New drug shows promise for rare overgrowth conditions
NCT ID NCT06975618
First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This study tests a new drug called CYH33 in people with rare conditions that cause abnormal tissue growth and blood vessel malformations (PROS and PRVM). The trial has two phases: phase I finds the safest dose, and phase II checks if the drug shrinks growths. About 141 adults and adolescents will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CYH33 (a PI3Kα inhibitor)
What this could lead to
If successful, this could lead to a new treatment option that shrinks abnormal growths and improves symptoms for people with PROS and PRVM.
What could go wrong
This is an early-phase trial (phase I/II) with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to show benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Capital Center for Children's Health, Capital Medical University
RECRUITINGBeijing, Beijing Municipality, 100000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fujian Medical University Union Hospital
RECRUITINGFuzhou, Fujian, 350001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Gifu University Hospital
RECRUITINGGifu, 501-1194, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Guangzhou Women and Children's Medical Center
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Henan Provincial People's Hospital
RECRUITINGZhengzhou, Henan, 450003, China
Contact
Contact
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Kyorin University Hospital
RECRUITINGMitaka, Tokyo, 181-8611, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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National Hospital Organization Kobe Medical Center
RECRUITINGKobe, Hyōgo, 654-0155, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Plastic Surgery Hospital, Chinese Academy of Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100144, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shanghai Ninth People Hospital, Shanghai Jiaotong University School of Medicine
RECRUITINGShanghai, Shanghai Municipality, 200011, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shinshu University Hospital
RECRUITINGMatsumoto, Nagano, 390-8621, Japan
Contact
Contact
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The Second Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, 410011, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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Tohoku University Hospital
RECRUITINGSendai, Miyagi, 980-8574, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tonan Hospital
RECRUITINGSapporo, Hokkaido, 060-0004, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
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West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, 610041, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yokohama City University Hospital
RECRUITINGYokohama, Kanagawa, 236-0004, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact