New drug combo tested for rare, Heart-Damaging protein disease

NCT ID NCT05250973

Ongoing Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing a treatment called D-VCd (daratumumab plus other drugs) for people newly diagnosed with AL amyloidosis, a rare disease where abnormal proteins build up and damage organs, especially the heart. The main goals are to check the treatment's safety for the heart and to see how the drug behaves in the body, with a special focus on including Black or African American participants. It is for people who have not had prior treatment for this condition.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alexandra General Hospital of Athens

Athens, 11528, Greece
Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Boston University Medical Center

Boston, Massachusetts, 02118, United States
CHU De Poitiers

Poitiers, 86000, France
CHU Rangueil

Toulouse, 31400, France
CHU de Limoges

Limoges, 87042, France
Centre hospitalier Lyon-Sud

Pierre-Bénite, 69495, France
Charite Campus Benjamin Franklin

Berlin, 12203, Germany
City of Hope

Duarte, California, 91010, United States
Clinica Univ. de Navarra

Madrid, 28027, Spain
Clinica Univ. de Navarra

Pamplona, 31008, Spain
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA''

Roma, 00161, Italy
First affiliated Hospital of Zhejiang University

Hangzhou, 310020, China
Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy
Hosp Clinic de Barcelona

Barcelona, 08036, Spain
Hosp Clinico Univ de Salamanca

Salamanca, 37007, Spain
Hosp Univ Vall D Hebron

Barcelona, 08035, Spain
Hosp. Univ. Germans Trias I Pujol

Badalona, 08916, Spain
Hospital Maastricht University Medical Center

Maastricht, 6229 HX, Netherlands
Leicester Royal Infirmary - Haematology

Leicester, LE1 5WW, United Kingdom
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Memorial Sloan Kettering

New York, New York, 10021, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Ohio Health Research Institute

Columbus, Ohio, 43214, United States
Peking University First Hospital

Beijing, 100034, China
Peking University People's Hospital

Beijing, 100044, China
Ruijin Hospital Shanghai Jiao Tong University

Shanghai, 200025, China
Smilow Cancer Hospital/Yale Cancer Center

New Haven, Connecticut, 06510, United States
Tom Baker Cancer Center

Calgary, Alberta, T2N 4N2, Canada
Tufts Medical Center

Boston, Massachusetts, 02111, United States
UMC Utrecht

Utrecht, 3584 CX, Netherlands
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
Universitaetsklinikum Heidelberg Medizinische Klinik V

Heidelberg, 69120, Germany
Universitatsklinikum Essen

Essen, 45122, Germany
University College Hospital

London, NW1 2PG, United Kingdom
University Health Network UHN Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
University Hospital of Cleveland

Cleveland, Ohio, 44106, United States
University Medical Center Groningen

Groningen, 9713 GZ, Netherlands
University of Washington

Seattle, Washington, 90805, United States
Università Degli Studi Di Napoli Federico Ii

Napoli, 80131, Italy
VCU Medical Center

Richmond, Virginia, 23219, United States
Wake Forest University - Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
West China Hospital Si Chuan University

Chengdu, 610041, China
West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States
Winship Cancer Institute Emory University

Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.

AMYLOIDOSIS