New pill could stop and treat dangerous swelling attacks

NCT ID NCT07266805

Recruiting now Disease control Sponsor: Pharvaris Netherlands B.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times

Summary

This Phase 3 trial tests an oral drug called deucrictibant in adults with acquired angioedema due to C1 inhibitor deficiency, a rare condition causing sudden, painful swelling attacks. The study has three parts: one to see if a daily extended-release tablet can prevent attacks, another to test an immediate-release capsule for on-demand treatment, and an open-label part for long-term safety. About 32 participants will be enrolled to compare the drug against placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deucrictibant
What this could lead to: If successful, this could provide a new oral option to prevent and treat swelling attacks in people with acquired angioedema, reducing the need for emergency care.
What could go wrong: This is a small Phase 3 trial with only 32 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acquired angioedema acquired angioedema with C1Inh deficiency angioedema hereditary angioedema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACQUIRED ANGIOEDEMA DUE TO C1-INHIBITOR DEFICIENCY (AAE-C1-INH)

Contacts and locations

Locations

Study Site
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San Diego, California, 92093, United States
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Walnut Creek, California, 94598,, United States
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St Louis, Missouri, 63130, United States
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Hershey, Pennsylvania, 17033, United States
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Clayton, Australia
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Vienna, Austria
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Sofia, Bulgaria
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Edmonton, Canada
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Grenoble, France
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Lille, France
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Paris, France
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Berlin, Germany
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Frankfurt am Main, Germany
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Munich, Germany
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Budapest, Hungary
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Padova, Italy
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Roma, Italy
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Amsterdam, Netherlands
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Auckland, New Zealand
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Krakow, Poland
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Madrid, Spain
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Basel, Switzerland
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Ankara, Turkey (Türkiye)
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Bristol, United Kingdom
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Cambridge, United Kingdom
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Leicester, United Kingdom
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London, United Kingdom
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Newcastle upon Tyne, United Kingdom
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Plymouth, United Kingdom
Study Site 1
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Milan, Italy
Study Site 2
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Milan, Italy
Study Site 3
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Milan, Italy