Promising sickle cell drug moves to kids: could cut painful episodes
NCT ID NCT03474965
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times
Summary
This study tested the safety and best dose of a drug called crizanlizumab in children aged 2 to 18 with sickle cell disease who have had painful crises. The drug aims to reduce these pain episodes by blocking cells from sticking to blood vessels. 117 children received the drug for up to 2 years, with or without their usual medicine hydroxyurea.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Childrens Healthcare of Atlanta
Atlanta, Georgia, 30342, United States
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Childrens Hosp Boston Dept of Hematology
Boston, Massachusetts, 02115, United States
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Childrens Hospital Of Philadelphia
Philadelphia, Pennsylvania, 19104-4399, United States
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Childrens Hospital at Montefiore
The Bronx, New York, 10467, United States
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Childrens National Hospital
Washington D.C., District of Columbia, 20010, United States
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Cook Childrens Medical Center
Fort Worth, Texas, 76104, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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East Carolina University
Greenville, North Carolina, 27834, United States
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Joe DiMaggio Childrens Hospital
Hollywood, Florida, 33021, United States
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Medical Uni of South Carolina
Charleston, South Carolina, 29425, United States
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Novartis Investigative Site
Brussels, 1000, Belgium
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Novartis Investigative Site
Laken, 1020, Belgium
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Novartis Investigative Site
Liège, 4000, Belgium
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Novartis Investigative Site
Salvador, Estado de Bahia, 41253-190, Brazil
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Novartis Investigative Site
Ribeirão Preto, São Paulo, 14048-900, Brazil
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Novartis Investigative Site
São Paulo, São Paulo, 01232-010, Brazil
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Novartis Investigative Site
Montreal, Quebec, H3T 1C5, Canada
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Novartis Investigative Site
Cali, Valle del Cauca Department, 760012, Colombia
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Novartis Investigative Site
Montería, 230004, Colombia
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Novartis Investigative Site
Paris, 75015, France
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Novartis Investigative Site
Heidelberg, 69120, Germany
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Novartis Investigative Site
Nagpur, Maharashtra, 440009, India
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Novartis Investigative Site
Padova, PD, 35128, Italy
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Novartis Investigative Site
Orbassano, TO, 10043, Italy
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Novartis Investigative Site
Beirut, 1107 2020, Lebanon
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Novartis Investigative Site
Tripoli, 1434, Lebanon
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Novartis Investigative Site
Muscat, 123, Oman
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Novartis Investigative Site
Palma de Mallorca, Balearic Islands, 07120, Spain
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Novartis Investigative Site
Barcelona, Catalonia, 08035, Spain
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Novartis Investigative Site
Madrid, 28009, Spain
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Novartis Investigative Site
Adana, 01330, Turkey (Türkiye)
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Novartis Investigative Site
Mersin, 33110, Turkey (Türkiye)
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Novartis Investigative Site
London, SE1 7EH, United Kingdom
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University Of Alabama
Birmingham, Alabama, 35233, United States
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University of Florida
Gainesville, Florida, 32610, United States
Conditions
Explore the condition pages connected to this study.