New drug duo aims to slow advanced lung cancer
NCT ID NCT05215340
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tests whether adding the drug Dato-DXd to standard immunotherapy (pembrolizumab) helps people with advanced or metastatic non-small cell lung cancer live longer without their cancer growing. About 740 adults with a high level of a protein called PD-L1 will be randomly assigned to get the combo or pembrolizumab alone. The study compares how long it takes for the cancer to progress and overall survival.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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A.O. Perugia Santa Maria della Misericordia
Perugia, 06132, Italy
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AP-HP - Hopital Tenon
Paris, 75970, France
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APHM - Hopital Nord
Marseille, 13015, France
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AZ Nikolaas
Sint-Niklaas, 9100, Belgium
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Adana Acibadem Hospital
Adana, 1130, Turkey (Türkiye)
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Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guangzhou, 510095, China
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Akdeniz University Hospital
Antalya, 7070, Turkey (Türkiye)
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American Oncology Partners of Maryland
Bethesda, Maryland, 20817, United States
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Amsterdam Umc, Location Vumc
Amsterdam, 1081 HZ, Netherlands
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Aomori Prefectural Central Hospital
Aomori, Aomori, 030-8553, Japan
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Arizona Oncology NAHOA
Irving, Texas, 75063, United States
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Army Medical Center of PLA
Chongqing, 400042, China
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Asan Medical Center
Songpa-gu, 5505, South Korea
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Asst Sette Laghi Ospedale di Circolo e Fondazione Macchi
Varese, 21100, Italy
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Astera Cancer Care
East Brunswick, New Jersey, 08816, United States
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Austin Hospital
Heidelberg, Victoria, 3084, Australia
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Az Maria Middelares - Campus Maria Middelares
Ghent, 9000, Belgium
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Azienda Ospedaliera dei Colli
Naples, 80131, Italy
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Bioclinic Thessaloniki
Thessaloniki, 54622, Greece
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Birmingham Heartlands Hospital
Birmingham, B9 5SS, United Kingdom
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Bkmk Hospital
KecskemĂŠt, 6000, Hungary
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Bordeaux University Hospital - Hopital Saint Andre
Bordeaux, 33075, France
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CER SAN JUAN - Centro Polivalente de Asistencia e Investigación Clínica
San Juan, 5400, Argentina
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CHU de Nantes
Nantes, 44093, France
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CHU de Poitier Pole Regional de Cancerologie
Poitiers, 86000, France
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CHUO
Ourense, 32005, Spain
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Cancer Care Center of Brevard
Irving, Texas, 75063, United States
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Cangzhou People's Hospital
Cangzhou, 610001, China
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Centre Hospitalier Universitaire de Lille
Lille, 59000, France
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Centre Hospitalier Universitaire de Montpellier
Montpellier, 34295, France
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Centre Leon Berard
Lyon, 69008, France
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Centro Clinico Champalimau
Lisbon, 1400-038, Portugal
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Centro Hospitalar Universitário de São João
Porto, 4200-319, Portugal
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Centro Hospitalar e Universitário do Porto
Porto, 4099-001, Portugal
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Centro de Estudios Clínicos SAGA
Santiago, Santiago Metropolitan, 7500653, Chile
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Centro de Estudos e Pesquisa de Hematologia e Oncologia - CEPHO
Santo André, 09060-870, Brazil
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Centro de Investigacion Clinica de Oaxaca (CICLO)
Oaxaca City, 68020, Mexico
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Centro de Investigaciones Clinicas Vina Del Mar
Viña del Mar, 254-0488, Chile
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Centro de Investigaciones Medicas y Desarrollo LC S.R.L. (LC Investigacion)
Buenos Aires, Argentina
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Centro de Investigación Pergamino S. A.
Pergamino, 2700, Argentina
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Centrul de Oncologie Sf Nectarie S.R.L.
