New drug duo aims to slow advanced lung cancer

NCT ID NCT05215340

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether adding the drug Dato-DXd to standard immunotherapy (pembrolizumab) helps people with advanced or metastatic non-small cell lung cancer live longer without their cancer growing. About 740 adults with a high level of a protein called PD-L1 will be randomly assigned to get the combo or pembrolizumab alone. The study compares how long it takes for the cancer to progress and overall survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A.O. Perugia Santa Maria della Misericordia

    Perugia, 06132, Italy

  • AP-HP - Hopital Tenon

    Paris, 75970, France

  • APHM - Hopital Nord

    Marseille, 13015, France

  • AZ Nikolaas

    Sint-Niklaas, 9100, Belgium

  • Adana Acibadem Hospital

    Adana, 1130, Turkey (Türkiye)

  • Affiliated Cancer Hospital and Institute of Guangzhou Medical University

    Guangzhou, 510095, China

  • Akdeniz University Hospital

    Antalya, 7070, Turkey (Türkiye)

  • American Oncology Partners of Maryland

    Bethesda, Maryland, 20817, United States

  • Amsterdam Umc, Location Vumc

    Amsterdam, 1081 HZ, Netherlands

  • Aomori Prefectural Central Hospital

    Aomori, Aomori, 030-8553, Japan

  • Arizona Oncology NAHOA

    Irving, Texas, 75063, United States

  • Army Medical Center of PLA

    Chongqing, 400042, China

  • Asan Medical Center

    Songpa-gu, 5505, South Korea

  • Asst Sette Laghi Ospedale di Circolo e Fondazione Macchi

    Varese, 21100, Italy

  • Astera Cancer Care

    East Brunswick, New Jersey, 08816, United States

  • Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Az Maria Middelares - Campus Maria Middelares

    Ghent, 9000, Belgium

  • Azienda Ospedaliera dei Colli

    Naples, 80131, Italy

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Bioclinic Thessaloniki

    Thessaloniki, 54622, Greece

  • Birmingham Heartlands Hospital

    Birmingham, B9 5SS, United Kingdom

  • Bkmk Hospital

    KecskemĂŠt, 6000, Hungary

  • Bordeaux University Hospital - Hopital Saint Andre

    Bordeaux, 33075, France

  • CER SAN JUAN - Centro Polivalente de Asistencia e Investigación Clínica

    San Juan, 5400, Argentina

  • CHU de Nantes

    Nantes, 44093, France

  • CHU de Poitier Pole Regional de Cancerologie

    Poitiers, 86000, France

  • CHUO

    Ourense, 32005, Spain

  • Cancer Care Center of Brevard

    Irving, Texas, 75063, United States

  • Cangzhou People's Hospital

    Cangzhou, 610001, China

  • Centre Hospitalier Universitaire de Lille

    Lille, 59000, France

  • Centre Hospitalier Universitaire de Montpellier

    Montpellier, 34295, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centro Clinico Champalimau

    Lisbon, 1400-038, Portugal

  • Centro Hospitalar Universitário de São João

    Porto, 4200-319, Portugal

  • Centro Hospitalar e Universitário do Porto

    Porto, 4099-001, Portugal

  • Centro de Estudios Clínicos SAGA

    Santiago, Santiago Metropolitan, 7500653, Chile

  • Centro de Estudos e Pesquisa de Hematologia e Oncologia - CEPHO

    Santo André, 09060-870, Brazil

  • Centro de Investigacion Clinica de Oaxaca (CICLO)

    Oaxaca City, 68020, Mexico

  • Centro de Investigaciones Clinicas Vina Del Mar

    Viña del Mar, 254-0488, Chile

  • Centro de Investigaciones Medicas y Desarrollo LC S.R.L. (LC Investigacion)

    Buenos Aires, Argentina

  • Centro de Investigación Pergamino S. A.

    Pergamino, 2700, Argentina

  • Centrul de Oncologie Sf Nectarie S.R.L.

