Major trial tests new drug to halt scarring in fatty liver disease

NCT ID NCT06215716

Recruiting now Disease control Sponsor: Akero Therapeutics, Inc Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether the drug efruxifermin can help people with a serious form of fatty liver disease called NASH or MASH, which causes liver inflammation and scarring. It will enroll 1,650 adults with moderate to advanced liver scarring but not full cirrhosis. The main goals are to see if the drug can resolve the liver inflammation and improve the scarring, while also monitoring for serious liver-related health problems.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Locations

Akero Clinical Study Site
RECRUITING

Birmingham, Alabama, 35209, United States

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Akero Clinical Study Site
RECRUITING

Dothan, Alabama, 36301, United States

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Akero Clinical Study Site
RECRUITING

Chandler, Arizona, 85224, United States

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Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Flagstaff, Arizona, 86001, United States
Akero Clinical Study Site
RECRUITING

Mesa, Arizona, 85213, United States

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Peoria, Arizona, 85381, United States

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Tucson, Arizona, 85712, United States
Akero Clinical Study Site
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Tucson, Arizona, 85712, United States

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Tucson, Arizona, 85713, United States

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RECRUITING

Tucson, Arizona, 85715, United States

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Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Conway, Arkansas, 72032, United States
Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Jonesboro, Arkansas, 72401, United States
Akero Clinical Study Site
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Little Rock, Arkansas, 72205, United States

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RECRUITING

North Little Rock, Arkansas, 72117, United States

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Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Chula Vista, California, 91910, United States
Akero Clinical Study Site
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Coronado, California, 92118, United States

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Escondido, California, 92025, United States

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Folsom, California, 95630, United States

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Inglewood, California, 90301, United States

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ACTIVE_NOT_RECRUITING

La Mesa, California, 91942, United States
Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Lancaster, California, 93534, United States
Akero Clinical Study Site
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Lancaster, California, 93534, United States

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Long Beach, California, 90815, United States

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ACTIVE_NOT_RECRUITING

Los Angeles, California, 90036, United States
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Los Angeles, California, 90048, United States

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Los Angeles, California, 90057, United States

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Newport Beach, California, 92663, United States

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Orange, California, 92868, United States

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Palm Springs, California, 92262, United States

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Pasadena, California, 91105, United States

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Redwood City, California, 94063, United States

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Sacramento, California, 95817, United States

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RECRUITING

San Diego, California, 92120, United States

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ACTIVE_NOT_RECRUITING

San Diego, California, 92123, United States
Akero Clinical Study Site
RECRUITING

San Diego, California, 92161, United States

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San Francisco, California, 94115, United States

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San Francisco, California, 94117, United States

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Santa Maria, California, 93458, United States

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Aurora, Colorado, 80045, United States

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Colorado Springs, Colorado, 80907, United States

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Englewood, Colorado, 80113, United States

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New Haven, Connecticut, 06520, United States

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Washington D.C., District of Columbia, 20007, United States

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Washington D.C., District of Columbia, 20422, United States

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Bradenton, Florida, 34208, United States

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Brandon, Florida, 33511, United States

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Doral, Florida, 33126, United States

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Fort Myers, Florida, 33912, United States

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Gainesville, Florida, 32610, United States

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Hialeah Gardens, Florida, 33016, United States

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Inverness, Florida, 34452, United States

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Jacksonville, Florida, 32256, United States

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Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Lady Lake, Florida, 32159, United States
Akero Clinical Study Site
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Lakewood Rch, Florida, 34211, United States

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Largo, Florida, 33777, United States

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Lehigh Acres, Florida, 33936, United States

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ACTIVE_NOT_RECRUITING

Maitland, Florida, 32751, United States
Akero Clinical Study Site
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Margate, Florida, 33063, United States

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Miami, Florida, 33136, United States

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Miami, Florida, 33175, United States

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Miami Gardens, Florida, 33014, United States

