Hormone therapy duo shows promise against rare salivary cancer

NCT ID NCT05669664

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 23 times

Summary

This study tests two drugs that lower or block male hormones to slow or shrink a rare type of salivary gland cancer that has spread or come back. About 21 people whose cancer has a specific protein (androgen receptor) will receive daily darolutamide pills plus leuprolide injections. The main goal is to see how many patients' tumors shrink or disappear.

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Contacts and locations

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Locations

Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612, United States
UChicago Medicine Northwest Indiana

Crown Point, Indiana, 46307, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center

Madison, Wisconsin, 53718, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

Conditions

Explore the condition pages connected to this study.

LOCALLY ADVANCED SALIVARY GLAND CARCINOMA METASTATIC SALIVARY GLAND CARCINOMA RECURRENT SALIVARY GLAND CARCINOMA UNRESECTABLE SALIVARY GLAND CARCINOMA