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New drug combo targets rare genetic tumor marker in observational trial

NCT ID NCT06262919

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study watches how safe and effective two drugs, dabrafenib and trametinib, are for people with advanced or recurrent solid tumors that have a specific genetic change called BRAF V600E. About 110 adults and children will be followed to track side effects and tumor shrinkage. The goal is to see if these drugs can control the disease in real-world settings.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAF V600E MUTATION-POSITIVE UNRESECTABLE ADVANCED OR RECURRENT SOLID TUMOR

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • Novartis Investigative Site

    COMPLETED

    Nagakute, Aichi-ken, 480-1195, Japan

  • Novartis Investigative Site

    RECRUITING

    Nagoya, Aichi-ken, 453-8511, Japan

  • Novartis Investigative Site

    COMPLETED

    Nagoya, Aichi-ken, 453-8511, Japan

  • Novartis Investigative Site

    COMPLETED

    Nagoya, Aichi-ken, 4648681, Japan

  • Novartis Investigative Site

    COMPLETED

    Toyohashi, Aichi-ken, 441-8570, Japan

  • Novartis Investigative Site

    COMPLETED

    Toyota, Aichi-ken, 470-0343, Japan

  • Novartis Investigative Site

    COMPLETED

    Daisen, Akita, 0140027, Japan

  • Novartis Investigative Site

    WITHDRAWN

    Chiba, Chiba, 2608677, Japan

  • Novartis Investigative Site

    COMPLETED

    Funabashi, Chiba, 273-8588, Japan

  • Novartis Investigative Site

    RECRUITING

    Kashiwa, Chiba, 277-8577, Japan

  • Novartis Investigative Site

    RECRUITING

    Yoshida-gun, Fukui, 910-1193, Japan

  • Novartis Investigative Site

    RECRUITING

    Fukuoka, Fukuoka, 811-1395, Japan

  • Novartis Investigative Site

    RECRUITING

    Kurume, Fukuoka, 830-0011, Japan

  • Novartis Investigative Site

    RECRUITING

    Fukuyama, Hiroshima, 721-8511, Japan

  • Novartis Investigative Site

    RECRUITING

    Sapporo, Hokkaido, 0608543, Japan

  • Novartis Investigative Site

    RECRUITING

    Sapporo, Hokkaido, 0650033, Japan

  • Novartis Investigative Site

    COMPLETED

    Amagasaki, Hyōgo, 660-8511, Japan

  • Novartis Investigative Site

    COMPLETED

    Kobe, Hyōgo, 650-0011, Japan

  • Novartis Investigative Site

    RECRUITING

    Kobe, Hyōgo, 6500047, Japan

  • Novartis Investigative Site

    RECRUITING

    Mito, Ibaraki, 311-4145, Japan

  • Novartis Investigative Site

    COMPLETED

    Morioka, Iwate, 0200066, Japan

  • Novartis Investigative Site

    RECRUITING

    Sagamihara, Kanagawa, 252-0375, Japan

  • Novartis Investigative Site

    RECRUITING

    Yokohama, Kanagawa, 236-0004, Japan

  • Novartis Investigative Site

    RECRUITING

    Yokohama, Kanagawa, 245-8575, Japan

  • Novartis Investigative Site

    RECRUITING

    Kyoto, Kyoto, 602-8566, Japan

  • Novartis Investigative Site

    COMPLETED

    Natori-shi, Miyagi, 981-1293, Japan

  • Novartis Investigative Site

    RECRUITING

    Sendai, Miyagi, 9808574, Japan

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Iida, Nagano, 395-8502, Japan

  • Novartis Investigative Site

    RECRUITING

    Matsumoto, Nagano, 3908621, Japan

  • Novartis Investigative Site

    COMPLETED

    Matsumoto, Nagano, 3908621, Japan

  • Novartis Investigative Site

    RECRUITING

    Yufu, Oita Prefecture, 8795593, Japan

  • Novartis Investigative Site

    RECRUITING

    Okayama, Okayama-ken, 7011192, Japan

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Habikino, Osaka, 583-0872, Japan

