Could a One-Time cell therapy ease myasthenia gravis? new trial launches
NCT ID NCT06799247
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 study tests an experimental treatment called Descartes-08 for adults with generalized myasthenia gravis, a condition causing muscle weakness. The therapy uses modified immune cells (mRNA CAR T-cells) to target the disease. About 100 participants will receive either the treatment or a placebo, and researchers will measure improvements in daily activities over 4 months. Participants must be on stable immunosuppressive medications, meaning this is not a cure but aims to better control the disease.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A10
RECRUITINGTampa, Florida, 33612, United States
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A11
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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A12
RECRUITINGAmherst, New York, 14226, United States
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A13
RECRUITINGCarlsbad, California, 92011, United States
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A14
RECRUITINGOrange, California, 92868, United States
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A15
RECRUITINGPortland, Oregon, 97239, United States
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A16
RECRUITINGLexington, Kentucky, 40536, United States
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A17
RECRUITINGIstanbul, Turkey (Türkiye)
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A18
RECRUITINGToronto, Canada
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A20
RECRUITINGFairway, Kansas, 66205, United States
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A21
RECRUITINGAurora, Colorado, 80045, United States
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A22
RECRUITINGChapel Hill, North Carolina, 27599, United States
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A23
RECRUITINGRome, Italy
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A24
RECRUITINGBelgrade, Serbia
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A25
RECRUITINGBarcelona, Spain
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A26
RECRUITINGBarcelona, Spain
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A30
RECRUITINGKrakow, Poland
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A31
RECRUITINGMadrid, Spain
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A32
RECRUITINGAnkara, Turkey (Türkiye)
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A33
RECRUITINGBirmingham, United Kingdom
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A38
RECRUITINGBoston, Massachusetts, 02111, United States
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A39
RECRUITINGCharlotte, North Carolina, 28204, United States
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A40
RECRUITINGTucson, Arizona, 85718, United States
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A41
RECRUITINGSeattle, Washington, 98195, United States
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A43
RECRUITINGHouston, Texas, 77030, United States
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A46
RECRUITINGLos Angeles, California, 90095, United States
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A47
RECRUITINGNew York, New York, 10065, United States
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A48
RECRUITINGMaitland, Florida, 32751, United States
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A49
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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A50
RECRUITINGWashington D.C., District of Columbia, 20007, United States
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A51
RECRUITINGSheffield, United Kingdom
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A52
RECRUITINGNew York, New York, 10027, United States
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A53
RECRUITINGO'Fallon, Illinois, 62269, United States
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A54
RECRUITINGMilwaukee, Wisconsin, 53215, United States