New eye drops aim to stop itching and eye damage from severe allergies

NCT ID NCT07395232

Recruiting now Symptom relief Sponsor: Dompé Farmaceutici S.p.A Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests DFL24498 eye drops in 138 adults with atopic keratoconjunctivitis (AKC), a severe allergic eye condition. The drops are given twice daily for 12 weeks to see if they reduce eye itching and corneal damage compared to a placebo. Participants must have AKC in both eyes and other allergic conditions like eczema or asthma.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DFL24498 eye drop solution
What this could lead to: If successful, this could provide a new treatment option to ease severe eye itching and surface damage in people with AKC.
What could go wrong: This is still an early Phase 3 trial with only 138 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

atopic keratoconjunctivitis Bronchiolitis Obliterans Syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATOPIC KERATOCONJUNCTIVITIS

Contacts and locations

Locations

AOU Policlinico Umberto I
RECRUITING

Roma, 00161, Italy
Azienda Ospedaliera Universitaria Integrata Verona
RECRUITING

Verona, 37134, Italy
Azienda Ospedaliero Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Baylor University Jamail Specialty Care Center- Alkek Eye Center- Ophthalmology
RECRUITING

Houston, Texas, 77030, United States
Bowden Eye Associates - Southside Location
RECRUITING

Jacksonville, Florida, 32256, United States
Clayton Eye Clinical Research
RECRUITING

Morrow, Georgia, 30260, United States
Duke Eye Center - Ophthalmology
RECRUITING

Durham, North Carolina, 27710, United States
Fondazione Policlinico Universitario Campus Bio-Medico
RECRUITING

Roma, 00128, Italy
Fundación de Oftalmología Médica de la Comunitat Valenciana (FOM)
RECRUITING

Valencia, 46015, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
IRCCS AOU di Bologna - Policlinico Sant'Orsola UO Oftalmologia
RECRUITING

Bologna, 40138, Italy
METAVISION ARRUZAFA S.L. (Hospital Arruzafa)
RECRUITING

Córdoba, 14012, Spain
Miranza Galicia
RECRUITING

Santiago de Compostela, 15706, Spain
NYU Langone Health - Eye Center
RECRUITING

New York, New York, 10017, United States
OBA - Universidad de Valladolid
RECRUITING

Valladolid, 47011, Spain
Ophthalmology Associates
RECRUITING

St Louis, Missouri, 63131, United States
Ospedale SS Annunziata, ASL 2 Lanciano Vasto Chieti
RECRUITING

Chieti, 66100, Italy
Total Eye Care, PA
RECRUITING

Memphis, Tennessee, 38119, United States
University of Miami, Miller School of Medicine, Bascom Palmer Eye Institute
RECRUITING

Miami, Florida, 33136, United States