New hope for Tough-to-Treat blood cancer: major trial tests powerful drug combo

NCT ID NCT04404283

Ongoing Disease control Sponsor: Seagen, a wholly owned subsidiary of Pfizer Source: ClinicalTrials.gov ↗

Summary

This study is for people with an aggressive type of blood cancer called DLBCL that has returned or not responded to at least two prior treatments. It tests whether adding a drug called brentuximab vedotin to the standard two-drug therapy (lenalidomide and rituximab) helps patients live longer and better control the cancer compared to the standard therapy alone. About 238 participants will be randomly assigned to receive either the three-drug combination or the standard two-drug combination plus a placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Aalborg University Hospital

Aalborg, 9000, Denmark
Aarhus University Hospital

Aarhus N, 8200, Denmark
Asan Medical Center

Seoul, 05505, South Korea
Assaigs Clfnics-Servei de Farmacia

Barcelona, 08003, Spain
Azienda Ospedaliera "Cardinale Giovanni Panico", U.O.C. Ematologia e Trapianti Midollo Osseo

Tricase, Lecce, 73039, Italy
Azienda Ospedaliero-Universitaria di Bologna - IRCCS

Bologna, Other, 40138, Italy
Barnes Jewish-Hospital

St Louis, Missouri, 63110, United States
Bellberry Limited

Eastwood, Australia
Breakthrough Haematology Hollywood Specialist Centre

Nedlands, Western Australia, 6009, Australia
CETIR

Barcelona, 08029, Spain
CHR Metz-Thionville Hopital Mercy

Metz, 57085, France
CHRU Hopital de Tours

Tours, 37000, France
CHRU de Nancy - Hopitaux de Brabois, Service Hematologie et Medecine interne

Vandœuvre-lès-Nancy, Cedex 54511, France
CHU Angers - Hotel Dieu Nord, Service des Maladies du Sang

Angers, 49933 Cedex 9, France
CHU Grenoble Alpes

Grenoble, 38043 Cedex 9, France
CHU UCL Namur-

Yvoir, Namur, 5530, Belgium
CISSS de la Monteregie-Centre

Greenfield Park, Quebec, J4V 2H1, Canada
Central Alabama Research

Birmingham, Alabama, 35209, United States
Central Coast Local Health District Wyong Hospital

Hamlyn Terrace, New South Wales, 2259, Australia
Central Coast Local Health District, Gosford Hospital

Gosford, New South Wales, 2250, Australia
Centre Antoine Lacassagne

Nice, 06189 Cedex 2, France
Centre Henri Becquerel

Rouen, 76038, France
Centre Hospitalier Le Mans

Le Mans, 72000, France
Centre Hospitalier Metropole Savoie

Chambéry, 73000, France
Centre Hospitalier Sud Francilien (CHSF)

Corbeil-Essonnes, 91106 cedex, France
Centre Hospitalier Universitaire Nantes-Hotel Dieu, Service d'Hematologie

Nantes, Cedex 144093, France
Centre Hospitalier(CH) de Perpignan

Perpignan, Other, 66000, France
Centre Integre Universitaire De Sante et de Services Sociaux Du Nord-de-I'ile-de-Montreal

Montreal, Quebec, H4J 1C5, Canada
Centre Integre Universitaire de la Santé et de Services Sociaux de l'Est-de-l'ile-de-Montreal,

Montreal, Quebec, H1T 2M4, Canada
Centre de Lutte Contre le Cancer (CLCC) - Institut Bergonie

Bordeaux, Other, 33000, France
Centre de Lutte Contre le Cancer (CLCC) - lnstitut Bergonie Pharmacie

Bordeaux, 33000, France
Centro de Diagnostico y Resonancia Magnetica

Salamanca, 37004, Spain
Chang Gung Medical Foundation

Kaohsiung City, 833, Taiwan
Chang Gung Medical Foundation, Linkou Chang Gung Memorial Hospital

Taoyuan District, 333, Taiwan
Chi Mei Hospital, Liouying

Tainan, 73657, Taiwan
Chi Mei Medical Center, Liouying

Tainan, 736, Taiwan
Chu Helora

Haine-Saint-Paul, 7100, Belgium
Clinica Universidad de Navarra

Pamplona, Navarre, 31008, Spain
Clinical Trial Unit 2081

Copenhagen, 2100, Denmark
Complejo Hospitalario de Navarra

Pamplona, Navarre, 31008, Spain
Dong-A University Hospital.

