New drug trial aims to control debilitating muscle disease

NCT ID NCT06298552

Summary

This study is testing whether an intravenous drug called efgartigimod is effective and safe for adults with a specific, hard-to-treat form of generalized myasthenia Gravis (gMG). About 119 participants will be randomly assigned to receive either the drug or a placebo for part of the study, followed by an open-label period where all receive the drug. The main goal is to see if the treatment improves patients' daily activities and muscle strength over approximately 2.5 years.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for GENERALIZED MYASTHENIA GRAVIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • AHEPA University General Hospital of Thessaloniki

    Thessaloniki, 546 36, Greece

  • AP-HM- Hôpital de La Timone

    Marseille, 13386, France

  • AP-HP - Hôpital de la Pitié Salpétrière

    Paris, 75013, France

  • AZ Sint-Lucas Gent

    Ghent, 9000, Belgium

  • Aarhus Universitetshospital

    Aarhus, 8200, Denmark

  • BayCare - St. Anthony's Hospital

    St. Petersburg, Florida, 33705-1410, United States

  • CHU de Nice-Hôpital Pasteur

    Nice, 06000, France

  • CLINIREM Sp z o.o.

    Lublin, 20-883, Poland

  • Centrum Medyczne Neurologia Slaska

    Katowice, 40-689, Poland

  • Charité - Universitätsmedizin Berlin

    Berlin, 13353, Germany

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Cluj County Emergency Clinical Hospital

    Cluj-Napoca, 400012, Romania

  • Cyprus Institute of Neurology and Genetics

    Égkomi, 2371, Cyprus

  • Desai Sethi Medical Center

    Miami, Florida, 33136, United States

  • Duke University School of Medicine - Duke Early Phase Clinical Research Unit

    Durham, North Carolina, 27710, United States

  • Eginitio Hospital

    Athens, 115 28, Greece

  • Erlanger Neuroscience Institute

    Chattanooga, Tennessee, 37403-2173, United States

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • First Choice Neurology Boca Raton

    Boca Raton, Florida, 33428, United States

  • First Hospital of Shanxi Medical University

    Taiyuan, 030001, China

  • Fujian Medical University Union Hospital

    Fuzhou, 350001, China

  • Genge Partners Inc.

    Montreal, H4A 3T2, Canada

  • Guangdong Province Traditional Chinese Medical Hospital

    Guangzhou, 518053, China

  • Haukeland Universitetssykehus

    Bergen, 5021, Norway

  • Heritage Medical Research Clinic

    Calgary, T2N 4Z6, Canada

  • HonorHealth Neurology - Bob Bove Neuroscience Institute

    Scottsdale, Arizona, 85251, United States

  • Hospital Clinico Universitario de Santiago

    Santiago de Compostela, 15706, Spain

  • Hospital General Universitario Dr. Balmis

    Alicante, 03010, Spain

  • Hospital Universitari Arnau de Vilanova

    Lleida, 25198, Spain

  • Hospital Universitari i Politecnic La Fe de Valencia

    Valencia, 46026, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28304, Spain

  • Hospital Universitario Vall d'Hebron - PPDS

    Barcelona, 8035, Spain

  • Hospital de La Santa Creu i Sant Pau

    Barcelona, 8041, Spain

  • Hospital de Santo António - Unidade Local de Saúde de Santo António

    Porto, 4050-011, Portugal

  • Huashan Hospital Fudan University

    Shanghai, 200040, China

  • Hôpital Erasme

    Anderlecht, 1070, Belgium

  • Kansas University Medical Center - Kansas City

    Fairway, Kansas, 66205, United States

  • Katholisches Klinikum Bochum - St. Josef Hospital

    Bochum, 44791, Germany

  • King Faisal Specialist Hospital & Research Center

    Riyadh, 11211, Saudi Arabia

  • Krakowska Akademia Neurologii Sp. z o.o.

