New drug efruxifermin aims to reverse liver scarring in NASH patients

NCT ID NCT06161571

Ongoing Disease control Sponsor: Akero Therapeutics, Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 study tests whether efruxifermin, given as a weekly shot, is safe and can improve liver health in 700 adults with NASH/MASH (a type of fatty liver disease). Participants receive either the drug or a placebo. The study tracks side effects and measures changes in liver stiffness and fibrosis scores. Results could lead to a new treatment option for this common liver condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Efruxifermin (a drug given as a shot under the skin)
What this could lead to: If successful, efruxifermin could become a new treatment option to reduce liver scarring and improve liver health in people with NASH/MASH.
What could go wrong: This is a Phase 3 trial, but results are not yet available. The drug may not prove effective or could have side effects. It is also tested in a specific group, so benefits may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAFLD/MASLD NASH/MASH

Contacts and locations

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Locations

Akero Clinical Study Site

Birmingham, Alabama, 35209, United States
Akero Clinical Study Site

Chandler, Arizona, 85224, United States
Akero Clinical Study Site

Flagstaff, Arizona, 86001, United States
Akero Clinical Study Site

Peoria, Arizona, 85381, United States
Akero Clinical Study Site

Tucson, Arizona, 85712, United States
Akero Clinical Study Site

Tucson, Arizona, 85715, United States
Akero Clinical Study Site

Conway, Arkansas, 72032, United States
Akero Clinical Study Site

Jonesboro, Arkansas, 72401, United States
Akero Clinical Study Site

Little Rock, Arkansas, 72205, United States
Akero Clinical Study Site

North Little Rock, Arkansas, 72117, United States
Akero Clinical Study Site

Chula Vista, California, 91910, United States
Akero Clinical Study Site

Coronado, California, 92118, United States
Akero Clinical Study Site

Cypress, California, 90630, United States
Akero Clinical Study Site

Inglewood, California, 90301, United States
Akero Clinical Study Site

La Mesa, California, 91942, United States
Akero Clinical Study Site

Lancaster, California, 93534, United States
Akero Clinical Study Site

Los Angeles, California, 90036-4669, United States
Akero Clinical Study Site

Los Angeles, California, 90057, United States
Akero Clinical Study Site

Palm Springs, California, 92262, United States
Akero Clinical Study Site

San Diego, California, 92120, United States
Akero Clinical Study Site

San Diego, California, 92123, United States
Akero Clinical Study Site

San Francisco, California, 94115, United States
Akero Clinical Study Site

Santa Maria, California, 93458, United States
Akero Clinical Study Site

Englewood, Colorado, 80113, United States
Akero Clinical Study Site

Bradenton, Florida, 34208, United States
Akero Clinical Study Site

Brandon, Florida, 33511, United States
Akero Clinical Study Site

Fort Myers, Florida, 33912, United States
Akero Clinical Study Site

Gainesville, Florida, 32610, United States
Akero Clinical Study Site

Hialeah Gardens, Florida, 33016, United States
Akero Clinical Study Site

Inverness, Florida, 34452, United States
Akero Clinical Study Site

Jacksonville, Florida, 32256, United States
Akero Clinical Study Site

Lady Lake, Florida, 32159, United States
Akero Clinical Study Site

Lakewood Rch, Florida, 34211, United States
Akero Clinical Study Site

Largo, Florida, 33777, United States
Akero Clinical Study Site

Maitland, Florida, 32751, United States
Akero Clinical Study Site

Miami, Florida, 33136, United States
Akero Clinical Study Site

Miami Lakes, Florida, 33016, United States
Akero Clinical Study Site

Naples, Florida, 34102, United States
Akero Clinical Study Site

Ocala, Florida, 34471, United States
Akero Clinical Study Site

Port Orange, Florida, 32127, United States
Akero Clinical Study Site

Sarasota, Florida, 34240, United States
Akero Clinical Study Site

The Villages, Florida, 32162, United States
Akero Clinical Study Site

Venice, Florida, 34285, United States
