New drug aims to cut short sickle cell pain attacks

NCT ID NCT06699849

Recruiting now Symptom relief Sponsor: CSL Behring Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study tests an investigational drug called CSL889 in 70 adults and adolescents with sickle cell disease who are having a painful vaso-occlusive crisis. The goal is to see if the drug can safely shorten the crisis and reduce the need for strong pain medicines. Participants will receive either CSL889 or a placebo by IV, and researchers will monitor how quickly the pain resolves and any side effects.

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Conditions

The condition(s) this trial relates to.

acute chest syndrome acute kidney injury sickle cell disease Vaso-Occlusive Crises

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL DISEASE VASO-OCCLUSIVE CRISIS

Contacts and locations

Locations

Arthur M. Blank Hospital-Children's Healthcare of Atlanta
RECRUITING

Atlanta, Georgia, 30329, United States
Baskent University School of Medicine
RECRUITING

Adana, 01120, Turkey (Türkiye)
Detroit Medical Center
RECRUITING

Detroit, Michigan, 48201, United States
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Golisano Children's Hospital
RECRUITING

Fort Myers, Florida, 33908, United States
Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
Hacettepe Universitesi
NOT_YET_RECRUITING

Ankara, 06230, Turkey (Türkiye)
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
Istanbul Universitesi
NOT_YET_RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Jacobi Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Medical Park Mersin Hospital
RECRUITING

Mezitli-Mersin, 33200, Turkey (Türkiye)
Mount Sinai Medical Center
RECRUITING

New York, New York, 10029, United States
St. Louis Children's Hospital
RECRUITING

St Louis, Missouri, 63110, United States
The Foundation for Sickle Cell Disease
RECRUITING

Hollywood, Florida, 33023-6703, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43085, United States
Univ. of California, San Francisco Health Care
RECRUITING

Oakland, California, 94609, United States
University of California Irvine
NOT_YET_RECRUITING

Orange, California, 92868, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Illinois at Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Louisville Hospital
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States
Özel Acibadem Adana Hastanesi
NOT_YET_RECRUITING

Seyhan, 01130, Turkey (Türkiye)
Özel Acibadem Adana Hastanesi
RECRUITING

Seyhan/Adana, 01130, Turkey (Türkiye)