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Miami Lakes, Florida, 33016, United States

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Naples, Florida, 34102, United States

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New Port Richey, Florida, 34653, United States

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Ocala, Florida, 34471, United States

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Orlando, Florida, 32807, United States

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Pembroke Pines, Florida, 33027, United States

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Port Orange, Florida, 32127, United States

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NOT_YET_RECRUITING

Riverview, Florida, 33578, United States

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Sarasota, Florida, 34240, United States

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Temple Terrace, Florida, 33617, United States

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ACTIVE_NOT_RECRUITING

Venice, Florida, 34285, United States
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Viera, Florida, 32940, United States

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ACTIVE_NOT_RECRUITING

West Palm Beach, Florida, 33401, United States
Akero Clinical Study Site
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Weston, Florida, 33331, United States

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Winter Park, Florida, 32789, United States

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Winter Park, Florida, 32792, United States

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Zephyrhills, Florida, 33542, United States

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NOT_YET_RECRUITING

Atlanta, Georgia, 30309, United States

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Columbus, Georgia, 31904, United States

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Gainesville, Georgia, 30501, United States

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Marietta, Georgia, 30060, United States

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Chicago, Illinois, 60637, United States

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Hammond, Indiana, 46324, United States

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Indianapolis, Indiana, 46202, United States

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South Bend, Indiana, 46635, United States

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West Des Moines, Iowa, 50265, United States

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Topeka, Kansas, 66606, United States

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ACTIVE_NOT_RECRUITING

Wichita, Kansas, 67205, United States
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Louisville, Kentucky, 40202, United States

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Bastrop, Louisiana, 71220, United States

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Covington, Louisiana, 70433, United States

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Houma, Louisiana, 70363, United States

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Marrero, Louisiana, 70072, United States
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Marrero, Louisiana, 70072, United States

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Metairie, Louisiana, 70006, United States

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New Orleans, Louisiana, 70112, United States

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New Orleans, Louisiana, 70121, United States

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Shreveport, Louisiana, 71105, United States

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West Monroe, Louisiana, 71291, United States

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Baltimore, Maryland, 21202, United States

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Glen Burnie, Maryland, 21061, United States

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COMPLETED

Greenbelt, Maryland, 20770, United States
Akero Clinical Study Site
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South Dartmouth, Massachusetts, 02747, United States

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Novi, Michigan, 48377, United States

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ACTIVE_NOT_RECRUITING

Southfield, Michigan, 48075, United States
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Wyoming, Michigan, 49519, United States

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ACTIVE_NOT_RECRUITING

Ypsilanti, Michigan, 48197, United States
Akero Clinical Study Site
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Flowood, Mississippi, 39232, United States

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Columbia, Missouri, 65201, United States

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Kansas City, Missouri, 64131, United States

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NOT_YET_RECRUITING

St Louis, Missouri, 63123, United States

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Las Vegas, Nevada, 89106, United States

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Las Vegas, Nevada, 89109, United States

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RECRUITING

Reno, Nevada, 89511, United States

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ACTIVE_NOT_RECRUITING

Florham Park, New Jersey, 07932, United States
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Ridgewood, New Jersey, 07450, United States

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Somers Point, New Jersey, 08244, United States

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Sparta, New Jersey, 07871, United States

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ACTIVE_NOT_RECRUITING

Santa Fe, New Mexico, 87505, United States
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Buffalo, New York, 14203, United States

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New York, New York, 10016, United States

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RECRUITING

New York, New York, 10021, United States

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RECRUITING

New York, New York, 10029, United States

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Akero Clinical Study Site
COMPLETED

New York, New York, 10033, United States
Akero Clinical Study Site
RECRUITING

Rochester, New York, 55905, United States

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Chapel Hill, North Carolina, 27514, United States

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Charlotte, North Carolina, 28204, United States

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Durham, North Carolina, 27710, United States

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Fayetteville, North Carolina, 28303, United States