    Craiova, 200542, Romania

  • Chang Gung Memorial Hospital Cgmh - Kaohsiung Branch

    Kaohsiung City, 833, Taiwan

  • Chang Gung Memorial Hospital LinKou

    Taoyuan, 333, Taiwan

  • Chris Obrien Lifehouse

    Camperdown, 2050, Australia

  • Chung Shan Medical University Hospital

    Taichung, 40201, Taiwan

  • Chungbuk National University Hospital

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Clinica Viedma SA

    Viedma, 8500, Argentina

  • Clínica de Neoplasias Litoral

    Itajaí, 88301-220, Brazil

  • Cooperman Barnabas Medical Center

    New Brunswick, New Jersey, 08901, United States

  • Cryptex Investigacion Clinica Sa de Cv

    Cuauhtémoc, 06100, Mexico

  • DFCI - South Shore Hospital

    South Weymouth, Massachusetts, 02190, United States

  • Dana Farber Cancer Institute - Foxborough

    Foxborough, Massachusetts, 02035, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshire, 03766, United States

  • Dokkyo Medical University Hospital

    Shimotsuga-gun, Tochigi, 321-0293, Japan

  • Dom Lekarski SA

    Szczecin, West Pomeranian Voivodeship, 70-784, Poland

  • E-Da Hospital

    Kaohsiung City, 824, Taiwan

  • Ege University

    Bornova-İzmir, 35100, Turkey (Türkiye)

  • Evangelische Lungenklinik Berlin

    Berlin, 13125, Germany

  • Faculty of Medicine Chulalongkorn University

    Bangkok, 10330, Thailand

  • Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

    Székesfehérvár, 8000, Hungary

  • Fudan University Shanghai Cancer Center

    Shanghai Shi, 200032, China

  • Fundacion CENIT para la investigación en Neurociencias

    Ciudad Autonoma de Buenos Aire, 1125, Argentina

  • Fundación Arturo Pérez López

    Santiago, 7500921, Chile

  • Goztepe Prof. Dr. Suleyman Yalcin City Hospital

    Istanbul, 34772, Turkey (Türkiye)

  • Grand Hopital de Charleroi - Hopital Saint Joseph

    Charleroi, 6000, Belgium

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, Guangxi, 530021, China

  • Gyeongsang National University Hospital

    Jinju, Gyeongsangnam-do, 52727, South Korea

  • Haikou People's Hospital

    Haikou, 570208, China

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • Henan Cancer Hospital

    Zhengzhou, Henan, 450008, China

  • Hopital FOCH

    Suresnes, 92150, France

  • Hopital prive du Confluent

    Nantes, 44277, France

  • Hospital CUF Porto

    Porto, 4100-180, Portugal

  • Hospital Civil de Guadalajara Fray Antonio Alcalde

    Guadalajara, 44280, Mexico

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Erasto Gaertner

    Curitiba, 81520-060, Brazil

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital Privado de la Comunidad

    Mar del Plata, B7602CBM, Argentina

  • Hospital Regional Universitario Malaga

    Málaga, 29010, Spain

  • Hospital Universitari Vall D'Hebron

    Barcelona, 8035, Spain

  • Hospital Universitari i Politècnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Arnau de Vilanova - Lleida

    Lleida, 25198, Spain

  • Hospital Universitario Dr. Jose Eleuterio Gonzalez

    Monterrey, 64460, Mexico

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Hospital Universitario de Valme

