New pill aims to tame CAR t-cell side effects in lymphoma patients
NCT ID NCT05905328
First seen Nov 01, 2025 · Last updated May 06, 2026 · Updated 29 times
Summary
This study tests a new drug called CTO1681 to prevent or reduce cytokine release syndrome (CRS), a serious immune overreaction, in adults with diffuse large B-cell lymphoma who are receiving CAR T-cell therapy. About 54 participants will take CTO1681 three times daily for 15 days starting just before their CAR T-cell infusion. The goal is to see if the drug is safe and can lower the risk of CRS and related complications.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke Cancer Institute
RECRUITINGDurham, North Carolina, 27705, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Georgia Cancer Center at Augusta University
RECRUITINGAugusta, Georgia, 30912, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, Irvine - Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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