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Can natural growth factors make dental implants heal faster and stronger?

NCT ID NCT07675772

Disease control Sponsor: Sana'a University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether adding concentrated growth factor (CGF) or advanced platelet-rich fibrin (A-PRF) to short dental implant surgery improves wound healing and implant stability. The trial involves 72 adults aged 18-45 with missing premolar or molar teeth and adequate bone. Participants receive delayed short dental implants with immediate loading, with or without these growth factors, and are monitored for gum health, bone changes, and implant stability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF)
What this could lead to
If successful, this approach could improve dental implant healing and stability, reducing complications and improving outcomes for patients with limited bone height.
What could go wrong
This is a small, early-stage trial. The benefits of CGF and A-PRF for dental implants are not yet proven, and results may not apply to all patients or implant types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- • Patient aged 18 - 45 years old. • Patients maintaining excellent oral hygiene standards. • Systemically healthy patient. • Single or multiple missing teeth in premolar and molar region. • Patients should have adequate bone width volume (\>4 mm) and bone density with sufficient mesiodistal and interocclusal space. Bone height (≤10mm). • The patient should physically and psychologically be able to tolerate short implant surgical procedure. • Patient with a sufficient platelet count (\>200,000/mm3) for CGF and A-PRF preparation. • Patients who provided informed consent. Exclusion Criteria: * \> Presence of active periodontal disease. Patients with a significant medical history which contradicts placement of dental implants such as: • Diabetes. • Diseases affecting bone metabolism. • Patients currently on antibiotics, steroids, hormonal therapy, or medications known to affect bone metabolism. • Patients with a history of radiotherapy or chemotherapy, coagulation defects, or currently on anticoagulant treatment. • Pregnant or lactating women. • Patients with poor oral hygiene. • Habits such as khat chewing, smoking and alcohol intake. • Insufficient vertical interarch space. • Temporomandibular joint disorder. • Parafunctional habits.

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As listed by the trial registrant

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Dent implants

How to take part

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  1. The official record

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