Akero Clinical Study Site

Viera, Florida, 32940, United States
Akero Clinical Study Site

West Palm Beach, Florida, 33401, United States
Akero Clinical Study Site

Winter Park, Florida, 32789, United States
Akero Clinical Study Site

Winter Park, Florida, 32792, United States
Akero Clinical Study Site

Columbus, Georgia, 31904, United States
Akero Clinical Study Site

Gainesville, Georgia, 30501, United States
Akero Clinical Study Site

Marietta, Georgia, 30060, United States
Akero Clinical Study Site

South Bend, Indiana, 46635, United States
Akero Clinical Study Site

West Des Moines, Iowa, 50265, United States
Akero Clinical Study Site

Topeka, Kansas, 66606, United States
Akero Clinical Study Site

Wichita, Kansas, 67205, United States
Akero Clinical Study Site

Bastrop, Louisiana, 71220, United States
Akero Clinical Study Site

Covington, Louisiana, 70433, United States
Akero Clinical Study Site

Houma, Louisiana, 70363, United States
Akero Clinical Study Site

Marrero, Louisiana, 70072, United States
Akero Clinical Study Site

Metairie, Louisiana, 70006, United States
Akero Clinical Study Site

New Orleans, Louisiana, 70121, United States
Akero Clinical Study Site

Shreveport, Louisiana, 71103, United States
Akero Clinical Study Site

Baltimore, Maryland, 21202, United States
Akero Clinical Study Site

Glen Burnie, Maryland, 21061, United States
Akero Clinical Study Site

Greenbelt, Maryland, 20770, United States
Akero Clinical Study Site

South Dartmouth, Massachusetts, 02747, United States
Akero Clinical Study Site

Southfield, Michigan, 48075, United States
Akero Clinical Study Site

Wyoming, Michigan, 49519, United States
Akero Clinical Study Site

Ypsilanti, Michigan, 48197, United States
Akero Clinical Study Site

Columbia, Missouri, 65201, United States
Akero Clinical Study Site

Kansas City, Missouri, 64131, United States
Akero Clinical Study Site

Las Vegas, Nevada, 89106, United States
Akero Clinical Study Site

Las Vegas, Nevada, 89109, United States
Akero Clinical Study Site

Reno, Nevada, 89511, United States
Akero Clinical Study Site

Brick, New Jersey, 08724, United States
Akero Clinical Study Site

Florham Park, New Jersey, 07932, United States
Akero Clinical Study Site

Somers Point, New Jersey, 08244, United States
Akero Clinical Study Site

Sparta, New Jersey, 07871, United States
Akero Clinical Study Site

Santa Fe, New Mexico, 87505, United States
Akero Clinical Study Site

New York, New York, 10029, United States
Akero Clinical Study Site

New York, New York, 10033, United States
Akero Clinical Study Site

Chapel Hill, North Carolina, 27516, United States
Akero Clinical Study Site

Charlotte, North Carolina, 28204, United States
Akero Clinical Study Site

Fayetteville, North Carolina, 28304, United States
Akero Clinical Study Site

Morehead City, North Carolina, 28557, United States
Akero Clinical Study Site

New Bern, North Carolina, 28562, United States
Akero Clinical Study Site

Raleigh, North Carolina, 27612, United States
Akero Clinical Study Site

Statesville, North Carolina, 28625, United States
Akero Clinical Study Site

Columbus, Ohio, 43213, United States
Akero Clinical Study Site

Dayton, Ohio, 45414, United States
Akero Clinical Study Site

Springboro, Ohio, 45066, United States
Akero Clinical Study Site

Westlake, Ohio, 44145, United States
Akero Clinical Study Site

Philadelphia, Pennsylvania, 19104, United States
Akero Clinical Study Site

Philadelphia, Pennsylvania, 19107, United States
Akero Clinical Study Site

Pittsburgh, Pennsylvania, 15213, United States
Akero Clinical Study Site

Columbia, South Carolina, 29204, United States
Akero Clinical Study Site

Summerville, South Carolina, 29485, United States
Akero Clinical Study Site

Chattanooga, Tennessee, 37421, United States
Akero Clinical Study Site

Clarksville, Tennessee, 37040, United States
Akero Clinical Study Site

Hermitage, Tennessee, 37076, United States
Akero Clinical Study Site

Nashville, Tennessee, 37211, United States
Akero Clinical Study Site

Amarillo, Texas, 79106, United States
Akero Clinical Study Site

Austin, Texas, 78745, United States
Akero Clinical Study Site

