Eye disease drug trial halted: danicopan fails to slow vision loss?

NCT ID NCT05019521

Terminated Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 03, 2026 · Updated 21 times

Summary

This study tested a drug called danicopan in 365 people with geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. The goal was to see if different doses could slow the growth of these spots over two years. The trial was stopped early, so results are not yet available.

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Phoenix, Arizona, 85020, United States
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Beverly Hills, California, 90211, United States
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Encino, California, 91436, United States
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Fresno, California, 93720, United States
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Fullerton, California, 92835, United States
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La Jolla, California, 92093, United States
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Pasadena, California, 91105, United States
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Sacramento, California, 95841, United States
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San Mateo, California, 94401, United States
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Walnut Creek, California, 94598, United States
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Colorado Springs, Colorado, 80909, United States
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Longmont, Colorado, 80503, United States
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Waterford, Connecticut, 06385, United States
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Clearwater, Florida, 33761, United States
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Coral Springs, Florida, 33067, United States
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Deerfield Beach, Florida, 33064, United States
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Naples, Florida, 34103, United States
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Palm Beach Gardens, Florida, 33418, United States
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St. Petersburg, Florida, 33711, United States
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Augusta, Georgia, 30909, United States
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New Albany, Indiana, 47150, United States
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West Des Moines, Iowa, 50266, United States
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Hagerstown, Maryland, 21740, United States
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Rosedale, Maryland, 21237, United States
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Towson, Maryland, 21204, United States
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Springfield, Massachusetts, 01107, United States
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Southaven, Mississippi, 38671, United States
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Reno, Nevada, 89502, United States
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Teaneck, New Jersey, 07666, United States
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Great Neck, New York, 11021, United States
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Durham, North Carolina, 27705, United States
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Cincinnati, Ohio, 45219, United States
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Portland, Oregon, 97225, United States
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Springfield, Oregon, 97477, United States
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Kingston, Pennsylvania, 18704, United States
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Monroeville, Pennsylvania, 15146, United States
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Philadelphia, Pennsylvania, 19104-2640, United States
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Philadelphia, Pennsylvania, 19107, United States
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Greenville, South Carolina, 29605, United States
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Austin, Texas, 78750, United States
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Bellaire, Texas, 77401, United States
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Conroe, Texas, 77384, United States
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Southlake, Texas, 76092, United States
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Fairfax, Virginia, 22031, United States
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Lynchburg, Virginia, 24502, United States
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Adelaide, 5000, Australia
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Albury, 2640, Australia
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East Melbourne, 3002, Australia
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Hurstville, 2220, Australia
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Parramatta, 2150, Australia
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Strathfield, 2135, Australia
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Sydney, 2000, Australia
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Pardubice, 530 02, Czechia
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Prague, 150 00, Czechia
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Créteil, 94010, France
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Écully, 69130, France
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Lyon, 69004, France
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Marseille, 13008, France
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Nantes, 44000, France
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Nice, 06000, France
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Paris, 75010, France
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Paris, 75019, France
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Paris, 75571, France
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Poitiers, 86021, France
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Strasbourg, 67091, France
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Berlin, 12203, Germany
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Bonn, 53127, Germany
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Düsseldorf, 40225, Germany
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Freiburg im Breisgau, 79106, Germany
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Göttingen, 37075, Germany
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Hanover, 30625, Germany
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Heidelberg, 69120, Germany
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Mainz A. Rhein, 55131, Germany
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Marburg, 35043, Germany
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München, 81675, Germany
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Münster, 48145, Germany
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Münster, 48149, Germany
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Neubrandenburg, 17036, Germany
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Regensburg, 93053, Germany
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Tübingen, 72076, Germany
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Ulm, 89081, Germany
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Würzburg, 97080, Germany
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Budapest, 1133, Hungary
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Pécs, 7621, Hungary
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Florence, 50134, Italy
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Genova, 16132, Italy
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Milan, 20122, Italy
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Milan, 20132, Italy
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Milan, 20157, Italy
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Naples, 80131, Italy
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Roma, 00133, Italy
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Roma, 00168, Italy
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Fukushima, 960-1295, Japan
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Kita-gun, 761-0793, Japan
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Osaka, 5458586, Japan
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Riga, LV-1009, Latvia
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Riga, LV1002, Latvia
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Bratislava, 811 08, Slovakia
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Žilina, 012 07, Slovakia
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Busan, 49241, South Korea
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Daegu, 42415, South Korea
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Incheon, 22332, South Korea
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Jinju, 52727, South Korea
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Seoul, 03082, South Korea
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Seoul, 06351, South Korea
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Barcelona, 08022, Spain
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Barcelona, 08035, Spain
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Barcelona, 8025, Spain
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Bilbao, 48006, Spain
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Córdoba, 14012, Spain
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Majadahonda, 28222, Spain
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Pamplona, 31005, Spain
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Seville, 41071, Spain
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Valencia, 46014, Spain
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Valladolid, 46012, Spain
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Zaragoza, 50009, Spain
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Bristol, BS1 2LX, United Kingdom
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Liverpool, L69 3BX, United Kingdom
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London, EC1V 2PD, United Kingdom
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London, GU16 7UJ, United Kingdom
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London, NW1 5QH, United Kingdom
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London, SE5 9RS, United Kingdom
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Newcastle upon Tyne, NE7 7DN, United Kingdom
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Southampton, S016 6YD, United Kingdom

Conditions

Explore the condition pages connected to this study.

GEOGRAPHIC ATROPHY