Can melatonin and a sedative stop brain surgery confusion?
NCT ID NCT07475156
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving melatonin along with the sedative dexmedetomidine could lower the chance of post-operative delirium (confusion) after open brain surgery. 100 adults aged 30-60 took part. The goal was to see if the combination works better than dexmedetomidine alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dexmedetomidine and melatonin
- What this could lead to
- If it works, this could point toward a simple way to reduce confusion and improve recovery after brain surgery.
- What could go wrong
- This is a small, completed Phase 4 trial with only 100 participants. Results may not apply to all patients, and the combination may not be more effective than dexmedetomidine alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faculty of Medicine , Ain Shams University
Cairo, Abbassia, 1181, Egypt