New drug may scratch the itch for dialysis patients

NCT ID NCT05885737

Completed Symptom relief Sponsor: Vifor Fresenius Medical Care Renal Pharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a drug called difelikefalin to see if it can reduce moderate-to-severe itching in Chinese adults on hemodialysis. 260 participants received either the drug or a placebo three times a week for 12 weeks. The main goal was to measure changes in itching intensity using a daily rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Difelikefalin injection
What this could lead to: If it works, this could provide a new treatment to ease severe itching in people on dialysis, improving their quality of life.
What could go wrong: This is a completed phase 3 trial, but results are not yet published. The drug may not work better than placebo, and side effects are possible.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

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Contacts and locations

Locations

Investigator Site 01

Beijing, China
Investigator Site 02

Lanzhou, China
Investigator Site 03

Nanjing, China
Investigator Site 04

Ürümqi, China
Investigator Site 06

Guangzhou, China
Investigator Site 07

Beijing, China
Investigator Site 08

Shihezi, China
Investigator Site 10

Nanjing, China
Investigator Site 11

Yangzhou, China
Investigator Site 12

Jiaxing, China
Investigator Site 13

Xiamen, China
Investigator Site 15

Xianyang, China
Investigator Site 16

Shenzhen, China
Investigator Site 17

Wuhan, China
Investigator Site 18

Shenyang, China
Investigator Site 19

Nanjing, China
Investigator Site 20

Taiyuan, China
Investigator Site 21

Shenyang, China
Investigator Site 22

Xining, China
Investigator Site 23

Zhengzhou, China
Investigator Site 24

Taiyuan, China
Investigator Site 25

Baotou, China
Investigator Site 26

Changsha, China
Investigator Site 29

Yinchuan, China
Investigator Site 30

Yibin, China
Investigator Site 31

Zhenjiang, China
Investigator Site 32

Shijiazhuang, China
Investigator Site 33

Wuxi, China
Investigator Site 34

Mianyang, China
Investigator Site 35

Zhuzhou, China
Investigator Site 36

Nantong, China
Investigator Site 38

Xinxiang, China
Investigator Site 39

Tianjin, China
Investigator Site 40

Shanghai, China
Investigator Site 41

Shijiazhuang, China

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