  • Novartis Investigative Site

    COMPLETED

    Izumisano, Osaka, 5988577, Japan

  • Novartis Investigative Site

    RECRUITING

    Osaka, Osaka, 5340021, Japan

  • Novartis Investigative Site

    COMPLETED

    Osaka, Osaka, 5340021, Japan

  • Novartis Investigative Site

    COMPLETED

    Osaka, Osaka, 550-0015, Japan

  • Novartis Investigative Site

    RECRUITING

    Takatsuki, Osaka, 5698686, Japan

  • Novartis Investigative Site

    RECRUITING

    Kawagoe, Saitama, 3508550, Japan

  • Novartis Investigative Site

    RECRUITING

    Saitama, Saitama, 330-8777, Japan

  • Novartis Investigative Site

    RECRUITING

    Ohtsu, Shiga, 5202192, Japan

  • Novartis Investigative Site

    RECRUITING

    Sunto Gun, Shizuoka, 4118777, Japan

  • Novartis Investigative Site

    COMPLETED

    Shimotsuke, Tochigi, 329-0498, Japan

  • Novartis Investigative Site

    RECRUITING

    Bunkyo Ku, Tokyo, 113-8655, Japan

  • Novartis Investigative Site

    COMPLETED

    Bunkyo Ku, Tokyo, 113-8655, Japan

  • Novartis Investigative Site

    COMPLETED

    Bunkyo-ku, Tokyo, 113-8603, Japan

  • Novartis Investigative Site

    RECRUITING

    Bunkyo-ku, Tokyo, 1138519, Japan

  • Novartis Investigative Site

    COMPLETED

    Bunkyo-ku, Tokyo, 1138519, Japan

  • Novartis Investigative Site

    RECRUITING

    Chuo Ku, Tokyo, 104-8560, Japan

  • Novartis Investigative Site

    COMPLETED

    Chuo Ku, Tokyo, 1040045, Japan

  • Novartis Investigative Site

    RECRUITING

    Chuo Ku, Tokyo, 1040045, Japan

  • Novartis Investigative Site

    RECRUITING

    Minato-ku, Tokyo, 105-8471, Japan

  • Novartis Investigative Site

    COMPLETED

    Minato-ku, Tokyo, 108-8639, Japan

  • Novartis Investigative Site

    RECRUITING

    Setagaya-ku, Tokyo, 1578535, Japan

  • Novartis Investigative Site

    COMPLETED

    Shibuya City, Tokyo, 150-8308, Japan

  • Novartis Investigative Site

    COMPLETED

    Shinjuku Ku, Tokyo, 160-0023, Japan

  • Novartis Investigative Site

    COMPLETED

    Shinjuku Ku, Tokyo, 1628666, Japan

  • Novartis Investigative Site

    RECRUITING

    Shinjuku-ku, Tokyo, 1608582, Japan

  • Novartis Investigative Site

    COMPLETED

    Wakayama, Wakayama, 641-8510, Japan

  • Novartis Investigative Site

    RECRUITING

    Wakayama, Wakayama, 641-8510, Japan

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Yamagata, Yamagata, 990-9585, Japan

  • Novartis Investigative Site

    ACTIVE_NOT_RECRUITING

    Akita, 0108543, Japan

  • Novartis Investigative Site

    RECRUITING

    Fukuoka, 8128582, Japan

  • Novartis Investigative Site

    RECRUITING

    Hiroshima, 7348551, Japan

  • Novartis Investigative Site

    RECRUITING

    Kagoshima, 8908520, Japan

  • Novartis Investigative Site

    RECRUITING

    Kochi, 7818555, Japan

  • Novartis Investigative Site

    RECRUITING

    Kyoto, 6068507, Japan

  • Novartis Investigative Site

    RECRUITING

    Okayama, 7008558, Japan

  • Novartis Investigative Site

    COMPLETED

    Osaka, 5458586, Japan

  • Novartis Investigative Site

    RECRUITING

    Shizuoka, 4208660, Japan