New immune therapy shows promise for Tough-to-Treat cancers

NCT ID NCT05882058

Recruiting now Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 05, 2026 · Updated 24 times

Summary

This study tests a new drug, BI 764532 (obrixtamig), in adults with advanced small cell lung cancer or other neuroendocrine cancers that have stopped responding to treatment. The drug is designed to help the immune system attack cancer cells. The main goals are to find a safe dose and see if the drug can shrink tumors. About 204 participants will receive the drug by IV infusion, with regular checkups to monitor safety and effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

960 Hospital of the Chinese People's Liberation Army
RECRUITING

Jinan, 250031, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
Aichi Cancer Center Hospital
RECRUITING

Aichi, Nagoya, 464-8681, Japan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Asan Medical Center
COMPLETED

Seoul, 05505, South Korea
Asklepios Fachkliniken München-Gauting
COMPLETED

Gauting, 82131, Germany
Chang Gung Memorial Hospital, Linkou
COMPLETED

Taoyuan County, 333, Taiwan
Dana-Farber Cancer Institute
COMPLETED

Boston, Massachusetts, 02215, United States
Evangelische Lungenklinik Berlin
COMPLETED

Berlin, 13125, Germany
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
H. Lee Moffitt Cancer Center and Research Institute
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
HOP Civil
COMPLETED

Strasbourg, 67091, France
HOP Intercommunal
COMPLETED

Créteil, 94000, France
Hospital CUF Descobertas-Lisboa-69316
RECRUITING

Lisbon, 1350-352, Portugal

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hospital CUF Porto
COMPLETED

Porto, 4100-180, Portugal
Hospital Clinico Universitario de Valencia
COMPLETED

Valencia, 46010, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain

Contact Phone: •••-•••-•••• Email: •••••@•••••
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain

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Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain

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Hospital del Mar
COMPLETED

Barcelona, 08003, Spain
Hôpital Cochin
COMPLETED

Paris, 75014, France
Indiana University
COMPLETED

Indianapolis, Indiana, 46202, United States
Infirmary Cancer Care
RECRUITING

Mobile, Alabama, 36607, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Japanese Foundation for Cancer Research
RECRUITING

Tokyo, Koto-ku, 135-8550, Japan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Kindai University Hospital
RECRUITING

Osaka, Sakai, 590-0197, Japan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Leicester Royal Infirmary
RECRUITING

Leicester, LE1 5WW, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
LungenClinic Grosshansdorf GmbH
ACTIVE_NOT_RECRUITING

Großhansdorf, 22927, Germany
MHAT Heart and brain
COMPLETED

Pleven, 5800, Bulgaria
Mayo Clinic Cancer Center
RECRUITING

Jacksonville, Florida, 32224, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mayo Clinic, Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Mayo Clinic-Arizona
RECRUITING

Phoenix, Arizona, 85054, United States

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Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Multiprofile Hospital For Active Treatment-Uni Hospital Ltd.
COMPLETED

Panagyurishte, 4500, Bulgaria
NCKUH
COMPLETED

Tainan, 704, Taiwan
National Cancer Center Hospital
RECRUITING

Tokyo, Chuo-ku, 104-0045, Japan

Contact Phone: •••-•••-•••• Email: •••••@•••••
National Cancer Center Hospital East
RECRUITING

Chiba, Kashiwa, 277-8577, Japan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Osaka International Cancer Institute
RECRUITING

Osaka, Osaka, 541-8567, Japan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Qilu Hospital, Shangdong University
RECRUITING

Jinan, 250012, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
Samsung Medical Center
ACTIVE_NOT_RECRUITING

Seoul, 06351, South Korea
Sendai Kousei Hospital
COMPLETED

Miyagi, Sendai, 981-0914, Japan
Severance Hospital
RECRUITING

Seoul, 03722, South Korea

Contact Phone: •••-•••-•••• Email: •••••@•••••
Shanghai Chest Hospital
RECRUITING

Shanghai, 200030, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
RECRUITING

Hangzhou, 310016, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
Taipei Veterans General Hospital
COMPLETED

Taipei, 11217, Taiwan
The Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom

Contact Phone: •••-•••-•••• Email: •••••@•••••
The Second Affiliated Hospital to Nanchang University
RECRUITING

Nanchang, 330006, China

Contact Phone: •••-•••-•••• Email: •••••@•••••
UZ Leuven
RECRUITING

Leuven, 3000, Belgium

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitair Ziekenhuis Gent
RECRUITING

Ghent, 9000, Belgium

Contact Phone: •••-•••-•••• Email: •••••@•••••
University College Hospital
RECRUITING

London, WC1E 6AG, United Kingdom

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University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Kansas Cancer Center
NOT_YET_RECRUITING

Westwood, Kansas, 66205, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21201, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Miami
RECRUITING

Miami, Florida, 33136, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitätsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 01307, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitätsklinikum Erlangen
RECRUITING

Erlangen, 91054, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
RECRUITING

Mainz, 55131, Germany

Contact Phone: •••-•••-•••• Email: •••••@•••••
Valkyrie Clinical Trials
RECRUITING

Los Angeles, California, 90067, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Virginia Commonwealth University Health- Adult Outpatient Pavilion
RECRUITING

Richmond, Virginia, 23219, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
West China Hospital, Sichuan University
RECRUITING

Chengdu, 610041, China

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

EXTRA-PULMONARY NEUROENDOCRINE CARCINOMA EXTRA-PULMONARY NEUROENDOCRINE CARCINOMA NEUROENDOCRINE NEOPLASMS NEUROENDOCRINE NEOPLASMS SMALL CELL LUNG CARCINOMA