New eye drop trial targets chronic dry eye in transplant survivors

NCT ID NCT06852768

Ongoing Disease control Sponsor: Regenerative Ocular Immunobiologics LLC Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This early-phase trial tests whether d-MAPPS eye drops can safely and effectively treat chronic ocular graft-versus-host disease (oGVHD), a painful dry eye condition that can occur after a stem cell transplant. One adult participant will use the drops or a placebo four times daily for 90 days. Researchers will track symptom changes using dry eye questionnaires and eye scores.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: d-MAPPS ophthalmic solution (eye drops made from a biological substance)
What this could lead to: If it works, this could point toward a new treatment for chronic dry eye caused by graft-versus-host disease, potentially easing symptoms like grittiness and irritation.
What could go wrong: This is a very early, small trial with only 1 participant, so results may not apply to others. The treatment is compared to placebo, and it may not prove effective or safe in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic graft versus host disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OGHVD

Contacts and locations

Locations

Beach Eye Medical Group

Huntington Beach, California, 92648, United States
Beverly Hills Institute of Ophthalmology

Beverly Hills, California, 90210, United States
BostonSight

Boston, Massachusetts, 02494, United States
Eyewell, LLC.

Boston, Massachusetts, 02215, United States
Glenn Eye Center

Lexington, Kentucky, 40511, United States
Regenerative Ocular Immunobiologics, LLC.

Palm Harbor, Florida, 34684, United States