Can a Patient's own immune cells fight ovarian cancer?

NCT ID NCT04614051

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers test a personalized cancer immunotherapy called Cellgram-DC in people with advanced or recurrent epithelial ovarian cancer. The treatment uses a patient's own dendritic cells, a type of immune cell, to try to trigger an immune response against the tumor. Participants receive three injections near the lymph nodes in the armpit every two weeks. The trial primarily checks safety and side effects, while also looking at immune markers and tumor response.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
autologous dendritic cell immunotherapy (Cellgram-DC)
What this could lead to
If it works, this could point toward a new immunotherapy option for ovarian cancer that uses a patient's own immune cells.
What could go wrong
This is a very early phase 1 trial with only 2 participants, so it mainly checks safety and cannot show whether the treatment works. The approach may not shrink tumors or help beyond standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

2 people

The number who actually took part.

Started

Feb 2022

Finished

Jul 2022

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 79 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 19 and under 80 years 2. Patients with Fédération Internationale de Gynécologie et d' Obstétrique(FIGO) stage III with histologically confirmed advanced or recurrent epithelial ovarian cancer (Serous, endometrioid, and mucinous only), fallopian tube cancer, and primary peritoneal cancer (residual tumor size \<1cm) 3. Patients who have undergone tumor reduction or staging and complete or plan to complete platinum-based chemotherapy 4. In case of complete or partial response in primary or secondary chemotherapy 5. Whole body performance status: European Cooperative Oncology Group(ECOG) 0\~1 6. Patients whose BRCA gene mutation test results can be confirmed 7. Patients whose life expectancy is at least 6 months or longer 8. Hb ≥ 8.0 g/dL, Absolute Neutrophil Count(ANC) ≥ 1,500/mm3, Platelets ≥ 100,000/mm3 9. Serum Creatinine ≤ 1.5 x Upper Limit of Normal(ULN) or Serum Creatinine\> 1.5 x ULN and Calculated Creatinine Clearance\> 30 mL/min 10. Total Bilirubin ≤ 1.5 x ULN or Direct bilirubin ≤ ULN, Aminotransferase (AST)/Alanine aminotransferase(ALT) \<2.5 x ULN 11. Patients who did not receive surgery, radiation therapy, or immunotherapy within the last 6 weeks and recovered from side effects 12. Patients who agreed to use a medically recognized contraceptive method (diaphragm method used with spermicide, abstinence) during participation in the clinical trial (injection or implantable hormone therapy is not appropriate). 13. Patients who voluntarily participated in clinical trials and signed the Informed Contents Form (ICF) Exclusion Criteria: 1. Patients with malignant tumors other than non-melanoma skin cancer in the past 3 years 2. Patients with brain metastases 3. Patients who previously received anti-tumor immunotherapy (anti-PD1, anti-PDL1 or anti-PDL2, etc.) or participated in immunotherapy-related clinical trials 4. Patients with active autoimmune diseases requiring systemic immunosuppression treatment (e.g., immunosuppressants such as cyclosporin A or azathioprine, or steroids for disease control) 5. Patients who use or plan to use Poly (ADP-ribose) polymerase (PARP) inhibitors due to the confirmed Breast Cancer Susceptibility Gene(BRCA) 1 or BRCA 2 mutation 6. Patients with medical conditions requiring continuous or intermittent administration of systemic steroids or immunosuppressants 7. Patients who received blood products (limited to whole blood products) within 4 weeks of screening criteria, or patients who received colony stimulating factors (Colony Stimulating Factor or recombinant Erythropoietin) 8. Patients with a history of organ or hematopoietic stem cell transplantation 9. Patients with acute or chronic infections requiring systemic treatment 10. Patients known to be infected with human immunodeficiency virus (HIV)/serum positive 11. Patients with active hepatitis A, B or C 12. Patients with untreated syphilis 13. Patients expected to need systemic chemotherapy, biotherapy, or immunotherapy for therapeutic purposes 14. Patients who received live virus vaccines (e.g. measles, mumps, rubella, chickenpox, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), oral typhoid vaccine, Flu-Mist, etc.) within 30 days 15. Patients with a history of anaphylaxis to gentamicin 16. Pregnant or breastfeeding patients 17. Others, if the person in charge of the study determines that it is not suitable for the clinical trial

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Asan medical center

    Seoul, South Korea

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