    Seville, 41014, Spain

  • Hubei Cancer Hospital

    Wuhan, 430079, China

  • Hunan Cancer Hospital

    Changsha, 410013, China

  • II Klinika Chorob Pluc I Gruzlicy

    Bialystok, 15-450, Poland

  • IRCCS Istituto Oncologico Giovanni Paolo II

    Bari, 70124, Italy

  • IRCCS Ospedale San Raffaele

    Milan, 20132, Italy

  • Ifo Regina Elena

    Rome, 144, Italy

  • Illinois Cancer Specialists

    Irving, Texas, 75063, United States

  • Inner Mongolia Medical University- the Affiliated Hospital

    Hohhot, 10050, China

  • Institut Bergonie

    Bordeaux, 33076, France

  • Institut Paoli-Calmettes

    Marseille, 13273, France

  • Instituto Nacional de Câncer - INCA

    Rio de Janeiro, 20231-050, Brazil

  • Instituto Portuguas de Oncologia do Porto Francisco Gentil

    Porto, 4200-072, Portugal

  • Instituto de Ensino e Pesquisas Sao Lucas

    São Paulo, 01236-030, Brazil

  • Instituto de Oncología de Rosario

    Rosario, S2000, Argentina

  • Instituto de Pesquisas em Saúde - IPS

    Caxias do Sul, 95020-972, Brazil

  • Instituto do Cancer Brasil - Unidade Taubate

    Taubaté, Brazil

  • Instytut Centrum Zdrowia Matki Polki

    Lodz, Iodzkie, 93-338, Poland

  • Irccs Istituto Europeo Di Oncologia

    Milan, 20141, Italy

  • Ironwood Cancer and Research Center

    Chandler, Arizona, 85224, United States

  • Jeroen Bosch Ziekenhuis J BZ Hieronymus Bosch Hospital

    's-Hertogenbosch, 5223 GZ, Netherlands

  • Jiamusi Tumor and Tuberculosis Hospital

    Jiamusi, 154007, China

  • Jiangsu Province Hospital

    Nanjing, 210029, China

  • Jilin Cancer Hospital

    Changchun, Jilin, 130012, China

  • Johns Hopkins University

    Baltimore, Maryland, 21205, United States

  • Juntendo University Hospital

    Bunkyo-ku, Tokyo, 113-8431, Japan

  • Kanagawa Cancer Center

    Yokohama, Kanagawa, 241-8515, Japan

  • Kanazawa University Hospital

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Kansai Medical University Hospital

    Hirakata-shi, Osaka, 573-1191, Japan

  • Kantonsspital Baden

    Baden, 5404, Switzerland

  • Kantonsspital Baselland

    Liestal, A4410, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, Switzerland

  • Karl-Landsteiner Institute for Lung Research and Pulmonary Oncology c/o Klinik Floridsdorf

    Vienna, 1090, Austria

  • Klinikum Esslingen GmbH

    Esslingen am Neckar, 73730, Germany

  • Klinikum Klagenfurt am Wörthersee Abteilung für Lungenkrankheiten

    Klagenfurt, Austria

  • Klinikum der Universitaet Muenchen

    München, 80336, Germany

  • Koo Foundation Sun Yat-Sen Cancer Center

    Taipei, 112, Taiwan

  • Kurume University Hospital

    Kurume-shi, Fukuoka, 830-0011, Japan

  • Kyungpook National University Chilgok Hospital

    Daegu, 42119, South Korea

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582, Japan

  • Leiden University Medical Center

    Leiden, 2333 ZA, Netherlands

  • Liaoning Cancer Hospital& Institute

    Shenyang, 110801, China

  • Linyi Cancer Hospital

    Linyi, 276000, China

  • LungenClinic Grosshansdorf

    Großhansdorf, 22927, Germany

  • MS Pneumed Janusz Milanowski, Katarzyna Szmygin-Milanowska Sp. Jawna

    Lublin, 20-064, Poland

  • Maryland Oncology Hematology

    Irving, Texas, 75063, United States

  • Matsusaka Municipal Hospital

    Matsusaka-shi, Mie-ken, 515-8544, Japan

  • McGill University Health Centre

    Montreal, H4A 3J2, Canada

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical Park Seyhan Hospital

    Seyhan /Adana, 1140, Turkey (Türkiye)

