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Could a simple sedative give you a better Night's sleep after knee surgery?

NCT ID NCT07767383

Symptom relief Sponsor: Affiliated Hospital of Nantong University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This trial tests whether giving a sedative called dexmedetomidine during knee arthroscopy, along with a nerve block, can improve sleep quality in the first two days after surgery. Adults aged 18-85 scheduled for knee arthroscopy will receive either dexmedetomidine or a placebo, combined with one of two types of nerve blocks. Sleep quality will be measured using a standard questionnaire at 24 and 48 hours after surgery. The goal is to see if this approach can help patients rest better and recover more comfortably.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine (an intravenous sedative) combined with either femoral nerve block or adductor canal block (local anesthetics like ropivacaine)
What this could lead to
If effective, this combination could become a standard approach to improve sleep and recovery after knee surgery, potentially reducing pain and improving patient satisfaction.
What could go wrong
This is a single-center trial with a modest sample size, and results may not apply broadly. Dexmedetomidine can cause low blood pressure or slow heart rate, and nerve blocks carry small risks of nerve damage or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 136 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 to 85 years. 2. American Society of Anesthesiologists (ASA) physical status I to III. 3. Body Mass Index (BMI) between 18 and 30 kg/m² and body weight \> 50 kg. 4. Scheduled for elective knee arthroscopy under general anesthesia. 5. Complete preoperative workup, confirmed diagnosis, and indication for knee arthroscopy with complete postoperative medical records. 6. Normal mental and cognitive status. 7. Patient or legally authorized representative has provided written informed consent for anesthesia and study participation. Exclusion Criteria: 1. Refusal to participate in the study. 2. Inability to communicate effectively. 3. Known allergy or contraindication to any study drug (ropivacaine, dexmedetomidine, propofol, sufentanil, remifentanil, vecuronium, or sevoflurane). 4. History of knee trauma or knee surgery; diagnosed with immune system disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus); neuromuscular diseases or psychiatric disorders; restless legs syndrome (RLS); periodic limb movement disorder (PLMD). 5. Coagulation disorders or local infection at the puncture site precluding peripheral nerve block. 6. Severe hepatic or renal dysfunction. 7. Severe cardiopulmonary insufficiency. 8. Pregnancy. 9. Diagnosis of obstructive sleep apnea (OSA) or requirement for continuous positive airway pressure (CPAP) therapy. 10. Regular use of sedative-hypnotic drugs (benzodiazepines, non-benzodiazepine hypnotics, melatonin receptor agonists, etc.) or antidepressants/anxiolytics known to affect sleep architecture (e.g., trazodone, mirtazapine) within the past 1 month. 11. Pittsburgh Sleep Quality Index (PSQI) score \> 5.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee arthroscopic surgery

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

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Contacts and locations

Locations

  • The Affiliated Hospital of Nantong University

    RECRUITING

    Nantong, Jiangsu, 211600, China

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