Austin, Texas, 78757, United States
Akero Clinical Study Site

Bellaire, Texas, 77401, United States
Akero Clinical Study Site

Brownsville, Texas, 78520, United States
Akero Clinical Study Site

Corpus Christi, Texas, 78404, United States
Akero Clinical Study Site

Dallas, Texas, 75203, United States
Akero Clinical Study Site

Dallas, Texas, 75230, United States
Akero Clinical Study Site

Dallas, Texas, 75234, United States
Akero Clinical Study Site

Dallas, Texas, 75390, United States
Akero Clinical Study Site

Edinburg, Texas, 78539, United States
Akero Clinical Study Site

Fort Worth, Texas, 76104, United States
Akero Clinical Study Site

Houston, Texas, 77030, United States
Akero Clinical Study Site

Houston, Texas, 77079, United States
Akero Clinical Study Site

Houston, Texas, 77084, United States
Akero Clinical Study Site

Lewisville, Texas, 75057, United States
Akero Clinical Study Site

McAllen, Texas, 78504, United States
Akero Clinical Study Site

San Antonio, Texas, 78215, United States
Akero Clinical Study Site

San Antonio, Texas, 78222, United States
Akero Clinical Study Site

San Antonio, Texas, 78229, United States
Akero Clinical Study Site

San Antonio, Texas, 78258, United States
Akero Clinical Study Site

San Marcos, Texas, 78666-7502, United States
Akero Clinical Study Site

Waco, Texas, 76710, United States
Akero Clinical Study Site

Webster, Texas, 77598, United States
Akero Clinical Study Site

Wichita Falls, Texas, 76301, United States
Akero Clinical Study Site

Ogden, Utah, 84405, United States
Akero Clinical Study Site

Salt Lake City, Utah, 84117, United States
Akero Clinical Study Site

Sandy City, Utah, 84092, United States
Akero Clinical Study Site

South Ogden, Utah, 84405, United States
Akero Clinical Study Site

Falls Church, Virginia, 22042-3300, United States
Akero Clinical Study Site

Norfolk, Virginia, 23502, United States
Akero Clinical Study Site

Richmond, Virginia, 23226, United States
Akero Clinical Study Site

Richmond, Virginia, 23236, United States
Akero Clinical Study Site

Richmond, Virginia, 23249, United States
Akero Clinical Study Site

Richmond, Virginia, 23298, United States
Akero Clinical Study Site

Roanoke, Virginia, 24014, United States
Akero Clinical Study Site

Suffolk, Virginia, 23435, United States
Akero Clinical Study Site

Seattle, Washington, 98105, United States
Akero Clinical Study Site

Spokane, Washington, 99218, United States
Akero Clinical Study Site

Ramos Mejía, Buenos Aires, B1704ETD, Argentina
Akero Clinical Study Site

Buenos Aires, Distrito Federal, C1125ABE, Argentina
Akero Clinical Study Site

Buenos Aires, C1118AAT, Argentina
Akero Clinical Study Site

Buenos Aires, C1280AEB, Argentina
Akero Clinical Study Site

Broadmeadow, New South Wales, 2292, Australia
Akero Clinical Study Site

Westmead, New South Wales, 2145, Australia
Akero Clinical Study Site

Adelaide, South Australia, 5000, Australia
Akero Clinical Study Site

Clayton, Victoria, 3168, Australia
Akero Clinical Study Site

Epping, Victoria, 3076, Australia
Akero Clinical Study Site

Heidelberg, Victoria, 3084, Australia
Akero Clinical Study Site

Melbourne, Victoria, 3004, Australia
Akero Clinical Study Site

Murdoch, Western Australia, 6150, Australia
Akero Clinical Study Site

Perth, Western Australia, 6000, Australia
Akero Clinical Study Site

Edmonton, Alberta, T6G 2X8, Canada
Akero Clinical Study Site

Hamilton, Ontario, L8S 4K1, Canada
Akero Clinical Study Site

Toronto, Ontario, M6H 3M1, Canada
Akero Clinical Study Site

Vaughan, Ontario, L4L 4Y7, Canada
Akero Clinical Study Site

Terrebonne, Quebec, J7B6B7, Canada
Akero Clinical Study Site

Surat, Gujarat, 395002, India
Akero Clinical Study Site

Vadodara, Gujarat, 390007, India
Akero Clinical Study Site

Thiruvananthapuram, Kerala, 695011, India
Akero Clinical Study Site

Dahegaon, Maharashtra, 441108, India
Akero Clinical Study Site

Mumbai, Maharashtra, 400012, India
Akero Clinical Study Site

Nagpur, Maharashtra, 440010, India
Akero Clinical Study Site

Pune, Maharashtra, 412201, India
Akero Clinical Study Site

New Delhi, National Capital Territory of Delhi, 110029, India
Akero Clinical Study Site

