
RECRUITINGValencia, Valencia, 46010, Spain
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Hospital General Universitario de Valencia
RECRUITINGValencia, Valencia, 46014, Spain
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Hospital Regional Universitario de Málaga
RECRUITINGMálaga, Málaga, 29010, Spain
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Hospital Universitario Gregorio Marañon
NOT_YET_RECRUITINGMadrid, Madrid, 28007, Spain
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Hospital Universitario Marqués de Valdecilla
RECRUITINGSantander, Cantabria, 39008, Spain
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Hospital Universitario Puerta del Hierro
RECRUITINGMajadahonda, Madrid, 28222, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Madrid, 28034, Spain
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Hospital Universitario San Pedro de Alcántara
RECRUITINGCáceres, Cáceres, 10003, Spain
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Hospital Universitario Vall d´Hebron
RECRUITINGBarcelona, Barcelona, 08035, Spain
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Hospital Universitario de Burgos
RECRUITINGBurgos, Burgos, 09006, Spain
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Hospital Virgen de la Macarena (Sevilla)
RECRUITINGSeville, Sevilla, 41009, Spain
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Instituto Catalán de Oncología - Hospital Duran i Reynals
RECRUITINGBarcelona, Barcelona, 08908, Spain
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Onkologikoa (Donostia)
RECRUITINGDonostia / San Sebastian, Donostia, 20014, Spain
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Quiron Dexeus - IOR
RECRUITINGBarcelona, Barcelona, 08028, Spain
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