A daily capsule that could turn back the clock on facial aging?

NCT ID NCT07790237

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

Researchers are testing whether a daily 60 mg dose of Dermial, a dietary supplement, can improve skin glow, hydration, and other signs of facial aging in healthy women aged 35 to 65. Over 12 weeks, half the participants will take Dermial and half will take a placebo, with neither they nor the researchers knowing who gets which. The main goal is to measure changes in facial skin gloss at the eye area, with additional checks on other facial zones. The trial aims to see if this supplement offers a safe, simple way to support skin radiance and reduce age-related changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dermial, a dietary supplement taken as one 60 mg capsule per day
What this could lead to
If it works, this could point toward a simple daily supplement that helps healthy women improve skin glow, hydration, and reduce visible signs of facial aging.
What could go wrong
This is an early-stage trial with a modest number of participants, and results may not apply to everyone. The supplement may also cause unexpected side effects, though it is a dietary product.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 146 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Willing and able to comply with all study requirements and restrictions, provide informed consent, understand and complete study questionnaires, and undergo all study-related procedures. * Healthy women aged 35 to 65 years (inclusive) presenting signs of physiological facial skin ageing, defined as Grade II (Expression Wrinkles) or Grade III (Wrinkles at Rest) according to the Glogau Scale, as assessed by the investigator. * Body mass index (BMI) between 18.0 and 34.9 kg/m² (inclusive). Willingness to maintain their usual cosmetic treatment routine throughout the study. * Willingness to refrain from undergoing any facial rejuvenation treatments during the study. * Willingness not to initiate nutritional supplements containing ingredients with potential skin-related effects during the study (e.g., hyaluronic acid, collagen, methylsulfonylmethane, vitamin C, soy, CoQ10, or antioxidants). * Willingness not to initiate the use of new topical products other than those included in their usual skincare routine during the study. * Willingness to maintain their normal lifestyle habits throughout the study (including sun exposure, diet, physical activity, and sleep habits). * Women willing not to initiate or modify estrogen- or progesterone-based therapies during the study. * Women willing to avoid pregnancy during the study by using appropriate contraceptive methods. * Women willing not to use any skin-firming, skin-lightening, topical, or systemic medication known to affect skin ageing or dyschromia during the study period. Exclusion Criteria: * Regular use of hyaluronic acid-containing creams within the 3 months prior to enrolment. * Regular use of oral supplements that may affect skin condition within the 3 months prior to enrolment. * Changes in facial or body cosmetic routines within 1 month prior to enrolment. * Use of medications affecting skin responses (e.g., glucocorticoids, antihistamines, immunomodulators). * Presence of skin pigmentation disorders. * Chronic sun exposure or planned use of tanning beds within 1 month prior to enrolment or during the study. * Facial rejuvenation treatments (e.g., microneedling, needle mesotherapy, medium/deep chemical peels, ablative laser treatments, electrotherapy, intense pulsed light therapy) within the 4 months prior to enrolment. * Self-reported allergy to cosmetic products and/or sunscreens. * Use of hormonal contraceptives for less than 3 months before enrolment, or a change in contraceptive method within the 3 months prior to enrolment in women of childbearing potential. * Employees of clinical laboratories, testing companies, cosmetic manufacturers, suppliers of topical product raw materials, or related industries. * Pregnant, breastfeeding, or planning to become pregnant during the study. * Known hypersensitivity, intolerance, or allergy to any study product, excipient, or rescue medication. * Presence of inflammatory facial skin disorders at enrolment, including psoriasis, atopic dermatitis, rosacea, acne, or hidradenitis suppurativa. * Type 1 diabetes, uncontrolled type 2 diabetes, uncontrolled hypertension (≥140 mmHg systolic or ≥90 mmHg diastolic), or uncontrolled thyroid disease. * Known diseases interfering with absorption, distribution, metabolism, or excretion of the study product (e.g., Crohn's disease, short bowel syndrome, acute or chronic pancreatitis, pancreatic insufficiency). * History of cardiovascular disease, kidney disease (including dialysis or renal failure), liver disease, immune disorders, or immunocompromised conditions (e.g., HIV/AIDS). * History of cancer (except localized non-metastatic skin cancer or cervical carcinoma in situ) with recovery occurring within 5 years prior to enrolment. * Severe psychiatric disorders (e.g., depression, bipolar disorder, schizophrenia) or psychiatric hospitalization within 12 months prior to enrolment. * Clinically significant illness reported within 28 days prior to enrolment. * Major surgery within the 3 months prior to enrolment or planned during the study. * History of alcohol or substance abuse within 12 months prior to enrolment, including hospitalization for intervention programs, or any use considered by the investigator to pose a study risk. * Current participation or participation within the previous 2 months in another clinical study involving an investigational product, or prior investigational products with residual effects that may affect eligibility or study outcomes. * Any medical condition, clinical situation, medication, supplement, or therapy that, in the investigator's opinion, may interfere with study participation, study assessments, participant safety, or study integrity. * Treatment with Botulinum toxin (Botox®), hyaluronic acid fillers, or platelet-rich plasma (PRP) within the 6 months prior to enrolment, or collagen biostimulators within the 12 months prior to enrolment. * Participants who have undergone: Superficial or medium-depth chemical peels, or dermabrasion, within 6 weeks prior to enrolment. Facial plastic surgery or ablative laser treatment for photoageing within 12 months prior to enrolment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Institute of Advanced Medicine and Dermatology (IMDA)

    Madrid, Madrid, 28001, Spain

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