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Two talking therapies go Head-to-Head for trauma and depression

NCT ID NCT04021329

Symptom relief Sponsor: Khushal Khan Khattak Univeristy, Karak, Pakistan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers in Pakistan are comparing two psychological treatments, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), for people with post-traumatic stress disorder (PTSD) and major depression. The trial enrolls 100 adults aged 18 to 60 at two rehabilitation centers. Participants receive one of the therapies, and researchers measure changes in PTSD and depression symptoms at baseline, during treatment, after treatment, and six months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Eye Movement Desensitization and Reprocessing (EMDR) therapy and Cognitive Behavioral Therapy (CBT)
What this could lead to
If one therapy proves more effective, it could guide treatment choices for PTSD and depression in Pakistan and similar settings.
What could go wrong
This is a small trial at two rehabilitation centers, so results may not apply broadly. Both therapies are well established, but individual responses vary and some people may not improve.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Oct 2020

Finished

Oct 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Exclusion Criteria: The following patients will be excluded: 1. Patients below the age of 18 years and above 60 years as this study is not on children or older patients; 2. Patients who can't move their hands and eyes/or can't perform basic movements; 3. Patients who are unconscious for longer periods and unable to recover consciousness; 4. Patients not meeting the basic screening criteria of PTSD/ PTSD is not the main problem; 5. Patients with severe intellectual impairments, since such patients are difficult to communicate.

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Conditions

The condition(s) this trial relates to.

major depressive disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Efficacy of psychotherapy

Contacts and locations

Locations

  • Anwar Khan

    Karak, KPK, 27200, Pakistan