    Krakow, 31-505, Poland

  • LLC Caucasus Medical Centre

    Tbilisi, 0186, Georgia

  • Leeds General Infirmary

    Leeds, LS1 3EX, United Kingdom

  • Leiden University Medical Center

    Leiden, 2333 ZA, Netherlands

  • Loma Linda University Health

    Fresno, California, 93701-2234, United States

  • MICS Centrum Medyczne Bydgoszcz

    Bydgoszcz, 85-065, Poland

  • Medsol Clinical Research Center Inc

    Port Charlotte, Florida, 33952, United States

  • National Guard Riyadh

    Riyadh, 14611, Saudi Arabia

  • National Neuromuscular Research Institute

    Austin, Texas, 78756, United States

  • Nemocnice Pardubickeho kraje, a.s., Pardubicka nemocnice

    Pardubice, 530 03, Czechia

  • Neurology Associates PA

    Maitland, Florida, 32751, United States

  • New Hospitals

    Tbilisi, 0114, Georgia

  • Ningbo Medical Center Lihuili Hospital

    Ningbo, 315041, China

  • Odense Universitetshospital

    Odense C, 5000, Denmark

  • Opsta bolnica MSB - Medicinski Sistemi Beograd

    Belgrade, 11000, Serbia

  • Oslo Universitetssykehus HF, Ullevål

    Oslo, 424, Norway

  • Ottawa Hospital - Civic Campus

    Ottawa, K1H 8L6, Canada

  • Panthera Biopartners

    Glasgow, G51 4TY, United Kingdom

  • Petre Sarajishvili Institute of Neurology

    Tbilisi, 0112, Georgia

  • Pineo Medical Ecosystem

    Tbilisi, 0112, Georgia

  • Qilu Hospital of Shandong University

    Qingdao, 266035, China

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Rutgers-Robert Wood Johnson Medical School

    New Brunswick, New Jersey, 08901-1962, United States

  • SFM Clinical Research LLC

    Boca Raton, Florida, 33487, United States

  • Semmelweis Egyetem Genomikai Medicina és Ritka Betegségek Intézete

    Budapest, 1082, Hungary

  • Sibiu Emergency County Clinical Hospital

    Sibiu, 550166, Romania

  • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

    Chongqing, 400016, China

  • Szpital Uniwersytecki w Krakowie

    Krakow, 31-503, Poland

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, 550004, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, 400016, China

  • The First Affiliated Hospital of Guangxi Medical University

    Guangxi, 530021, China

  • The First Affiliated Hospital of Guangzhou University Chinese Medicine

    Guangzhou, 510405, China

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • The Neurology Institute / Healthcare Innovations Institute - Coral Springs

    Coral Springs, Florida, 33067, United States

  • Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, 430030, China

  • Turun Yliopistollinen Keskussairaala

    Turku, 20540, Finland

  • ULS de Lisboa Ocidental, EPE - Hospital Egas Moniz

    Lisbon, 1349-019, Portugal

  • ULS de Santa Maria, EPE - Hospital de Santa Maria

    Lisbon, 1150-199, Portugal

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX, Netherlands

  • University Clinical Center Kragujevac

    Kragujevac, 34000, Serbia

  • University General Hospital ''ATTIKON''

    Chaïdári, 124 62, Greece

  • University General Hospital of Patras

    Pátrai, 265 04, Greece

  • University of North Carolina - Chapel Hill

    Chapel Hill, North Carolina, 27599-7025, United States

  • University of South Florida (USF) Health - Morsani Center for Advanced Healthcare

    Tampa, Florida, 33612, United States

  • University of Washington Medical Center - Montlake

    Seattle, Washington, 98195, United States

  • Universitätsklinikum Würzburg

    Würzburg, 97080, Germany

  • Uniwersytecki Szpital Kliniczny im. Jana Mikulicza Radeckiego we Wroclawiu

    Wroclaw, 50-556, Poland

  • Wellstar - Augusta University Medical Center

    Augusta, Georgia, 30912, United States

  • West Georgia Medical Center

    Kutaisi, 4600, Georgia

  • Xuanwu Hospital Capital Medical University

    Beijing, 100053, China

Conditions

Explore the condition pages connected to this study.