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Morehead City, North Carolina, 28557, United States

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New Bern, North Carolina, 28562, United States

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RECRUITING

Raleigh, North Carolina, 27612, United States

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Akero Clinical Study Site
RECRUITING

Statesville, North Carolina, 28625, United States

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Akero Clinical Study Site
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43213, United States
Akero Clinical Study Site
RECRUITING

Dayton, Ohio, 45414, United States

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RECRUITING

Springboro, Ohio, 45066, United States

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Akero Clinical Study Site
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Westlake, Ohio, 44145, United States

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Medford, Oregon, 97504, United States

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RECRUITING

Hershey, Pennsylvania, 17033, United States

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Philadelphia, Pennsylvania, 19104, United States

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Philadelphia, Pennsylvania, 19107, United States

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Pittsburgh, Pennsylvania, 15213, United States

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NOT_YET_RECRUITING

Charleston, South Carolina, 29425, United States

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Columbia, South Carolina, 29204, United States

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Summerville, South Carolina, 29485, United States

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Chattanooga, Tennessee, 37421, United States

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Clarksville, Tennessee, 37040, United States

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Hermitage, Tennessee, 37076, United States

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Nashville, Tennessee, 37211, United States

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Amarillo, Texas, 79106, United States

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Austin, Texas, 78745, United States

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RECRUITING

Austin, Texas, 78757, United States
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Austin, Texas, 78757, United States

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Bellaire, Texas, 77401, United States

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Brownsville, Texas, 78520, United States

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Corpus Christi, Texas, 78404, United States

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Dallas, Texas, 75203, United States

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Dallas, Texas, 75216, United States

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Dallas, Texas, 75230, United States

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Dallas, Texas, 75234, United States

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Dallas, Texas, 75390, United States

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Denison, Texas, 75020, United States

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Edinburg, Texas, 78539, United States
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Edinburg, Texas, 78539, United States

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Forney, Texas, 75126, United States

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Fort Worth, Texas, 76104, United States

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ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
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RECRUITING

Houston, Texas, 77030, United States

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RECRUITING

Houston, Texas, 77074, United States

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Akero Clinical Study Site
RECRUITING

Houston, Texas, 77079, United States
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RECRUITING

Houston, Texas, 77079, United States

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ACTIVE_NOT_RECRUITING

Houston, Texas, 77084, United States
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RECRUITING

Lewisville, Texas, 75057, United States

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ACTIVE_NOT_RECRUITING

McAllen, Texas, 78504, United States
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Pasadena, Texas, 77505, United States

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San Antonio, Texas, 78209, United States

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San Antonio, Texas, 78215, United States

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RECRUITING

San Antonio, Texas, 78222, United States

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RECRUITING

San Antonio, Texas, 78229, United States
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San Antonio, Texas, 78229, United States

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San Antonio, Texas, 78240, United States

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San Antonio, Texas, 78258, United States

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San Marcos, Texas, 78666-7502, United States

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San Marcos, Texas, 78666, United States

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Waco, Texas, 76710, United States

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Waco, Texas, 76712, United States

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Webster, Texas, 77598, United States

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Wichita Falls, Texas, 76301, United States

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Ogden, Utah, 84405, United States

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Salt Lake City, Utah, 84117, United States

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Sandy City, Utah, 84092, United States

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ACTIVE_NOT_RECRUITING

South Ogden, Utah, 84405, United States
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ACTIVE_NOT_RECRUITING

Falls Church, Virginia, 22042-3300, United States
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Newport News, Virginia, 23602, United States

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Norfolk, Virginia, 23502, United States

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Richmond, Virginia, 23226, United States

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Richmond, Virginia, 23235, United States

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Richmond, Virginia, 23249, United States

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Richmond, Virginia, 23298, United States

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Roanoke, Virginia, 24014, United States

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Suffolk, Virginia, 23435, United States
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Seattle, Washington, 98105, United States

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Spokane, Washington, 99218, United States

