Double immune attack: new combo aims to boost CAR-T success in tough lymphoma
NCT ID NCT07542678
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding a drug called glofitamab before and after standard CAR-T cell therapy can improve outcomes for 20 adults with high-risk, relapsed or refractory large B-cell lymphoma. Participants first receive glofitamab with chemotherapy, then CAR-T cells, followed by more glofitamab. The main goal is to see how many achieve complete remission by the end of treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Glofitamab, gemcitabine, and oxaliplatin
- What this could lead to
- If successful, this combination approach could improve the chance of complete remission for patients with hard-to-treat lymphoma who are eligible for CAR-T therapy.
- What could go wrong
- This is a small, early-phase trial with only 20 participants, so results may not apply broadly. The added drugs also carry risks like infection and organ damage.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Charité - Universitätsmedizin Berlin - Campus Benjamin Franklin
Berlin, State of Berlin, 12203, Germany
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Universitätsklinikum Düsseldorf - Klinik für Hämatologie, Onkologie und klinische Immunologie
Düsseldorf, North Rhine-Westphalia, 40225, Germany
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Universitätsklinikum Essen (AöR) - Westdeutsches Tumorzentrum Essen - Klinik für Hämatologie und Stammzellltransplantation
Essen, North Rhine-Westphalia, 45147, Germany
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Universitätsklinikum Heidelberg - Innere Medizin V
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Universitätsklinikum Münster - Medizinische Klinik A
Münster, North Rhine-Westphalia, 48149, Germany
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