Busan, 49201, South Korea
Eastern Regional Health Authority

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
FUNDAClON GENERAL UNIVERSIDAD DE MALAGA (FGUMA)

Málaga, 29071, Spain
Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia
Florida Cancer Specialists

Bonita Springs, Florida, 34135, United States
Florida Cancer Specialists

Bradenton, Florida, 34211, United States
Florida Cancer Specialists

Cape Coral, Florida, 33909, United States
Florida Cancer Specialists

Daytona Beach, Florida, 32117, United States
Florida Cancer Specialists

Fort Myers, Florida, 33905, United States
Florida Cancer Specialists

Fort Myers, Florida, 33908, United States
Florida Cancer Specialists

Naples, Florida, 34102, United States
Florida Cancer Specialists

Port Charlotte, Florida, 33980, United States
Florida Cancer Specialists

Sarasota, Florida, 34232, United States
Florida Cancer Specialists

Sarasota, Florida, 34236, United States
Florida Cancer Specialists

Stuart, Florida, 34994, United States
Florida Cancer Specialists

Venice, Florida, 34285, United States
Florida Cancer Specialists

Venice, Florida, 34292, United States
Florida Cancer Specialists

Vero Beach, Florida, 32960, United States
Florida Cancer Specialists

Wellington, Florida, 33414, United States
Florida Cancer Specialists

West Palm Beach, Florida, 33401, United States
Gachon University Gil Medical Center

Incheon, 21565, South Korea
Guy's and St Thomas' NHS Foundation Trust

London, SE1 9RT, United Kingdom
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Medical Center - Columbus

Novi, Michigan, 48377, United States
Hollywood Haematology

Nedlands, 6009, Australia
Hollywood Private Hospital

Nedlands, Western Australia, 6009, Australia
Hopital Saint-Antoine -

Paris, 75012, France
Hospital Clinico Universitario de Salamanca

Salamanca, 37007, Spain
Hospital Costa del Sol

Marbella, Malaga, 29603, Spain
Hospital La Milagrosa

Madrid, 28010, Spain
Hospital Quiron

Barcelona, 08023, Spain
Hospital Quironsalud Barcelona

Barcelona, 08023, Spain
Hospital Rey Juan Carlos

Móstoles, 28933, Spain
Hospital San Pedro de Alcantara

Cáceres, Extremadura, 10003, Spain
Hospital San Pedro de Alcantara

Cáceres, Extremadura, 10005, Spain
Hospital San Pedro de Alcantara

Cáceres, 10005, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28080, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario QuironSalud Madrid

Pozuelo de Alarcón, Madrid, 28223, Spain
Hospital Universitario QuironSalud Madrid

Pozuelo de Alarcon (madrid), 28223, Spain
Hospital Universitario de Badajoz

Badajoz, 06080, Spain
Hospital de Navarra

Pamplona, Navarre, 31008, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 08029, Spain
Hospital del Mar

Barcelona, Other, 08003, Spain
Hôpital Lyon Sud

Pierre-Bénite, Other, 69310, France
ICON Laboratory Services

Leopardstown, Other, Dublin 18, Ireland
IP ADDRESS: Brigitte Harris Cancer Pavilion (BHCP)

Detroit, Michigan, 48202, United States
IRCCS Istituto Tumori Giovanni Paolo II U.O. Ematologia

Bari, Apulia, 70124, Italy
Inje University Busan Paik Hospital

Busan, 47392, South Korea
Institut Gustave Roussy Département d'Innovations Thérapeutiques et d'Essais Précoces (DITEP)

Villejuif, 94805 Cedex, France
Istituto Europeo di Oncologia

Milan, MI, 20141, Italy
Jeonbuk National University Hospital

Jeonju, Jeollabuk-do, 54907, South Korea
Kantonsapotheke Zurich

Schlieren, 8952, Switzerland
Kantonsspital Winterthur, Medizinische Onkologie

Winterthur, Canton of Zurich, 8401, Switzerland
Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Karmanos Cancer Institute Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
Keimyung University Dongsan Hospital

Daegu, 42601, South Korea
Lekarna Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia
London Health Sciences Centre

London, Ontario, N6A 5W9, Canada
MidAmerica Division, Inc. c/o Centerpoint Medical Center

Independence, Missouri, 64057, United States
MidAmerica Division, Inc. c/o Menorah Medical Center

Overland Park, Kansas, 66209, United States
MidAmerica Division, Inc., c/o Research Medical Center

Kansas City, Missouri, 64132, United States
Nasz Lekarz Osrodek Badan Klinicznych

Torun, 87-100, Poland
National Cancer Center

Goyang-si, Gyeonggi-do, 10408, South Korea
National Cheng Kung University Hospital

Tainan, 704, Taiwan
National Taiwan University Hospital

Taipei, R.o.c, 100, Taiwan
National Taiwan University Hospital Clinical Trial Pharmacy

Taipei, R.o.c, 100, Taiwan
Nuklearmedicin

Copenhagen, 2100, Denmark
Oncology Associates of Oregon, P.C.

