New immune combo shows promise against stubborn lymphoma

NCT ID NCT03349450

First seen May 07, 2026 · Last updated May 07, 2026

Summary

This study tested a combination of three drugs—DPX-Survivac, low-dose cyclophosphamide, and pembrolizumab—in 25 adults with diffuse large B-cell lymphoma that had come back or not responded to prior treatments. The goal was to see if the immune system could be better activated to shrink tumors. Participants received injections and pills over up to one year, and the study measured how many people's tumors shrank or disappeared.

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Contacts and locations

Locations

  • London Health Sciences Centre

    London, Ontario, N6A 5W9, Canada

  • McGill University Health Centre

    Montreal, Quebec, Canada

  • Nova Scotia Health Authority: Queen Elizabeth II Health Sciences Centre

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, Canada

  • Sunnybrook Health Sciences Centre, Odette Cancer Centre

    Toronto, Ontario, M4N 3M5, Canada

  • Tom Baker Cancer Centre - Alberta Health Services

    Calgary, Alberta, Canada

Conditions

Explore the condition pages connected to this study.