Two-Drug cocktail may ease agitation in elderly after anesthesia
NCT ID NCT05769530
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether giving two drugs—dexmedetomidine and nalbuphine—during surgery helps elderly patients (age 60+) recover more calmly from general anesthesia. The goal was to reduce agitation, pain, and coughing right after waking up. 360 patients were split into groups, with one group receiving the drug combo and the other a placebo. The main focus was on how agitated patients were in the first 30 minutes after the breathing tube was removed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine and nalbuphine
What this could lead to
If it works, this could lead to a standard way to help elderly patients wake up more comfortably after surgery, with less confusion and pain.
What could go wrong
This is a small, completed Phase 4 trial. Results may not apply to all elderly patients or surgeries, and the drugs can cause side effects like slow heart rate or breathing problems.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Tian Jin First Center Hospital
Tianjin, China
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TianJin First Central Hospital
Tianjin, Tianjin Municipality, 300192, China