MRNA therapy hopes to fix copper problem in wilson disease
NCT ID NCT07240896
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a new mRNA drug called DSL101 in 18 adults with Wilson disease, a genetic condition that causes copper buildup. The drug is designed to help the body produce a protein that controls copper. Participants receive low, medium, or high doses by IV every four weeks. The main goal is to check safety, but researchers will also measure copper levels in urine and blood to see if the treatment works.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
DSL101 (ATP7B mRNA/LNP)
What this could lead to
If successful, this could point toward a treatment that helps the body manage copper levels, potentially reducing symptoms and complications of Wilson disease.
What could go wrong
This is a very early, small trial (18 people) focused on safety. It may not show clear benefit, and risks like infusion reactions or immune responses are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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The First Affiliated Hospital of Anhui Medical University
RECRUITINGHefei, Anhui, 230000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••