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Madison, Wisconsin, 53705, United States

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Ciudad Autónoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina

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La Plata, Buenos Aires, B1902AWL, Argentina

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Ramos Mejía, Buenos Aires, B1704ETD, Argentina

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Buenos Aires, Distrito Federal, C1125ABE, Argentina

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Buenos Aires, C1118AAT, Argentina

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Buenos Aires, C1180AAX, Argentina

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Buenos Aires, C1280AEB, Argentina

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Broadmeadow, New South Wales, 2292, Australia

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Kogarah, New South Wales, 2217, Australia

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Liverpool, New South Wales, 1871, Australia

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Penrith, New South Wales, 2750, Australia

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Westmead, New South Wales, 2145, Australia

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Adelaide, South Australia, 5000, Australia

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Caulfield South, Victoria, 3162, Australia

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Epping, Victoria, 3076, Australia

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Frankston, Victoria, 3128, Australia

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Heidelberg, Victoria, 3084, Australia

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Melbourne, Victoria, 3004, Australia

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Murdoch, Western Australia, 6150, Australia

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Nedlands, Western Australia, 6009, Australia

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Perth, Western Australia, 6000, Australia

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Edmonton, Alberta, T6G 2X8, Canada

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Hamilton, Ontario, L8S 4K1, Canada

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Toronto, Ontario, M6H 3M1, Canada

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Vaughan, Ontario, L4L 4Y7, Canada

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Montreal, Quebec, H2X 3E4, Canada
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Montreal, Quebec, H2X 3E4, Canada

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Terrebonne, Quebec, J7B6B7, Canada

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Nice, Alpes-Maritimes, 06202, France

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Lyon, Auvergne-Rhône-Alpes, 69008, France

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Strasbourg, Bas-Rhin, 67091, France

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Limoges, Haute-Vienne, 87042, France

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Clichy, Hauts-de-Seine, 92110, France

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Vandœuvre-lès-Nancy, Lorraine, 54511, France

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Angers, Maine-et-Loire, 49933, France

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Toulouse, Occitanie, 31059, France

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Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France

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Montpellier Cedex 5, Provence-Alpes-Côte d'Azur Region, 34295, France

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Versailles, Yvelines, Île-de-France, 78000, France

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Paris, Île-de-France Region, 75013, France

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Würzburg, Bavaria, 97080, Germany

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Frankfurt am Main, Hesse, 60590, Germany
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Mainz, Rhineland-Palatinate, 55131, Germany

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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04103, Germany
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Leipzig, Saxony, 04103, Germany

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Lübeck, Schleswig-Holstein, 23538, Germany

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Berlin, 10787, Germany

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Berlin, 13353, Germany

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Surat, Gujarat, 395002, India

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Vadodara, Gujarat, 390007, India

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Thiruvananthapuram, Kerala, 695011, India

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Dahegaon, Maharashtra, 441108, India

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Nagpur, Maharashtra, 440010, India

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Pune, Maharashtra, 412201, India

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New Delhi, National Capital Territory of Delhi, 110029, India

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New Delhi, National Capital Territory of Delhi, 110060, India

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Jaipur, Rajasthan, 302001, India
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Jaipur, Rajasthan, 302001, India

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Coimbatore, Tamil Nadu, 641005, India

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Hyderabad, Telangana, 500 004, India

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Varanasi, Uttar Pradesh, 221005, India

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Kolkata, West Bengal, 700020, India
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Kolkata, West Bengal, 700020, India

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Kolkata, West Bengal, 700073, India

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Petah Tikva, Central District, 4941492, Israel

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Ramat Gan, Central District, 5265601, Israel

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Haifa, Haifa District, 3109601, Israel

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Haifa, Haifa District, 3436212, Israel

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Afula, Northern District, 1834111, Israel

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Nahariya, Northern District, 22100, Israel

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Nazareth, Northern District, 1610001, Israel