Craiova, 200542, Romania
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Chang Gung Memorial Hospital Cgmh - Kaohsiung Branch
Kaohsiung City, 833, Taiwan
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Chang Gung Memorial Hospital LinKou
Taoyuan, 333, Taiwan
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Chris Obrien Lifehouse
Camperdown, 2050, Australia
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Chung Shan Medical University Hospital
Taichung, 40201, Taiwan
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Chungbuk National University Hospital
Cheongju-si, North Chungcheong, 28644, South Korea
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Clinica Viedma SA
Viedma, 8500, Argentina
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Clínica de Neoplasias Litoral
Itajaí, 88301-220, Brazil
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Cooperman Barnabas Medical Center
New Brunswick, New Jersey, 08901, United States
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Cryptex Investigacion Clinica Sa de Cv
Cuauhtémoc, 06100, Mexico
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DFCI - South Shore Hospital
South Weymouth, Massachusetts, 02190, United States
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Dana Farber Cancer Institute - Foxborough
Foxborough, Massachusetts, 02035, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03766, United States
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Dokkyo Medical University Hospital
Shimotsuga-gun, Tochigi, 321-0293, Japan
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Dom Lekarski SA
Szczecin, West Pomeranian Voivodeship, 70-784, Poland
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E-Da Hospital
Kaohsiung City, 824, Taiwan
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Ege University
Bornova-İzmir, 35100, Turkey (Türkiye)
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Evangelische Lungenklinik Berlin
Berlin, 13125, Germany
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Faculty of Medicine Chulalongkorn University
Bangkok, 10330, Thailand
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Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
Székesfehérvár, 8000, Hungary
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Fudan University Shanghai Cancer Center
Shanghai Shi, 200032, China
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Fundacion CENIT para la investigación en Neurociencias
Ciudad Autonoma de Buenos Aire, 1125, Argentina
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Fundación Arturo Pérez López
Santiago, 7500921, Chile
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Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul, 34772, Turkey (Türkiye)
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Grand Hopital de Charleroi - Hopital Saint Joseph
Charleroi, 6000, Belgium
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Guangxi Medical University Affiliated Tumor Hospital
Nanning, Guangxi, 530021, China
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Gyeongsang National University Hospital
Jinju, Gyeongsangnam-do, 52727, South Korea
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Haikou People's Hospital
Haikou, 570208, China
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Harbin Medical University Cancer Hospital
Harbin, 150081, China
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Henan Cancer Hospital
Zhengzhou, Henan, 450008, China
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Hopital FOCH
Suresnes, 92150, France
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Hopital prive du Confluent
Nantes, 44277, France
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Hospital CUF Porto
Porto, 4100-180, Portugal
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Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara, 44280, Mexico
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Hospital Clinic i Provincial de Barcelona
Barcelona, 08036, Spain
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Hospital Clinico San Carlos
Madrid, 28040, Spain
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Hospital Erasto Gaertner
Curitiba, 81520-060, Brazil
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Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
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Hospital Privado de la Comunidad
Mar del Plata, B7602CBM, Argentina
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Hospital Regional Universitario Malaga
Málaga, 29010, Spain
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Hospital Universitari Vall D'Hebron
Barcelona, 8035, Spain
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Hospital Universitari i Politècnic La Fe
Valencia, 46026, Spain
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Hospital Universitario Arnau de Vilanova - Lleida
Lleida, 25198, Spain
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Hospital Universitario Dr. Jose Eleuterio Gonzalez
Monterrey, 64460, Mexico
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Hospital Universitario de Valme
Seville, 41014, Spain
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Hubei Cancer Hospital
Wuhan, 430079, China
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Hunan Cancer Hospital
Changsha, 410013, China
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II Klinika Chorob Pluc I Gruzlicy
Bialystok, 15-450, Poland
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IRCCS Istituto Oncologico Giovanni Paolo II
Bari, 70124, Italy
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IRCCS Ospedale San Raffaele
Milan, 20132, Italy
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Ifo Regina Elena
