New drug combo aims to outperform standard care in Tough-to-Treat stomach cancers

NCT ID NCT05568095

Ongoing Disease control Sponsor: Arcus Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 16, 2026 · Updated 28 times

Summary

This large Phase 3 trial compares a new two-drug immunotherapy (domvanalimab and zimberelimab) plus chemotherapy against the standard immunotherapy (nivolumab) plus chemotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that hasn't been treated yet. The study aims to see if the new combination helps people live longer and keeps the cancer from growing. About 1,040 participants will be enrolled, and the main focus is on overall survival.

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Contacts and locations

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Locations

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Hot Springs, Arkansas, 71913, United States
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Los Angeles, California, 90027, United States
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Los Angeles, California, 90033, United States
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Orange, California, 92868, United States
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Santa Monica, California, 90404, United States
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New Haven, Connecticut, 06520, United States
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Washington D.C., District of Columbia, 22057, United States
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Fort Myers, Florida, 33901, United States
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St. Petersburg, Florida, 33705, United States
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Tallahassee, Florida, 32308, United States
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Louisville, Kentucky, 40202, United States
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Louisville, Kentucky, 40217, United States
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New Orleans, Louisiana, 70121, United States
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Boston, Massachusetts, 02114, United States
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Ann Arbor, Michigan, 48109, United States
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Saint Louis Park, Minnesota, 55426, United States
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Mineola, New York, 11501, United States
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New York, New York, 10016, United States
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New York, New York, 10065, United States
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Durham, North Carolina, 27710, United States
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Cleveland, Ohio, 44106, United States
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Cleveland, Ohio, 44111, United States
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Columbus, Ohio, 43219, United States
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Mayfield Heights, Ohio, 44124, United States
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Portland, Oregon, 97225, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Dallas, Texas, 75390, United States
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Fort Worth, Texas, 76104, United States
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Houston, Texas, 77054, United States
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Fairfax, Virginia, 22031, United States
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Seattle, Washington, 98109, United States
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Milwaukee, Wisconsin, 53226, United States
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Buenos Aires, Argentina
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La Rioja, Argentina
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Mar del Plata, Argentina
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Clayton, Australia
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Murdoch, Australia
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Barretos, Brazil
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Ijuí, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Halifax, Canada
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Montreal, Canada
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Ottawa, Canada
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Toronto, Canada
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La Florida, Chile
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Port Montt, Chile
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Providencia, Chile
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Recoleta, Chile
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Santiago, Chile
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Talca, Chile
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Changchun, China
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Changzhou, China
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Fuzhou, China
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Guangzhou, China
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Haikou, China
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Hangzhou, China
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Hefei, China
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Shanghai, China
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Tianjin, China
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Zhengzhou, China
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Bordeaux, France
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Brest, France
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Caen, France
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Lille, France
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Lyon, France
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Montpellier, France
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Plérin, France
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Poitiers, France
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Toulouse, France
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Villejuif, France
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Kutaisi, 4600, Georgia
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Tbilisi, 112, Georgia
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Tbilisi, 144, Georgia
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Tbilisi, 159, Georgia
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Tbilisi, 186, Georgia
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Guatemala City, Guatemala
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Quetzaltenango, Guatemala
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Happy Valley, Hong Kong
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Hong Kong, Hong Kong
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Tuenmen, Hong Kong
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Budapest, Hungary
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Kecskemét, Hungary
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Pécs, Hungary
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Jerusalem, Israel
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Petah Tikva, Israel
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Tel Aviv, Israel
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Florence, Italy
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Milan, Italy
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Milan, Italy
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Ravenna, Italy
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Rozzano, Italy
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Udine, Italy
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Akashi, Japan
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Bunkyō City, Japan
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Chiba, Japan
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Fukuoka, Japan
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Kashiwa-shi, Japan
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Kawasaki, Japan
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Kōtō City, Japan
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Matsuyama, Japan
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Nagaizumi-cho, Japan
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Nagoya, Japan
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Niigata, Japan
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Osaka, Japan
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Osakasayama-shi, Japan
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Ota-shi, Japan
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Saitama, Japan
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Tokyo, Japan
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Yokohama, Japan
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Kaunas, Lithuania
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Klaipėda, Lithuania
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Vilnius, Lithuania
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George Town, Malaysia
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Kuala Lumpur, Malaysia
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Kuching, Malaysia
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Colonia Centro, 94300, Mexico
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Mexico City, 3100, Mexico
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Mérida, 97134, Mexico
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San Pedro Garza García, 66278, Mexico
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Toluca, 50120, Mexico
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San Isidro, Peru
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San Juán de Miraflores, Peru
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Surquillo, Peru
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Bacolod City, Philippines
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Baguio City, Philippines
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Cebu City, Philippines
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Manila, Philippines
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Lublin, Poland
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Tychy, Poland
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Warsaw, Poland
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Coimbra, Portugal
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Lisbon, Portugal
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Porto, Portugal
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Baia Mare, Romania
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Bucharest, Romania
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Cluj-Napoca, Romania
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Craiova, Romania
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Florești, Romania
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Iași, Romania
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Suceava, Romania
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Belgrade, Serbia
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Kragujevac, Serbia
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Busan, South Korea
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Daegu, South Korea
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Seongnam, South Korea
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Seoul, South Korea
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Barcelona, Spain
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Madrid, Spain
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Santander, Spain
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Valencia, Spain
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Zaragoza, Spain
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Bang Phlat, Thailand
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Hat Yai, Thailand
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Ubon Ratchathani, Thailand
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Adana, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Edirne, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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İzmit, Turkey (Türkiye)
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Malatya, Turkey (Türkiye)
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Mamak, Turkey (Türkiye)
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Van, Turkey (Türkiye)
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Yakutiye, Turkey (Türkiye)
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Yüreğir, Turkey (Türkiye)
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London, United Kingdom
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Manchester, United Kingdom
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Oxford, United Kingdom
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Sutton, United Kingdom

Conditions

Explore the condition pages connected to this study.

ADVANCED UPPER GASTROINTESTINAL TRACT ADENOCARCINOMA