Spice mix may soothe Runner's joint pain during 175 km race
NCT ID NCT07699575
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This trial investigates whether a 30-day course of a supplement containing curcumin, ginger, and piperine can reduce knee pain and inflammation in ultra-trail runners during a 175 km race. One hundred runners are randomly assigned to receive either the supplement or a placebo, and their pain levels are measured before and after the race. The goal is to see if this natural combination can help manage exercise-induced joint discomfort.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- curcumin, ginger, and piperine supplement
- What this could lead to
- If it works, this could point toward a natural supplement for reducing exercise-related joint pain and inflammation in endurance athletes.
- What could go wrong
- This is a single trial in a specific group of ultra-trail runners, so results may not apply to the general population. Supplements can also cause digestive upset or interact with medications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years at inclusion * Registered for "La Diagonale des Fous" (Grand Raid de La Réunion, 175 km, 2026 edition) * Free, informed, signed consent obtained prior to any study-related procedure * Availability to participate in the full protocol, including preliminary consultations and biological sampling at all time points (T0 to T3) * Affiliated with or beneficiary of a social security scheme * Ability to understand and follow study instructions (sufficient French language level, or assistance available) Exclusion Criteria: * Regular NSAID use in the 30 days prior to inclusion, defined as intake at least 3 days/week for at least 2 consecutive weeks, or ongoing treatment at the time of inclusion * Regular use of curcumin-containing supplements or "9-5-1"-type preparations in the 30 days prior to inclusion, defined as intake at least 3 days/week for at least 2 consecutive weeks * Taking anticoagulant treatment * History of hepatic, biliary, or pancreatic disease, including: gallstones, cholestasis, acute or chronic hepatitis, cirrhosis * Known allergy or documented hypersensitivity to any capsule component: turmeric, curcumin, ginger, black pepper, maltodextrin, or hydroxypropylmethylcellulose (HPMC) * Chronic inflammatory joint disease (e.g., rheumatoid arthritis, spondyloarthritis) under active specific treatment * Pregnancy or breastfeeding * Participation in another biomedical study involving a therapeutic intervention within the 30 days prior to inclusion * Severe cognitive or psychiatric impairment preventing understanding of the protocol or completion of questionnaires * Patient under guardianship/curatorship or subject to a legal protection order
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.