Rome, 144, Italy
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Illinois Cancer Specialists
Irving, Texas, 75063, United States
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Inner Mongolia Medical University- the Affiliated Hospital
Hohhot, 10050, China
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Institut Bergonie
Bordeaux, 33076, France
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Institut Paoli-Calmettes
Marseille, 13273, France
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Instituto Nacional de Câncer - INCA
Rio de Janeiro, 20231-050, Brazil
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Instituto Portuguas de Oncologia do Porto Francisco Gentil
Porto, 4200-072, Portugal
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Instituto de Ensino e Pesquisas Sao Lucas
São Paulo, 01236-030, Brazil
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Instituto de Oncología de Rosario
Rosario, S2000, Argentina
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Instituto de Pesquisas em Saúde - IPS
Caxias do Sul, 95020-972, Brazil
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Instituto do Cancer Brasil - Unidade Taubate
Taubaté, Brazil
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Instytut Centrum Zdrowia Matki Polki
Lodz, Iodzkie, 93-338, Poland
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Irccs Istituto Europeo Di Oncologia
Milan, 20141, Italy
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Ironwood Cancer and Research Center
Chandler, Arizona, 85224, United States
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Jeroen Bosch Ziekenhuis J BZ Hieronymus Bosch Hospital
's-Hertogenbosch, 5223 GZ, Netherlands
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Jiamusi Tumor and Tuberculosis Hospital
Jiamusi, 154007, China
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Jiangsu Province Hospital
Nanjing, 210029, China
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Jilin Cancer Hospital
Changchun, Jilin, 130012, China
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Johns Hopkins University
Baltimore, Maryland, 21205, United States
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Juntendo University Hospital
Bunkyo-ku, Tokyo, 113-8431, Japan
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Kanagawa Cancer Center
Yokohama, Kanagawa, 241-8515, Japan
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Kanazawa University Hospital
Kanazawa, Ishikawa-ken, 920-8641, Japan
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Kansai Medical University Hospital
Hirakata-shi, Osaka, 573-1191, Japan
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Kantonsspital Baden
Baden, 5404, Switzerland
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Kantonsspital Baselland
Liestal, A4410, Switzerland
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Kantonsspital St. Gallen
Sankt Gallen, Switzerland
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Karl-Landsteiner Institute for Lung Research and Pulmonary Oncology c/o Klinik Floridsdorf
Vienna, 1090, Austria
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Klinikum Esslingen GmbH
Esslingen am Neckar, 73730, Germany
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Klinikum Klagenfurt am Wörthersee Abteilung für Lungenkrankheiten
Klagenfurt, Austria
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Klinikum der Universitaet Muenchen
München, 80336, Germany
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Koo Foundation Sun Yat-Sen Cancer Center
Taipei, 112, Taiwan
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Kurume University Hospital
Kurume-shi, Fukuoka, 830-0011, Japan
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Kyungpook National University Chilgok Hospital
Daegu, 42119, South Korea
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Kyushu University Hospital
Fukuoka, Fukuoka, 812-8582, Japan
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Leiden University Medical Center
Leiden, 2333 ZA, Netherlands
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Liaoning Cancer Hospital& Institute
Shenyang, 110801, China
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Linyi Cancer Hospital
Linyi, 276000, China
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LungenClinic Grosshansdorf
Großhansdorf, 22927, Germany
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MS Pneumed Janusz Milanowski, Katarzyna Szmygin-Milanowska Sp. Jawna
Lublin, 20-064, Poland
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Maryland Oncology Hematology
Irving, Texas, 75063, United States
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Matsusaka Municipal Hospital
Matsusaka-shi, Mie-ken, 515-8544, Japan
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McGill University Health Centre
Montreal, H4A 3J2, Canada
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Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Medical Park Seyhan Hospital
Seyhan /Adana, 1140, Turkey (Türkiye)
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Memorial Ankara Hospital Ankara
Çankaya, 06520, Turkey (Türkiye)
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Metropolitan Hospital
Neo Faliro, Athens, 14564, Greece
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Metropolitan Hospital
Neo Faliro, 18547, Greece
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Metropolitan Hospital
Piraeus, 18547, Greece
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Montefiore Medical Center
The Bronx, New York, 10461, United States
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NHO Iwakuni Clinical Center
Iwakuni-shi, Yamaguchi, 740-8510, Japan
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NHO Kinki-Chuo Chest Medical Center
