New drug shows promise for rare Muscle-Weakening diseases
NCT ID NCT05895786
First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 22 times
Summary
This study tests a new medicine called dazukibart (PF-06823859) for people with active dermatomyositis or polymyositis, rare diseases that cause muscle inflammation, weakness, and sometimes skin rash. About 318 adults will receive either the drug or a placebo as an IV infusion every 4 weeks for 48 weeks, while continuing their usual medications. The goal is to see if dazukibart safely improves muscle strength and daily function.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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5 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ
RECRUITINGKrakow, Lesser Poland Voivodeship, 30-901, Poland
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Ajou University Hospital
RECRUITINGSuwon, Kyǒnggi-do, 16499, South Korea
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Anhui Provincial Hospital
RECRUITINGHefei, Anhui, 230001, China
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Ankara University Ibni Sina Hospital
RECRUITINGAnkara, 06230, Turkey (Türkiye)
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Azienda Ospedaliera Universitaria Careggi
RECRUITINGFlorence, 50139, Italy
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Azienda Ospedaliero Universitaria Policlinico G.Rodolico-San Marco Di Catania
RECRUITINGCatania, 95121, Italy
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Boca Clinical Trials Mexico S.C.
NOT_YET_RECRUITINGGuadajalara, Jalisco, 44600, Mexico
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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CER medical Institute
RECRUITINGQuilmes, Buenos Aires F.D., B1878, Argentina
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CHARM HEALTHCARE PRIVATE LIMITED (Previously Dr Shenoy's Care Private Limited)
RECRUITINGKochi, Kerala, 682040, India
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CITER Centro de Investigacion y Tratamiento de las Enfermedades Reumáticas S.A. de C.V.
NOT_YET_RECRUITINGMexico City, 06700, Mexico
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CITER Centro de Investigación y Tratamiento de las Enfermedades Reumáticas
NOT_YET_RECRUITINGMexico City, Mexico City, 06700, Mexico
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Center for Clinical Research - Chapman Pavilion
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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Centrum Medyczne Plejady
RECRUITINGKrakow, Lesser Poland Voivodeship, 30-363, Poland
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China-Japan Friendship Hospital
RECRUITINGBeijing, Beijing Municipality, 100029, China
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Chonnam National University Bitgoeul Hospital
RECRUITINGGwangju, Kwangju-kwangyokshi, 61748, South Korea
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Cryptex Investigación Clínica S.A. de C.V.
RECRUITINGCuauhtémoc, Mexico City, 06100, Mexico
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First Affiliated Hospital of Kunming Medical University
RECRUITINGKunming, Yunnan, 650032, China
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Hacettepe Universite Hastaneleri
RECRUITINGAnkara, 06230, Turkey (Türkiye)
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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Hospital Universitario Infanta Leonor
RECRUITINGMadrid, Madrid, Comunidad de, 28031, Spain
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Hospital Universitario de Canarias
RECRUITINGSan Cristóbal de La Laguna, Santa CRUZ DE Tenerife, 38320, Spain
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Hospital for Special Surgery
NOT_YET_RECRUITINGNew York, New York, 10021, United States
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Hospital of the university of occupational and environmental health
RECRUITINGKitakyushu-shi, Fukuoka, 807-8556, Japan
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Huashan Hospital, Fudan University
RECRUITINGShanghai, Shanghai Municipality, 200040, China
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Hôpital Edouard Herriot
NOT_YET_RECRUITINGLyon, 69003, France
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Hôpitaux Universitaires Pitie Salpetriere AP-HP - CRMR des Myopathies Inflammatoires
NOT_YET_RECRUITINGParis, 75013, France
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IRCCS Istituto Clinico Humanitas
RECRUITINGRozzano, Milano, 20089, Italy
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Institute of Science Tokyo Hospital
RECRUITINGBunkyo-ku, Tokyo, 113-8519, Japan
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Instituto de Investigaciones Clinicas Zarate
NOT_YET_RECRUITINGZárate, Buenos Aires, B2800DGH, Argentina
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Instituto de Reumatología Medical Center S.A.
RECRUITINGMendoza, 5500, Argentina
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Lal Bhagchandani, M.D
ACTIVE_NOT_RECRUITINGMargate, Florida, 33063, United States
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Mayo Clinic Hospital
RECRUITINGPhoenix, Arizona, 85054, United States
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Medical Center Artmed
RECRUITINGPlovdiv, 4002, Bulgaria
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Memorial Ankara Hastanesi
RECRUITINGAnkara, 06520, Turkey (Türkiye)
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NYU Langone Health
RECRUITINGNew York, New York, 10016, United States
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NYU Langone Health Clinical Research Center
RECRUITINGNew York, New York, 10016, United States
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NYU Langone Radiology
RECRUITINGNew York, New York, 10016, United States
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
RECRUITINGNanjing, Jiangsu, 210000, China
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Narodny ustav reumatickych chorob
RECRUITINGPiešťany, 921 12, Slovakia
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National Hospital Organization Osaka Minami Medical Center
RECRUITINGKawachi-Nagano, Osaka, 586-8521, Japan
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National Taiwan University Hospital
RECRUITINGTaipei, 100225, Taiwan
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Nerve & Muscle Center of Texas
RECRUITINGHouston, Texas, 77030, United States
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Nippon Medical School Hospital
RECRUITINGBunkyo-ku, Tokyo, 113-8603, Japan
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Peking Union Medical College Hospital
RECRUITINGBeijing, Beijing Municipality, 100730, China
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Pécsi Tudományegyetem Klinikai Központ
RECRUITINGPécs, Baranya, 7632, Hungary
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, 250012, China
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Ruijin Hospital Shanghai Jiaotong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, 200025, China
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Salford Royal Hospital
RECRUITINGSalford, Manchester, M6 8HD, United Kingdom
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Shanghai Jiaotong University School of Medicine, Renji Hospital
RECRUITINGShanghai, Shanghai Municipality, 200001, China
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Shanghai Jiaotong University School of Medicine, Renji Hospital
RECRUITINGShanghai, Shanghai Municipality, 200127, China
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Shiga University of Medical Science Hospital
RECRUITINGŌtsu, Shiga, 520-2192, Japan
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Sourasky Medical Center
RECRUITINGTel Aviv, TELL ABĪB, 6423906, Israel
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Tianjin Medical University General Hospital
RECRUITINGTianjin, Tianjin Municipality, 300052, China
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Tohoku University Hospital
RECRUITINGSendai, Miyagi, 980-8574, Japan
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Tokyo Medical University Hospital
RECRUITINGShinjuku-ku, Tokyo, 160-0023, Japan
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UCI Douglas Hospital
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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UCI Health Center for Innovative Health Therapies
ACTIVE_NOT_RECRUITINGOrange, California, 92868, United States
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UCLA Clinical & Translational Research Center (CTRC)
RECRUITINGLos Angeles, California, 90095, United States
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University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Medical Center - Hoglund Brain Imaging Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Miami
RECRUITINGMiami, Florida, 33125, United States
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Wakayama Medical University Hospital
RECRUITINGWakayama, 641-8510, Japan
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West Broward Rheumatology Associates
ACTIVE_NOT_RECRUITINGTamarac, Florida, 33321, United States
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Yamaguchi University Hospital
RECRUITINGUbe, Yamaguchi, 755-8505, Japan
Conditions
Explore the condition pages connected to this study.