Chandigarh, Punjab, 160012, India
Akero Clinical Study Site

Jaipur, Rajasthan, 302001, India
Akero Clinical Study Site

Coimbatore, Tamil Nadu, 641005, India
Akero Clinical Study Site

Hyderabad, Telangana, 500 004, India
Akero Clinical Study Site

Varanasi, Uttar Pradesh, 221005, India
Akero Clinical Study Site

Kolkata, West Bengal, 700020, India
Akero Clinical Study Site

Kolkata, West Bengal, 700073, India
Akero Clinical Study Site

Kolkata, West Bengal, 700150, India
Akero Clinical Study Site

Petah Tikva, Central District, 4941492, Israel
Akero Clinical Study Site

Ramat Gan, Central District, 5265601, Israel
Akero Clinical Study Site

Haifa, Haifa District, 3109601, Israel
Akero Clinical Study Site

Haifa, Haifa District, 3436212, Israel
Akero Clinical Study Site

Afula, Northern District, 1834111, Israel
Akero Clinical Study Site

Nahariya, Northern District, 22100, Israel
Akero Clinical Study Site

Nazareth, Northern District, 16234, Israel
Akero Clinical Study Site

Jerusalem, 9103102, Israel
Akero Clinical Study Site

Jerusalem, 9112001, Israel
Akero Clinical Study Site

Tel Aviv, 6423906, Israel
Akero Clinical Study Site

Mexico City, Mexico City, 06700, Mexico
Akero Clinical Study Site

Manati, 00674, Puerto Rico
Akero Clinical Study Site

San Juan, 00927, Puerto Rico
Akero Clinical Study Site

Daegu, Daegu Gwang'yeogsi, 41944, South Korea
Akero Clinical Study Site

Goyang-si, Gyeonggi-do, 1232, South Korea
Akero Clinical Study Site

Incheon, Gyeonggi-do, 22332, South Korea
Akero Clinical Study Site

Seongnam-si, Gyeonggi-do, 13496, South Korea
Akero Clinical Study Site

Daegu, Gyeongsangbuk-do, 42601, South Korea
Akero Clinical Study Site

Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 04763, South Korea
Akero Clinical Study Site

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Akero Clinical Study Site

Olten, Canton of Solothurn, 4600, Switzerland
Akero Clinical Study Site

Bern, 3010, Switzerland
Akero Clinical Study Site

Sankt Gallen, 9007, Switzerland
Akero Clinical Study Site

Changhua, Changhua, 500, Taiwan
Akero Clinical Study Site

Taichung, Taichung, 40447, Taiwan
Akero Clinical Study Site

Tainan, Tainan, 73657, Taiwan
Akero Clinical Study Site

Taipei, 10048, Taiwan
Akero Clinical Study Site

Yenimahalle, Ankara, 06500, Turkey (Türkiye)
Akero Clinical Study Site

Bornova, İzmir, 35100, Turkey (Türkiye)
Akero Clinical Study Site

Bursa, 16059, Turkey (Türkiye)
Akero Clinical Study Site

Rize, 53020, Turkey (Türkiye)
Akero Clinical Study Site

Liverpool, England, L9 7AL, United Kingdom
Akero Clinical Study Site

London, England, E1 1BB, United Kingdom
Akero Clinical Study Site

London, England, NW3 2QG, United Kingdom
Akero Clinical Study Site

London, England, SE5 9RS, United Kingdom
Akero Clinical Study Site

London, England, SW10 9NH, United Kingdom
Akero Clinical Study Site

London, England, W2 1NY, United Kingdom
Akero Clinical Study Site

Newcastle upon Tyne, England, NE7 7DN, United Kingdom

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