Eugene, Oregon, 97401, United States
Oncology_Hematology Care Clinical Trials,LLC

Cincinnati, Ohio, 45211, United States
Oncology_Hematology Care Clinical Trials,LLC

Cincinnati, Ohio, 45236, United States
Oncology_Hematology Care Clinical Trials,LLC

Cincinnati, Ohio, 45242, United States
Oncology_Hematology Care Clinical Trials,LLC

Cincinnati, Ohio, 45245, United States
Oncology_Hematology Care Clinical Trials,LLC

Fairfield, Ohio, 45014, United States
Ospedale Maggiore ASUGI

Trieste, 34125, Italy
Pharmacie Hopital Haut-Leveque Unite des Essais Cliniques

Pessac, 33604 Cedex, France
Pharmacie a Usage lnterieur CHU de LIMOGES

Limoges, 87042 Cedex, France
Pharmacy Department, Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Pratia MCM Krakow

Krakow, 30-510, Poland
Pusan National University Hospital

Busan, 49241, South Korea
Queen Elizabeth II Health Science Centre

Halifax, Nova Scotia, B3H 2Y9, Canada
Ramsay National Research Unit and Research Governance Office

Greenslopes, Australia
Roper St. Francis Healthcare

Charleston, South Carolina, 29414, United States
Roper St. Francis Healthcare

Mt. Pleasant, South Carolina, 29464, United States
Roper St. Francis Healthcare

North Charleston, South Carolina, 29406, United States
Royal Adelaide Hospital

Adelaide, 5000, Australia
Royal Hobart Hospital

Hobart, Tasmania, 7000, Australia
Samsung Medical Center

Seoul, 06351, South Korea
Service Pharmacie Essais Cliniques Centre Hospitalier (CH) de Perpignan

Perpignan, 66000, France
Service d'Hematologie Clinique

Limoges, 87042, France
Service d'Hematologie clinique et Therapie cellulaire CHU Bordeaux Hopital Haut-Leveque

Pessac, 33600, France
Service de Radiologie ,Centre Henri Becquerel

Rouen, 76038, France
Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea
Siteman Cancer Center - North County

St Louis, Missouri, 63136, United States
Siteman Cancer Center - South County

St Louis, Missouri, 63129, United States
Siteman Cancer Center - St. Peters

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center - West County

Creve Coeur, Missouri, 63141, United States
SoonChunHyang University Hospital Seoul

Seoul, 04401, South Korea
St Bartholomew's hospital

London, EC1A 7BE, United Kingdom
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Tasmania Health and Medical HREC

Hobart, Australia
The Catholic University of Korea

Suwon, Gyeonggi-do, 16247, South Korea
The Catholic University of Korea, Seoul Saint Mary's Hospital

Seoul, 06591, South Korea
The Ottawa Hospital - General Campus

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom
The Royal Marsden NHS Foundation Trust

Sandwich, CT13 9ND, United Kingdom
US Oncology Investigational Product Center (IPC)

Irving, Texas, 75063, United States
US Oncology Investigational Products Center

Irving, Texas, 75063, United States
Univ. Hospital Basel

Basel, Canton of Basel-City, 4032, Switzerland
Universitair Ziekenhuis Antwerpen

Edegem, 2650, Belgium
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium
Universitatsspital Basel

Basel, 4031, Switzerland
Universitatsspital Zurich

Zurich, Other, 8091, Switzerland
University Hospitals Birmingham NHS Foundation Trust

Birmingham, WEST Midlands, B15 2TH, United Kingdom
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of California Davis Medical Center

Sacramento, California, 95817, United States
University of Cincinnati Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Medical Center IDS Pharmacy

Cincinnati, Ohio, 45219, United States
University of Maryland, Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States
University of Virginia Cancer Center.

Charlottesville, Virginia, 22903, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States
Voxel S.A.

Krakow, 30-006, Poland
Washington University School of Medicine - Siteman Cancer Center

St Louis, Missouri, 63110, United States
West Chester Hospital

West Chester, Ohio, 45069, United States
Willamette Valley Cancer Institute and Research Center

Eugene, Oregon, 97401, United States
ZNA Cadix

Antwerp, 2030, Belgium
ZNA Middelheim

Antwerp, 2020, Belgium
Zaklad Rentgena i Usg - Wyrobek Sp. z o.o. sp. k

Krakow, 31-202, Poland
Zaklad Rentgena i Usg - Wyrobek Sp. z o.o. sp. k

Krakow, 31-216, Poland
Zealand University Hospital Roskilde

Roskilde, 4000, Denmark

Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B-CELL LYMPHOMA