Sakai-shi, Osaka, 591-8555, Japan
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NHO Shikoku Cancer Center
Matsuyama, Ehime, 791-0280, Japan
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National Cancer Center
Goyang-si, 10408, South Korea
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National Cancer Center Hospital East
Kashiwa-shi, Chiba, 277-8577, Japan
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National Cheng Kung University Hospital Nckuh
Tainan, 704, Taiwan
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National Hospital Organization Kyushu Cancer Center
Fukuoka, Fukuoka, 811-1395, Japan
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National Taiwan University Hospital
Taipei, 100, Taiwan
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Niigata Cancer Center Hospital
Niigata, Niigata, 961-8566, Japan
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Nottingham University Hospitals
Nottingham, NG5 1PB, United Kingdom
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Onco Clinic Consult SA
Craiova, 200094, Romania
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Oncocenter-Oncologie Clinica SRL
Timișoara, 300166, Romania
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Oncologico Potosino
San Luis Potosí City, 78209, Mexico
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Oncosite - Centro de Pesquisa Clinica Oncologia
Ijuí, 98700-000, Brazil
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Oncovida
Santiago, 7500000, Chile
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Onze-Lieve-Vrouwziekenhuis Olvz - Campus Aalst
Aalst, 9300, Belgium
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Orlandi Oncología
Santiago, 7501010, Chile
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Osaka International Cancer Institute
Osaka, Osaka, 541-8567, Japan
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Osaka Toneyama Medical Center
Osaka, 560-8552, Japan
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Ospedale San Luca
Lucca, 55100, Italy
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PIH Health Whittier Hospital
Whittier, California, 90602, United States
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Peking University Cancer Hospital
Beijing, 100142, China
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Peking University Peoples Hospital
Beijing, 100044, China
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Peninsula and South Eastern Haematology and Oncology Group
Mount Waverley, Victoria, 3149, Australia
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Policlinico Tor Vergata
Rome, 133, Italy
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Prince of Songkla University PSU - Faculty of Medicine
Hat Yai, Changwat Songkhla, 90110, Thailand
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Prince of Wales Hospital / The Chinese University of Hong Kong 99999
Hong Kong, 99999, Hong Kong
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Providence Regional Cancer System
Lacey, Washington, 98503, United States
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Pulmonology Hospital Torokbalint
Törökbálint, 2045, Hungary
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Queen Elizabeth Hospital
Hong Kong, Hong Kong
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Queen Mary Hospital
Pok Fu Lam, 999077, Hong Kong
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Regional Cancer Care Associates LLC
Freehold, New Jersey, 07728, United States
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Ridley-Tree Cancer Center
Santa Barbara, California, 93105, United States
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Rijnstate Ziekenhuis
Arnhem, Gelderland, 6815 AD, Netherlands
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SC Oncomed SRL
Timișoara, 300239, Romania
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Sainte-Catherine Institut du Cancer Avignon-Provence (ICAP)
Avignon, 84000, France
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Saiseikai Kumamoto Hospital
Kumamoto, Kumamoto, 861- 4193, Japan
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Samsung Medical Center
Seoul, 6351, South Korea
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Sanatorio Británico de Rosario
Rosario, S2002, Argentina
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Sanatorio Parque
Rosario, S2001, Argentina
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Santa Casa de Misericordia de Porto Alegre
Porto Alegre, 90050-170, Brazil
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Sc Sigmedical Services Srl
Suceava, 720214, Romania
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Semmelweis University Department of Pulmonology
Budapest, 1083, Hungary
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Sendai Kousei Hospital
Sendai, Miyagi, 980-0873, Japan
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Shanghai Pulmonary Hospital
Shanghai, 200433, China
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Sichuan Cancer Hospital
Chengdu, Sichuan, 610049, China
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Siriraj Hospital
Bangkok, 10700, Thailand
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Sotiria General Hosptial of Chest Diseases
Athens, 11527, Greece
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Southern Cancer Center
Irving, Texas, 75063, United States
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Srinagarind Hospital
Muaeng, Changwat Khon Kaen, 40002, Thailand
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St. Luke's Hospital
Thessaloniki, 55236, Greece
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Szpitale Pomorskie Sp. z o.o.