  • Memorial Ankara Hospital Ankara

    Çankaya, 06520, Turkey (Türkiye)

  • Metropolitan Hospital

    Neo Faliro, Athens, 14564, Greece

  • Metropolitan Hospital

    Neo Faliro, 18547, Greece

  • Metropolitan Hospital

    Piraeus, 18547, Greece

  • Montefiore Medical Center

    The Bronx, New York, 10461, United States

  • NHO Iwakuni Clinical Center

    Iwakuni-shi, Yamaguchi, 740-8510, Japan

  • NHO Kinki-Chuo Chest Medical Center

    Sakai-shi, Osaka, 591-8555, Japan

  • NHO Shikoku Cancer Center

    Matsuyama, Ehime, 791-0280, Japan

  • National Cancer Center

    Goyang-si, 10408, South Korea

  • National Cancer Center Hospital East

    Kashiwa-shi, Chiba, 277-8577, Japan

  • National Cheng Kung University Hospital Nckuh

    Tainan, 704, Taiwan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, Fukuoka, 811-1395, Japan

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • Niigata Cancer Center Hospital

    Niigata, Niigata, 961-8566, Japan

  • Nottingham University Hospitals

    Nottingham, NG5 1PB, United Kingdom

  • Onco Clinic Consult SA

    Craiova, 200094, Romania

  • Oncocenter-Oncologie Clinica SRL

    Timișoara, 300166, Romania

  • Oncologico Potosino

    San Luis Potosí City, 78209, Mexico

  • Oncosite - Centro de Pesquisa Clinica Oncologia

    Ijuí, 98700-000, Brazil

  • Oncovida

    Santiago, 7500000, Chile

  • Onze-Lieve-Vrouwziekenhuis Olvz - Campus Aalst

    Aalst, 9300, Belgium

  • Orlandi Oncología

    Santiago, 7501010, Chile

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Osaka Toneyama Medical Center

    Osaka, 560-8552, Japan

  • Ospedale San Luca

    Lucca, 55100, Italy

  • PIH Health Whittier Hospital

    Whittier, California, 90602, United States

  • Peking University Cancer Hospital

    Beijing, 100142, China

  • Peking University Peoples Hospital

    Beijing, 100044, China

  • Peninsula and South Eastern Haematology and Oncology Group

    Mount Waverley, Victoria, 3149, Australia

  • Policlinico Tor Vergata

    Rome, 133, Italy

  • Prince of Songkla University PSU - Faculty of Medicine

    Hat Yai, Changwat Songkhla, 90110, Thailand

  • Prince of Wales Hospital / The Chinese University of Hong Kong 99999

    Hong Kong, 99999, Hong Kong

  • Providence Regional Cancer System

    Lacey, Washington, 98503, United States

  • Pulmonology Hospital Torokbalint

    Törökbálint, 2045, Hungary

  • Queen Elizabeth Hospital

    Hong Kong, Hong Kong

  • Queen Mary Hospital

    Pok Fu Lam, 999077, Hong Kong

  • Regional Cancer Care Associates LLC

    Freehold, New Jersey, 07728, United States

  • Ridley-Tree Cancer Center

    Santa Barbara, California, 93105, United States

  • Rijnstate Ziekenhuis

    Arnhem, Gelderland, 6815 AD, Netherlands

  • SC Oncomed SRL

    Timișoara, 300239, Romania

  • Sainte-Catherine Institut du Cancer Avignon-Provence (ICAP)

