Could a single IV dose stop the bends? new trial tests Rhu-pGSN
NCT ID NCT06216366
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 37 times
Summary
This study tests whether an experimental drug called rhu-pGSN can reduce inflammation caused by decompression sickness (the bends) in divers. Thirty-six healthy, trained divers will be exposed to high pressure in a hyperbaric chamber, simulating a dive to 30 meters. They will receive either the drug or a placebo before or after the exposure. Researchers will measure inflammatory markers in the blood and check for gas bubbles to see if the drug helps.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of Maryland School of Medicine
Baltimore, Maryland, 21201, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
recombinant human plasma gelsolin (rhu-pGSN)
What this could lead to
If it works, this could lead to a new treatment to prevent or reduce the harmful effects of decompression sickness in divers.
What could go wrong
This is a small, early-phase trial in healthy volunteers, not real diving accidents. The drug may not work as hoped or could have side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.