New shot could ease pain of rare foot condition

NCT ID NCT06151197

Ongoing Symptom relief Sponsor: Endo USA Inc., a Keenova Therapeutics Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tests an injection called EN3835 against a placebo for people with Ledderhose disease, which causes painful lumps on the soles of the feet. About 418 adults with foot pain from this condition will receive either the drug or a placebo. The main goal is to see if EN3835 reduces daily foot pain and improves function over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

EN3835 (a biologic injection)

What this could lead to

If it works, this could provide a non-surgical treatment option to reduce foot pain and improve daily function for people with Ledderhose disease.

What could go wrong

This is a late-stage trial, but the treatment may not work better than placebo. Possible injection-site reactions or lack of long-term benefit are risks.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Fibromatosis, Plantar plantar fibromatosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEDDERHOSE DISEASE PLANTAR FIBROMATOSIS

Contacts and locations

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Locations

Endo Clinical Site 1

Pinellas Park, Florida, 33782, United States
Endo Clinical Site 2

Encinitas, California, 92024, United States
Endo Site 10

Altoona, Pennsylvania, 16602, United States
Endo Site 11

Tucson, Arizona, 85712, United States
Endo Site 12

Jefferson City, Missouri, 65109, United States
Endo Site 13

Suffolk, Virginia, 23434, United States
Endo Site 14

Plantation, Florida, 33317, United States
Endo Site 15

Durham, North Carolina, 27704, United States
Endo Site 16

Grand Rapids, Michigan, 49525, United States
Endo Site 17

Westminster, Colorado, 80031, United States
Endo Site 18

San Antonio, Texas, 78251, United States
Endo Site 19

Palm Beach Gardens, Florida, 33410, United States
Endo Site 20

Wilmington, North Carolina, 28412, United States
Endo Site 21

Miami, Florida, 33184, United States
Endo Site 22

Hialeah, Florida, 33013, United States
Endo Site 23

Miami, Florida, 33126, United States
Endo Site 24

Lawrenceville, Georgia, 30043, United States
Endo Site 25

Dallas, Texas, 75208, United States
Endo Site 26

Miami, Florida, 33156, United States
Endo Site 27

O'Fallon, Illinois, 62269, United States
Endo Site 28

Lancaster, California, 93534, United States
Endo Site 29

Sherman Oaks, California, 91403, United States
Endo Site 3

Bedford, Texas, 76021, United States
Endo Site 30

Tarzana, California, 91356, United States
Endo Site 31

Corona, California, 92882, United States
Endo Site 33

Virginia Gardens, Florida, 33166, United States
Endo Site 34

Oradell, New Jersey, 07649, United States
Endo Site 35

North Miami Beach, Florida, 33169, United States
Endo Site 36

Missoula, Montana, 59804, United States
Endo Site 37

San Antonio, Texas, 78258, United States
Endo Site 38

State College, Pennsylvania, 16801, United States
Endo Site 39

Cerritos, California, 90703, United States
Endo Site 4

McAllen, Texas, 78501, United States
Endo Site 40

Humble, Texas, 77338, United States
Endo Site 41

Bountiful, Utah, 84010, United States
Endo Site 42

Mesa, Arizona, 85210, United States
Endo Site 43

Burleson, Texas, 76028, United States
Endo Site 44

Malvern, Pennsylvania, 19355, United States
Endo Site 45

Oak Brook, Illinois, 60523, United States
Endo Site 46

San Antonio, Texas, 78224, United States
Endo Site 47

Johnstown, Colorado, 80534, United States
Endo Site 48

Arlington, Texas, 76015, United States
Endo Site 49

Castro Valley, California, 94546, United States
Endo Site 5

Pasadena, Maryland, 21122, United States
Endo Site 50

San Francisco, California, 94115, United States
Endo Site 51

Billings, Montana, 59101, United States
Endo Site 52

Falls Church, Virginia, 22042, United States
Endo Site 53

Los Angeles, California, 90063, United States
Endo Site 54

Overland Park, Kansas, 66211, United States
Endo Site 55

Houston, Texas, 77027, United States
Endo Site 56

Shreveport, Louisiana, 71101, United States
Endo Site 59

Jacksonville, Florida, 32209, United States
Endo Site 6

Salt Lake City, Utah, 84107, United States
Endo Site 60

Sweetwater, Florida, 33172, United States
Endo Site 61

Torrance, California, 90502, United States
Endo Site 62

Vineland, New Jersey, 08360, United States
Endo Site 63

Oklahoma City, Oklahoma, 73102, United States
Endo Site 64

Scottsdale, Arizona, 85260, United States
Endo Site 65

Parker, Colorado, 80134, United States
Endo Site 68

Mayagüez, 00682, Puerto Rico
Endo Site 69

Ponce, 00716, Puerto Rico
Endo Site 7

Georgetown, Texas, 78628, United States
Endo Site 70

Mayagüez, 00680, Puerto Rico
Endo Site 8

Fresno, California, 93710, United States
Endo Site 9

Los Angeles, California, 90010, United States
Endo Site32

Fort Worth, Texas, 76104, United States