    Avignon, 84000, France

  • Saiseikai Kumamoto Hospital

    Kumamoto, Kumamoto, 861- 4193, Japan

  • Samsung Medical Center

    Seoul, 6351, South Korea

  • Sanatorio Británico de Rosario

    Rosario, S2002, Argentina

  • Sanatorio Parque

    Rosario, S2001, Argentina

  • Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, 90050-170, Brazil

  • Sc Sigmedical Services Srl

    Suceava, 720214, Romania

  • Semmelweis University Department of Pulmonology

    Budapest, 1083, Hungary

  • Sendai Kousei Hospital

    Sendai, Miyagi, 980-0873, Japan

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Shanghai Pulmonary Hospital

    Shanghai, 200433, China

  • Sichuan Cancer Hospital

    Chengdu, Sichuan, 610049, China

  • Siriraj Hospital

    Bangkok, 10700, Thailand

  • Sotiria General Hosptial of Chest Diseases

    Athens, 11527, Greece

  • Southern Cancer Center

    Irving, Texas, 75063, United States

  • Srinagarind Hospital

    Muaeng, Changwat Khon Kaen, 40002, Thailand

  • St. Luke's Hospital

    Thessaloniki, 55236, Greece

  • Szpitale Pomorskie Sp. z o.o.

    Gdynia, Pomeranian Voivodeship, 81-519, Poland

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Teine Keijinkai Hospital

    Sapporo, 006-8555, Japan

  • Texas Oncology - Northeast Texas

    Irving, Texas, 75063, United States

  • Texas Oncology Gulf Coast

    Irving, Texas, 75063, United States

  • Texas Oncology McAllen

    Irving, Texas, 75063, United States

  • The Cancer Institute Hospital of JFCR

    Kōtoku, Toyko, 135-8550, Japan

  • The Catholic Univ. of Korea, Seoul St. Mary'S Hospital

    Seoul, 6591, South Korea

  • The First Affiliate Hospitalof Xi'An Jiaotong University

    Xi'an, 710061, China

  • The First Affiliated Hospital Xiamen University

    Xiamen, 361001, China

  • The First Affiliated Hospital of College of Medicine Zhejiang University

    Hanghzou, 310003, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, 330006, China

  • The First Hospital of China Medical University

    Shenyang, 110001, China

  • The Oncology Institute of Hope and Innovation

    Whittier, California, 90603, United States

  • The Queen Elizabeth Hospital

    Woodville South, 5011, Australia

  • The Second People's Hospital of Neijiang

    Neijiang, 641000, China

  • The Valley Hospital

    Paramus, New Jersey, 07652, United States

  • Tianjin Medical University General Hospital

    Tianjin, 300052, China

  • Toho University Omori Medical Center

    Ōta-ku, Toyko, 143-8541, Japan

  • Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

    Bunkyō-Ku, Tokyo, 113-8677, Japan

  • UCLA HemOnc - Clinical Research Unit

    Los Angeles, California, 90095, United States

  • UOC Oncologia

    Chieti, 66100, Italy

  • UPCO - Unidade de Pesquisas Clínicas em Oncologia - Clinica Lacks

    Pelotas, 96020-080, Brazil

  • Uch-Mhs D/B/A Memorial Health System

    Colorado Springs, Colorado, 80909, United States

  • Union Hospital Affiliated With Tongji Medical College Huazhong University of Science and Technology

    Wuhan, 430022, China

  • University Hospital Basel

    Basel, 4031, Switzerland

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566, Japan

  • University Hospital of Ioannina Uhi

    Ioannina, 45500, Greece

  • University of Texas Health Science Center San Antonio

    San Antonio, Texas, 78229, United States

  • Utah Cancer Specialists

    Salt Lake City, Utah, 84106, United States

  • VA Puget Sound Health Care System - VAPSHCS

    Seattle, Washington, 98108, United States

  • Veszprem Megyei Tudogyogyintezet Farkasgyepu

    Farkasgyepű, 8582, Hungary

  • Xiangyang Central Hospital- 5 Lumen Avenue

    Xiangyang, 441000, China

  • Xinjiang Tumor Hospital

    Ürümqi, 830000, China

  • Yamaguchi-Ube Medical Center

    Ube-shi, Yamaguchi, 755-0241, Japan

  • Yamanashi Prefectural Central Hospital

    Kofu, Japan

  • Yunnan Cancer Hospital

    Kunming, 650118, China