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Jerusalem, 9103102, Israel

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Jerusalem, 9112001, Israel

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Tel Aviv, 6423906, Israel

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San Giovanni Rotondo, Foggia, 71013, Italy

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Rozzano, Milan, 20089, Italy

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Torino, Turin, 10126, Italy

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Bologna, 40138, Italy

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Foggia, 71122, Italy

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Messina, 98124, Italy

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Milan, 20122, Italy
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Milan, 20122, Italy

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Modena, 41126, Italy

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Naples, 80131, Italy

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Novara, 28100, Italy

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Cuauhtémoc, Mexico City, 06700, Mexico

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Poznan, Greater Poland Voivodeship, 60-702, Poland

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Krakow, Lesser Poland Voivodeship, 31-501, Poland

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Wroclaw, Lower Silesian Voivodeship, 50-381, Poland

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Wroclaw, Lower Silesian Voivodeship, 53-673, Poland

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Warsaw, Masovian Voivodeship, 00-215, Poland

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Warsaw, Masovian Voivodeship, 02-672, Poland

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Gdansk, Pomeranian Voivodeship, 80-382, Poland

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Gdynia, Pomeranian Voivodeship, 81-537, Poland

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Częstochowa, Silesian Voivodeship, 42-202, Poland

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Katowice, Silesian Voivodeship, 40-040, Poland

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Katowice, Silesian Voivodeship, 40-081, Poland

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Lodz, Łódź Voivodeship, 90-127, Poland

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Manatí, 00674, Puerto Rico

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Mayagüez, 00680, Puerto Rico

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San Juan, 00927, Puerto Rico

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Daegu, Daegu Gwang'yeogsi [Taegu-Kwangyokshi], 41944, South Korea

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Goyang-si, Gyeonggi-do, 1232, South Korea

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Incheon, Gyeonggi-do, 22332, South Korea

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Seongnam-si, Gyeonggi-do, 13620, South Korea
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Seongnam-si, Gyeonggido [Kyonggi-do], 13520, South Korea

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Daegu, Gyeongsangbugdo [Kyongsangbuk-do], 42601, South Korea

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Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 03080, South Korea

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Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 04763, South Korea

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Sabadell, Barcelona, 08208, Spain

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Santander, Cantabria, 39008, Spain

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Majadahonda, Madrid, 28222, Spain

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Valencia, València, 46015, Spain

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Valencia, València, 46026, Spain

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Barcelona, 08035, Spain

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Madrid, 28007, Spain

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Madrid, 28027, Spain

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Seville, 41013, Spain

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Olten, Canton of Solothurn, 4600, Switzerland

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Bern, 3010, Switzerland

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Sankt Gallen, 9007, Switzerland

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Changhua, Changhua, 500, Taiwan

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Taichung, Taichung, 40447, Taiwan

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Tainan, Tainan, 73657, Taiwan

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Taipei City, Taipei, 10048, Taiwan

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Kaohsiung City, 833, Taiwan

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Tainan, 704, Taiwan

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Taoyuan District, 333, Taiwan

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Yenimahalle, Ankara, 06500, Turkey (Türkiye)

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Bornova, İzmir, 35100, Turkey (Türkiye)

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Bursa, 16059, Turkey (Türkiye)

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Rize, 53020, Turkey (Türkiye)

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Birmingham, England, B15 2WB, United Kingdom

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Cambridge, England, CB2 0QQ, United Kingdom

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Liverpool, England, L9 7AL, United Kingdom

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London, England, E1 1BB, United Kingdom

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London, England, NW3 2QG, United Kingdom

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London, England, SE5 9RS, United Kingdom

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London, England, SW10 9NH, United Kingdom

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London, England, W2 1NY, United Kingdom
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Newcastle upon Tyne, England, NE7 7DN, United Kingdom

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Conditions

Explore the condition pages connected to this study.

MASH WITH FIBROSIS NASH WITH FIBROSIS