Gdynia, Pomeranian Voivodeship, 81-519, Poland
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Taichung Veterans General Hospital
Taichung, 40705, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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Teine Keijinkai Hospital
Sapporo, 006-8555, Japan
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Texas Oncology - Northeast Texas
Irving, Texas, 75063, United States
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Texas Oncology Gulf Coast
Irving, Texas, 75063, United States
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Texas Oncology McAllen
Irving, Texas, 75063, United States
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The Cancer Institute Hospital of JFCR
Kōtoku, Toyko, 135-8550, Japan
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The Catholic Univ. of Korea, Seoul St. Mary'S Hospital
Seoul, 6591, South Korea
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The First Affiliate Hospitalof Xi'An Jiaotong University
Xi'an, 710061, China
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The First Affiliated Hospital Xiamen University
Xiamen, 361001, China
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The First Affiliated Hospital of College of Medicine Zhejiang University
Hanghzou, 310003, China
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The First Affiliated Hospital of Nanchang University
Nanchang, 330006, China
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The First Hospital of China Medical University
Shenyang, 110001, China
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The Oncology Institute of Hope and Innovation
Whittier, California, 90603, United States
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The Queen Elizabeth Hospital
Woodville South, 5011, Australia
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The Second People's Hospital of Neijiang
Neijiang, 641000, China
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The Valley Hospital
Paramus, New Jersey, 07652, United States
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Tianjin Medical University General Hospital
Tianjin, 300052, China
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Toho University Omori Medical Center
Ōta-ku, Toyko, 143-8541, Japan
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Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Bunkyō-Ku, Tokyo, 113-8677, Japan
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UCLA HemOnc - Clinical Research Unit
Los Angeles, California, 90095, United States
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UOC Oncologia
Chieti, 66100, Italy
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UPCO - Unidade de Pesquisas Clínicas em Oncologia - Clinica Lacks
Pelotas, 96020-080, Brazil
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Uch-Mhs D/B/A Memorial Health System
Colorado Springs, Colorado, 80909, United States
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Union Hospital Affiliated With Tongji Medical College Huazhong University of Science and Technology
Wuhan, 430022, China
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University Hospital Basel
Basel, 4031, Switzerland
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University Hospital Kyoto Prefectural University of Medicine
Kyoto, 602-8566, Japan
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University Hospital of Ioannina Uhi
Ioannina, 45500, Greece
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University of Texas Health Science Center San Antonio
San Antonio, Texas, 78229, United States
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Utah Cancer Specialists
Salt Lake City, Utah, 84106, United States
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VA Puget Sound Health Care System - VAPSHCS
Seattle, Washington, 98108, United States
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Veszprem Megyei Tudogyogyintezet Farkasgyepu
Farkasgyepű, 8582, Hungary
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Xiangyang Central Hospital- 5 Lumen Avenue
Xiangyang, 441000, China
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Xinjiang Tumor Hospital
Ürümqi, 830000, China
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Yamaguchi-Ube Medical Center
Ube-shi, Yamaguchi, 755-0241, Japan
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Yamanashi Prefectural Central Hospital
Kofu, Japan
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Yunnan Cancer Hospital
Kunming, 650118, China