Your genes may decide if tramadol eases Post-C-Section pain
NCT ID NCT06814652
First seen Aug 28, 2026 · Last updated Aug 28, 2026
Summary
This study looks at whether genetic differences in the CYP2D6 enzyme affect how well tramadol relieves pain after a cesarean section. Researchers will test blood samples from 40 women in Erbil, Iraq, for gene variants, then give each woman a standard dose of tramadol and track their pain scores, blood pressure, heart rate, and oxygen levels for 24 hours. The goal is to see if certain gene variants are linked to weaker pain relief or stronger side effects, which could help personalize pain treatment in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Tramadol (Trodon® Hemofarm)
- What this could lead to
- If this works, it could help doctors predict which women will get good pain relief from tramadol after a C-section, and which might need a different painkiller.
- What could go wrong
- This is a small, early study with only 40 participants, so the results may not apply to everyone. Also, gene tests don't always predict real-world pain relief perfectly.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
-
40 people
The number who actually took part.
- Started
-
Sep 2024
- Finished
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Apr 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Pregnant patients who were indicated for elective cesarean section surgery at public hospital (Maternity Teaching hospital) located in Erbil city, Iraq were enrolled.
- Ages
-
18 to 50 years
- Sex
-
Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female patients aged between 18-50 years old * Patients who are indicated to undergo elective cesarean section surgery * Patients that are indicated to receive tramadol drug for postpartum pain management Exclusion Criteria: * Patients with any history of severe renal, liver, respiratory diseases and/or seizures * Patients with history of psychiatric disorders or unable to provide consent * Patients with complicated surgeries or neonatal distress or unable to perform the clinical assessment of pain * Patients with history of consumption of chronic alcohol or opioid or drug abuse * Patients with history of known allergy to tramadol
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hawler Medical University/ College of Medicine
Erbil, 40/0112, Iraq
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